Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320922421> ?p ?o ?g. }
- W4320922421 abstract "Abstract Neuroinflammation is a hallmark of ischemic stroke, which is a leading cause of death and long-term disability. Understanding the exact cellular signaling pathways that initiate and propagate neuroinflammation after stroke will be critical for developing immunomodulatory stroke therapies. In particular, the precise mechanisms of inflammatory signaling in the clinically relevant hyperacute period, hours after stroke, have not been elucidated. We used the RiboTag technique to obtain astrocyte and microglia-derived mRNA transcripts in a hyperacute (4 hours) and acute (3 days) period after stroke, as these two cell types are key modulators of acute neuroinflammation. Microglia initiated a rapid response to stroke at 4 hours by adopting an inflammatory profile associated with the recruitment of immune cells. The hyperacute astrocyte profile was marked by stress response genes and transcription factors, such as Fos and Jun , involved in pro-inflammatory pathways such as TNF-α. By 3 days, microglia shift to a proliferative state and astrocytes strengthen their inflammatory response. The astrocyte pro-inflammatory response at 3 days is partially driven by the upregulation of the transcription factors C/EBPβ, Spi1 , and Rel , which comprise 25% of upregulated transcription factor-target interactions. Surprisingly, few sex differences across all groups were observed. Expression and log 2 fold data for all sequenced genes are available on a user-friendly website for researchers to examine gene changes and generate hypotheses for stroke targets. Taken together our data comprehensively describe the astrocyte and microglia-specific translatome response in the hyperacute and acute period after stroke and identify pathways critical for initiating neuroinflammation." @default.
- W4320922421 created "2023-02-16" @default.
- W4320922421 creator A5016744654 @default.
- W4320922421 creator A5034662634 @default.
- W4320922421 creator A5035363909 @default.
- W4320922421 creator A5035389816 @default.
- W4320922421 creator A5037429056 @default.
- W4320922421 creator A5043716101 @default.
- W4320922421 creator A5046209279 @default.
- W4320922421 creator A5056175375 @default.
- W4320922421 date "2023-02-14" @default.
- W4320922421 modified "2023-10-01" @default.
- W4320922421 title "Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke" @default.
- W4320922421 cites W1494319831 @default.
- W4320922421 cites W1607342455 @default.
- W4320922421 cites W179818011 @default.
- W4320922421 cites W1931831452 @default.
- W4320922421 cites W1972534236 @default.
- W4320922421 cites W1975572742 @default.
- W4320922421 cites W1976775990 @default.
- W4320922421 cites W1983835442 @default.
- W4320922421 cites W1989211089 @default.
- W4320922421 cites W1999574084 @default.
- W4320922421 cites W2018439988 @default.
- W4320922421 cites W2020552736 @default.
- W4320922421 cites W2028314455 @default.
- W4320922421 cites W2036897871 @default.
- W4320922421 cites W2039167252 @default.
- W4320922421 cites W2040785390 @default.
- W4320922421 cites W2045835005 @default.
- W4320922421 cites W2078253512 @default.
- W4320922421 cites W2079201863 @default.
- W4320922421 cites W2083489746 @default.
- W4320922421 cites W2084566588 @default.
- W4320922421 cites W2094115917 @default.
- W4320922421 cites W2096500024 @default.
- W4320922421 cites W2107773056 @default.
- W4320922421 cites W2108181817 @default.
- W4320922421 cites W2118200665 @default.
- W4320922421 cites W2123106337 @default.
- W4320922421 cites W2124836944 @default.
- W4320922421 cites W2130410032 @default.
- W4320922421 cites W2133465414 @default.
- W4320922421 cites W2135376726 @default.
- W4320922421 cites W2135768865 @default.
- W4320922421 cites W2140118974 @default.
- W4320922421 cites W2144806891 @default.
- W4320922421 cites W2145431360 @default.
- W4320922421 cites W2146152985 @default.
- W4320922421 cites W2155477484 @default.
- W4320922421 cites W2158217645 @default.
- W4320922421 cites W2160431149 @default.
- W4320922421 cites W2161057248 @default.
- W4320922421 cites W2163410184 @default.
- W4320922421 cites W2169456326 @default.
- W4320922421 cites W2171979248 @default.
- W4320922421 cites W2179438025 @default.
- W4320922421 cites W2180744905 @default.
- W4320922421 cites W2215096491 @default.
- W4320922421 cites W2242638094 @default.
- W4320922421 cites W2280077905 @default.
- W4320922421 cites W2335534790 @default.
- W4320922421 cites W2345329114 @default.
- W4320922421 cites W2462174583 @default.
- W4320922421 cites W2537241347 @default.
- W4320922421 cites W2537351581 @default.
- W4320922421 cites W2572710398 @default.
- W4320922421 cites W2606737383 @default.
- W4320922421 cites W2615586845 @default.
- W4320922421 cites W2622807556 @default.
- W4320922421 cites W2754890392 @default.
- W4320922421 cites W2763928642 @default.
- W4320922421 cites W2767973764 @default.
- W4320922421 cites W2775595726 @default.
- W4320922421 cites W2782274120 @default.
- W4320922421 cites W2782454362 @default.
- W4320922421 cites W2790139801 @default.
- W4320922421 cites W2795435173 @default.
- W4320922421 cites W2804756252 @default.
- W4320922421 cites W2808882111 @default.
- W4320922421 cites W2838315183 @default.
- W4320922421 cites W2885498250 @default.
- W4320922421 cites W2889283495 @default.
- W4320922421 cites W2890250594 @default.
- W4320922421 cites W2896883303 @default.
- W4320922421 cites W2901838561 @default.
- W4320922421 cites W2902222116 @default.
- W4320922421 cites W2905732856 @default.
- W4320922421 cites W2913221496 @default.
- W4320922421 cites W2934339908 @default.
- W4320922421 cites W2950221693 @default.
- W4320922421 cites W2951344798 @default.
- W4320922421 cites W2953564389 @default.
- W4320922421 cites W2957574262 @default.
- W4320922421 cites W2968346446 @default.
- W4320922421 cites W2977622316 @default.
- W4320922421 cites W3016799112 @default.
- W4320922421 cites W3022448963 @default.
- W4320922421 cites W3038072693 @default.
- W4320922421 cites W3081839279 @default.