Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321002214> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4321002214 abstract "The bacterial endophytes isolated from the halophyte Salicornia brachiata were explored for the antimicrobial potential to discover novel microbial inhibitors that combat multidrug resistance. Upon investigation, ethyl acetate extract of the endophyte Bacillus subtilis NPROOT3 displayed significant potency against Mycobacterium smegmatis MTCC6 as well as Mycobacterium tuberculosis H37Rv strain. Further investigation of ethyl acetate crude extract by repeated chromatographic separations followed by characterization using UV, HR-ESI-MS, MALDI-MS, MALDI-MS/MS, CD, and NMR spectroscopy yielded a series of five known siderophores, namely, SVK21 (1), bacillibactin C (2), bacillibactin B (3), tribenglthin A (4), and bacillibactin (5). A total of two out of five compounds, 4 (MIC 38.66 μM) and 5 (MIC 22.15 μM) exhibited significant inhibition against the strain M. smegmatis MTCC6 comparable with positive control rifampicin (MIC 12.15 μM). None of these five bacillibactin molecules are previously reported to exhibit bioactivity against Mycobacterium sp. Herein for the first time, all the compounds were screened for their antibacterial activities against a panel of bacterial pathogens of humans. Furthermore, the probable mechanism of action of bacillibactin compounds for their antimycobacterial activity is also discussed. The findings of this study open up a new chemotype for inhibition of the Mycobacterium sp. and other multidrug-resistant pathogens." @default.
- W4321002214 created "2023-02-17" @default.
- W4321002214 creator A5006646049 @default.
- W4321002214 creator A5038844007 @default.
- W4321002214 creator A5058360880 @default.
- W4321002214 creator A5060914412 @default.
- W4321002214 creator A5061440342 @default.
- W4321002214 creator A5065297081 @default.
- W4321002214 date "2023-02-16" @default.
- W4321002214 modified "2023-10-17" @default.
- W4321002214 title "Bacillibactin class siderophores produced by the endophyte Bacillus subtilis NPROOT3 as antimycobacterial agents." @default.
- W4321002214 doi "https://doi.org/10.1093/lambio/ovac026" @default.
- W4321002214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36794884" @default.
- W4321002214 hasPublicationYear "2023" @default.
- W4321002214 type Work @default.
- W4321002214 citedByCount "3" @default.
- W4321002214 countsByYear W43210022142023 @default.
- W4321002214 crossrefType "journal-article" @default.
- W4321002214 hasAuthorship W4321002214A5006646049 @default.
- W4321002214 hasAuthorship W4321002214A5038844007 @default.
- W4321002214 hasAuthorship W4321002214A5058360880 @default.
- W4321002214 hasAuthorship W4321002214A5060914412 @default.
- W4321002214 hasAuthorship W4321002214A5061440342 @default.
- W4321002214 hasAuthorship W4321002214A5065297081 @default.
- W4321002214 hasConcept C108319773 @default.
- W4321002214 hasConcept C142724271 @default.
- W4321002214 hasConcept C176947019 @default.
- W4321002214 hasConcept C2777204207 @default.
- W4321002214 hasConcept C2777272437 @default.
- W4321002214 hasConcept C2777525088 @default.
- W4321002214 hasConcept C2777975735 @default.
- W4321002214 hasConcept C2779685592 @default.
- W4321002214 hasConcept C2779858419 @default.
- W4321002214 hasConcept C2780374374 @default.
- W4321002214 hasConcept C2781069245 @default.
- W4321002214 hasConcept C4937899 @default.
- W4321002214 hasConcept C523546767 @default.
- W4321002214 hasConcept C54355233 @default.
- W4321002214 hasConcept C55493867 @default.
- W4321002214 hasConcept C59822182 @default.
- W4321002214 hasConcept C71924100 @default.
- W4321002214 hasConcept C86803240 @default.
- W4321002214 hasConcept C89423630 @default.
- W4321002214 hasConceptScore W4321002214C108319773 @default.
- W4321002214 hasConceptScore W4321002214C142724271 @default.
- W4321002214 hasConceptScore W4321002214C176947019 @default.
- W4321002214 hasConceptScore W4321002214C2777204207 @default.
- W4321002214 hasConceptScore W4321002214C2777272437 @default.
- W4321002214 hasConceptScore W4321002214C2777525088 @default.
- W4321002214 hasConceptScore W4321002214C2777975735 @default.
- W4321002214 hasConceptScore W4321002214C2779685592 @default.
- W4321002214 hasConceptScore W4321002214C2779858419 @default.
- W4321002214 hasConceptScore W4321002214C2780374374 @default.
- W4321002214 hasConceptScore W4321002214C2781069245 @default.
- W4321002214 hasConceptScore W4321002214C4937899 @default.
- W4321002214 hasConceptScore W4321002214C523546767 @default.
- W4321002214 hasConceptScore W4321002214C54355233 @default.
- W4321002214 hasConceptScore W4321002214C55493867 @default.
- W4321002214 hasConceptScore W4321002214C59822182 @default.
- W4321002214 hasConceptScore W4321002214C71924100 @default.
- W4321002214 hasConceptScore W4321002214C86803240 @default.
- W4321002214 hasConceptScore W4321002214C89423630 @default.
- W4321002214 hasIssue "2" @default.
- W4321002214 hasLocation W43210022141 @default.
- W4321002214 hasOpenAccess W4321002214 @default.
- W4321002214 hasPrimaryLocation W43210022141 @default.
- W4321002214 hasRelatedWork W1997276814 @default.
- W4321002214 hasRelatedWork W2059187763 @default.
- W4321002214 hasRelatedWork W2065188890 @default.
- W4321002214 hasRelatedWork W2081858232 @default.
- W4321002214 hasRelatedWork W2120266933 @default.
- W4321002214 hasRelatedWork W2187240800 @default.
- W4321002214 hasRelatedWork W2414560525 @default.
- W4321002214 hasRelatedWork W2516302425 @default.
- W4321002214 hasRelatedWork W2949288546 @default.
- W4321002214 hasRelatedWork W4321002214 @default.
- W4321002214 hasVolume "76" @default.
- W4321002214 isParatext "false" @default.
- W4321002214 isRetracted "false" @default.
- W4321002214 workType "article" @default.