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- W4320921685 abstract "The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) represent two complex structures protecting the central nervous system (CNS) against potentially harmful agents and circulating immune cells. The immunosurveillance of the CNS is governed by immune cells that constantly patrol the BCSFB, whereas during neuroinflammatory disorders, both BBB and BCSFB undergo morphological and functional alterations, promoting leukocyte intravascular adhesion and transmigration from the blood circulation into the CNS. Multiple sclerosis (MS) is the prototype of neuroinflammatory disorders in which peripheral T helper (Th) lymphocytes, particularly Th1 and Th17 cells, infiltrate the CNS and contribute to demyelination and neurodegeneration. Th1 and Th17 cells are considered key players in the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis. They can actively interact with CNS borders by complex adhesion mechanisms and secretion of a variety of molecules contributing to barrier dysfunction. In this review, we describe the molecular basis involved in the interactions between Th cells and CNS barriers and discuss the emerging roles of dura mater and arachnoid layer as neuroimmune interfaces contributing to the development of CNS inflammatory diseases." @default.
- W4320921685 created "2023-02-16" @default.
- W4320921685 creator A5028728182 @default.
- W4320921685 creator A5058197372 @default.
- W4320921685 creator A5064990198 @default.
- W4320921685 creator A5079248337 @default.
- W4320921685 date "2023-02-15" @default.
- W4320921685 modified "2023-10-15" @default.
- W4320921685 title "The interplay between T helper cells and brain barriers in the pathogenesis of multiple sclerosis" @default.
- W4320921685 cites W105446306 @default.
- W4320921685 cites W114001912 @default.
- W4320921685 cites W1490272023 @default.
- W4320921685 cites W1514064771 @default.
- W4320921685 cites W1517869046 @default.
- W4320921685 cites W1528299210 @default.
- W4320921685 cites W1547957565 @default.
- W4320921685 cites W1577796071 @default.
- W4320921685 cites W1588685142 @default.
- W4320921685 cites W1594394126 @default.
- W4320921685 cites W1597008992 @default.
- W4320921685 cites W1600560134 @default.
- W4320921685 cites W1618146939 @default.
- W4320921685 cites W1789772972 @default.
- W4320921685 cites W1790006858 @default.
- W4320921685 cites W1791569952 @default.
- W4320921685 cites W1821663971 @default.
- W4320921685 cites W1867019379 @default.
- W4320921685 cites W1870974045 @default.
- W4320921685 cites W1890836614 @default.
- W4320921685 cites W1905950082 @default.
- W4320921685 cites W1920044084 @default.
- W4320921685 cites W1934778253 @default.
- W4320921685 cites W1941855945 @default.
- W4320921685 cites W1942368010 @default.
- W4320921685 cites W1942668068 @default.
- W4320921685 cites W1948291240 @default.
- W4320921685 cites W1950477528 @default.
- W4320921685 cites W1955617899 @default.
- W4320921685 cites W1960336193 @default.
- W4320921685 cites W1964134808 @default.
- W4320921685 cites W1965112519 @default.
- W4320921685 cites W1965307089 @default.
- W4320921685 cites W1967616873 @default.
- W4320921685 cites W1967948598 @default.
- W4320921685 cites W1970077849 @default.
- W4320921685 cites W1972752407 @default.
- W4320921685 cites W1973000903 @default.
- W4320921685 cites W1973867020 @default.
- W4320921685 cites W1974941387 @default.
- W4320921685 cites W1980386568 @default.
- W4320921685 cites W1982021670 @default.
- W4320921685 cites W1988372860 @default.
- W4320921685 cites W1989848313 @default.
- W4320921685 cites W1991361780 @default.
- W4320921685 cites W1991884672 @default.
- W4320921685 cites W1992904388 @default.
- W4320921685 cites W1993746949 @default.
- W4320921685 cites W1994995252 @default.
- W4320921685 cites W1995991167 @default.
- W4320921685 cites W1996266000 @default.
- W4320921685 cites W1997973706 @default.
- W4320921685 cites W1998000193 @default.
- W4320921685 cites W2001448765 @default.
- W4320921685 cites W2001535098 @default.
- W4320921685 cites W2002990292 @default.
- W4320921685 cites W2014628365 @default.
- W4320921685 cites W2015201031 @default.
- W4320921685 cites W2017436306 @default.
- W4320921685 cites W2017605183 @default.
- W4320921685 cites W2019926860 @default.
- W4320921685 cites W2020319641 @default.
- W4320921685 cites W2020769853 @default.
- W4320921685 cites W2026369420 @default.
- W4320921685 cites W2026520986 @default.
- W4320921685 cites W2028417725 @default.
- W4320921685 cites W2028935955 @default.
- W4320921685 cites W2034781062 @default.
- W4320921685 cites W2035809865 @default.
- W4320921685 cites W2037324465 @default.
- W4320921685 cites W2041264117 @default.
- W4320921685 cites W2045645323 @default.
- W4320921685 cites W2045717926 @default.
- W4320921685 cites W2050604953 @default.
- W4320921685 cites W2051663530 @default.
- W4320921685 cites W2054254705 @default.
- W4320921685 cites W2054624000 @default.
- W4320921685 cites W2057939648 @default.
- W4320921685 cites W2058465128 @default.
- W4320921685 cites W2061660439 @default.
- W4320921685 cites W2065186655 @default.
- W4320921685 cites W2068692326 @default.
- W4320921685 cites W2070498846 @default.
- W4320921685 cites W2070573684 @default.
- W4320921685 cites W2071205488 @default.
- W4320921685 cites W2071545791 @default.
- W4320921685 cites W2074466423 @default.
- W4320921685 cites W2083866874 @default.
- W4320921685 cites W2084388036 @default.
- W4320921685 cites W2084990572 @default.
- W4320921685 cites W2088156479 @default.