FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320922068> ?p ?o ?g. }

• W4320922068 endingPage "924" @default.
• W4320922068 startingPage "917" @default.
• W4320922068 abstract "Background Prior infection with Burkholderia cepacia complex (BCC) has been associated with poorer outcomes after lung transplantation, posing an important dilemma for cystic fibrosis (CF). Although current guidelines consider BCC infection to be a relative contraindication, some centers continue to offer lung transplantation to BCC-infected CF patients. Methods We conducted a retrospective cohort study which included all consecutive CF-LTR between 2000 and 2019 to compare the postoperative survival of BCC-infected CF lung transplant recipients (CF-LTR) to BCC-uninfected patients. We used a Kaplan-Meier analysis to compare survival of BCC-infected to BCC-uninfected CF-LTR and fitted a multivariable Cox model, adjusted for age, sex, BMI and year of transplantation as potential confounders. As an exploratory analysis, Kaplan-Meier curves were also stratified by the presence of BCC and urgency of transplantation. Results A total of 205 patients were included with a mean age of 30.5 years. Seventeen patients (8%) were infected with BCC prior to LT. Patients were infected with the following species: B. multivorans5, B. vietnamiensis3, combined B. multivorans and B. vietnamiensis3 and others4. None of the patients were infected with B. cenocepacia. Three patients were infected with B. gladioli. One-year survival was 91.7% (188/205) for the entire cohort, 82.4% (14/17) among BCC-infected CF-LTR, and 92.5% (173/188) among BCC uninfected CF-LTR (crude HR = 2.19; 95%CI 0.99-4.85; p = 0.05). In the multivariable model, presence of BCC was not significantly associated with worse survival (adjusted HR 1.89; 95%CI 0.85-4.24; p = 0.12). In the stratified analysis for both presence of BCC and urgency of transplantation, urgency of transplantation among BCC-infected CF-LTR appeared to be associated with poorer outcome (p = 0.003 across the 4 subgroups). Conclusion Our results suggest that non-cenocepacia BCC-infected CF-LTR have comparable survival rate to BCC-uninfected CF-LTR. Prior infection with Burkholderia cepacia complex (BCC) has been associated with poorer outcomes after lung transplantation, posing an important dilemma for cystic fibrosis (CF). Although current guidelines consider BCC infection to be a relative contraindication, some centers continue to offer lung transplantation to BCC-infected CF patients. We conducted a retrospective cohort study which included all consecutive CF-LTR between 2000 and 2019 to compare the postoperative survival of BCC-infected CF lung transplant recipients (CF-LTR) to BCC-uninfected patients. We used a Kaplan-Meier analysis to compare survival of BCC-infected to BCC-uninfected CF-LTR and fitted a multivariable Cox model, adjusted for age, sex, BMI and year of transplantation as potential confounders. As an exploratory analysis, Kaplan-Meier curves were also stratified by the presence of BCC and urgency of transplantation. A total of 205 patients were included with a mean age of 30.5 years. Seventeen patients (8%) were infected with BCC prior to LT. Patients were infected with the following species: B. multivorans5, B. vietnamiensis3, combined B. multivorans and B. vietnamiensis3 and others4. None of the patients were infected with B. cenocepacia. Three patients were infected with B. gladioli. One-year survival was 91.7% (188/205) for the entire cohort, 82.4% (14/17) among BCC-infected CF-LTR, and 92.5% (173/188) among BCC uninfected CF-LTR (crude HR = 2.19; 95%CI 0.99-4.85; p = 0.05). In the multivariable model, presence of BCC was not significantly associated with worse survival (adjusted HR 1.89; 95%CI 0.85-4.24; p = 0.12). In the stratified analysis for both presence of BCC and urgency of transplantation, urgency of transplantation among BCC-infected CF-LTR appeared to be associated with poorer outcome (p = 0.003 across the 4 subgroups). Our results suggest that non-cenocepacia BCC-infected CF-LTR have comparable survival rate to BCC-uninfected CF-LTR." @default.
• W4320922068 created "2023-02-16" @default.
• W4320922068 creator A5010873053 @default.
• W4320922068 creator A5029055216 @default.
• W4320922068 creator A5033430606 @default.
• W4320922068 creator A5053473599 @default.
• W4320922068 creator A5065275231 @default.
• W4320922068 creator A5068455382 @default.
• W4320922068 creator A5068924955 @default.
• W4320922068 creator A5071091208 @default.
• W4320922068 creator A5071100912 @default.
• W4320922068 date "2023-07-01" @default.
• W4320922068 modified "2023-09-26" @default.
• W4320922068 title "Post-transplant outcomes among cystic fibrosis patients undergoing lung transplantation colonized by Burkholderia: A single center cohort study" @default.
• W4320922068 cites W1924574913 @default.
• W4320922068 cites W2008937743 @default.
• W4320922068 cites W2028144518 @default.
• W4320922068 cites W2031945539 @default.
• W4320922068 cites W2051556779 @default.
• W4320922068 cites W2080975555 @default.
• W4320922068 cites W2081925747 @default.
• W4320922068 cites W2097905651 @default.
• W4320922068 cites W2102144745 @default.
• W4320922068 cites W2105642553 @default.
• W4320922068 cites W2111761921 @default.
• W4320922068 cites W2111914946 @default.
• W4320922068 cites W2118596099 @default.
• W4320922068 cites W2133019613 @default.
• W4320922068 cites W2135536325 @default.
• W4320922068 cites W2163626935 @default.
• W4320922068 cites W2275348113 @default.
• W4320922068 cites W2293328090 @default.
• W4320922068 cites W2324331905 @default.
• W4320922068 cites W2791532763 @default.
• W4320922068 cites W2884431546 @default.
• W4320922068 cites W2898174552 @default.
• W4320922068 cites W2922985458 @default.
• W4320922068 cites W3008701465 @default.
• W4320922068 cites W3043096789 @default.
• W4320922068 cites W3164155365 @default.
• W4320922068 cites W3183806681 @default.
• W4320922068 doi "https://doi.org/10.1016/j.healun.2023.02.001" @default.
• W4320922068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36894412" @default.
• W4320922068 hasPublicationYear "2023" @default.
• W4320922068 type Work @default.
• W4320922068 citedByCount "0" @default.
• W4320922068 crossrefType "journal-article" @default.
• W4320922068 hasAuthorship W4320922068A5010873053 @default.
• W4320922068 hasAuthorship W4320922068A5029055216 @default.
• W4320922068 hasAuthorship W4320922068A5033430606 @default.
• W4320922068 hasAuthorship W4320922068A5053473599 @default.
• W4320922068 hasAuthorship W4320922068A5065275231 @default.
• W4320922068 hasAuthorship W4320922068A5068455382 @default.
• W4320922068 hasAuthorship W4320922068A5068924955 @default.
• W4320922068 hasAuthorship W4320922068A5071091208 @default.
• W4320922068 hasAuthorship W4320922068A5071100912 @default.
• W4320922068 hasConcept C10515644 @default.
• W4320922068 hasConcept C126322002 @default.
• W4320922068 hasConcept C141071460 @default.
• W4320922068 hasConcept C142724271 @default.
• W4320922068 hasConcept C167135981 @default.
• W4320922068 hasConcept C204787440 @default.
• W4320922068 hasConcept C207103383 @default.
• W4320922068 hasConcept C2776494729 @default.
• W4320922068 hasConcept C2776938444 @default.
• W4320922068 hasConcept C2777756538 @default.
• W4320922068 hasConcept C2777979451 @default.
• W4320922068 hasConcept C2780073493 @default.
• W4320922068 hasConcept C2780855054 @default.
• W4320922068 hasConcept C2781448352 @default.
• W4320922068 hasConcept C2911091166 @default.
• W4320922068 hasConcept C44249647 @default.
• W4320922068 hasConcept C50382708 @default.
• W4320922068 hasConcept C523546767 @default.
• W4320922068 hasConcept C54355233 @default.
• W4320922068 hasConcept C71924100 @default.
• W4320922068 hasConcept C72563966 @default.
• W4320922068 hasConcept C86803240 @default.
• W4320922068 hasConcept C90924648 @default.
• W4320922068 hasConceptScore W4320922068C10515644 @default.
• W4320922068 hasConceptScore W4320922068C126322002 @default.
• W4320922068 hasConceptScore W4320922068C141071460 @default.
• W4320922068 hasConceptScore W4320922068C142724271 @default.
• W4320922068 hasConceptScore W4320922068C167135981 @default.
• W4320922068 hasConceptScore W4320922068C204787440 @default.
• W4320922068 hasConceptScore W4320922068C207103383 @default.
• W4320922068 hasConceptScore W4320922068C2776494729 @default.
• W4320922068 hasConceptScore W4320922068C2776938444 @default.
• W4320922068 hasConceptScore W4320922068C2777756538 @default.
• W4320922068 hasConceptScore W4320922068C2777979451 @default.
• W4320922068 hasConceptScore W4320922068C2780073493 @default.
• W4320922068 hasConceptScore W4320922068C2780855054 @default.
• W4320922068 hasConceptScore W4320922068C2781448352 @default.
• W4320922068 hasConceptScore W4320922068C2911091166 @default.
• W4320922068 hasConceptScore W4320922068C44249647 @default.
• W4320922068 hasConceptScore W4320922068C50382708 @default.
• W4320922068 hasConceptScore W4320922068C523546767 @default.
• W4320922068 hasConceptScore W4320922068C54355233 @default.

• next