Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321002351> ?p ?o ?g. }
- W4321002351 endingPage "609" @default.
- W4321002351 startingPage "599" @default.
- W4321002351 abstract "Thrombosis is the second leading cause of mortality in cancer patients. This study aimed to investigate the association between cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) and thrombosis.A retrospective pharmacovigilance analysis based on real-world data combined with a systematic review was used to explore the thrombotic risk profiles of CDK4/6i. The study has been registered with Prospero (CRD42021284218).In the pharmacovigilance analysis, CDK4/6i showed a higher rate of reported venous thromboembolism (VTE) (ROR = 2.78, 95% CI = 2.64-2.92), with the highest signal for trilaciclib (ROR = 27.55, 95% CI = 13.43-56.52) but only 9 cases, followed by abemaciclib (ROR = 3.73, 95% CI = 3.19-4.37). For arterial thromboembolism (ATE), only ribociclib increased the reporting rate (ROR = 2.14, 95% CI = 1.91-2.41). In the meta-analysis, palbociclib, abemaciclib, and trilaciclib all increased the risk of VTE (OR = 2.23, 3.17, and 3.90). In the subgroup analysis, only abemaciclib increased the risk of ATE (OR = 2.11, 95% CI = 1.12-3.99) .CDK4/6i had different profiles of thromboembolism. Palbociclib, abemaciclib, or trilaciclib increased the risk of VTE. Ribociclib and abemaciclib showed a weak association with the risk of ATE." @default.
- W4321002351 created "2023-02-17" @default.
- W4321002351 creator A5008567434 @default.
- W4321002351 creator A5010869663 @default.
- W4321002351 creator A5013322966 @default.
- W4321002351 creator A5021966023 @default.
- W4321002351 creator A5046853045 @default.
- W4321002351 creator A5050268277 @default.
- W4321002351 creator A5058538766 @default.
- W4321002351 creator A5068628266 @default.
- W4321002351 creator A5079638418 @default.
- W4321002351 creator A5079817705 @default.
- W4321002351 creator A5089384406 @default.
- W4321002351 date "2023-02-23" @default.
- W4321002351 modified "2023-10-18" @default.
- W4321002351 title "Thromboembolism profiles associated with cyclin-dependent kinase 4/6 inhibitors: a real-world pharmacovigilance study and a systematic review" @default.
- W4321002351 cites W1972891674 @default.
- W4321002351 cites W1996239270 @default.
- W4321002351 cites W2017316291 @default.
- W4321002351 cites W2074289946 @default.
- W4321002351 cites W2125435699 @default.
- W4321002351 cites W2144790402 @default.
- W4321002351 cites W2380343767 @default.
- W4321002351 cites W2474699717 @default.
- W4321002351 cites W2552099557 @default.
- W4321002351 cites W2567362164 @default.
- W4321002351 cites W2611183622 @default.
- W4321002351 cites W2620993107 @default.
- W4321002351 cites W2763875663 @default.
- W4321002351 cites W2804105316 @default.
- W4321002351 cites W2805575723 @default.
- W4321002351 cites W2897723485 @default.
- W4321002351 cites W2970740914 @default.
- W4321002351 cites W2971507604 @default.
- W4321002351 cites W2977211443 @default.
- W4321002351 cites W2994903788 @default.
- W4321002351 cites W3005929774 @default.
- W4321002351 cites W3029215507 @default.
- W4321002351 cites W3035904770 @default.
- W4321002351 cites W3041269916 @default.
- W4321002351 cites W3092090680 @default.
- W4321002351 cites W3093770108 @default.
- W4321002351 cites W3095826473 @default.
- W4321002351 cites W3097340813 @default.
- W4321002351 cites W3097489112 @default.
- W4321002351 cites W3115102504 @default.
- W4321002351 cites W3119638819 @default.
- W4321002351 cites W3120241209 @default.
- W4321002351 cites W3126641566 @default.
- W4321002351 cites W3128459239 @default.
- W4321002351 cites W3138893930 @default.
- W4321002351 cites W3141415256 @default.
- W4321002351 cites W3203817426 @default.
- W4321002351 cites W3217145210 @default.
- W4321002351 cites W4200357248 @default.
- W4321002351 cites W4206349107 @default.
- W4321002351 cites W4226215812 @default.
- W4321002351 cites W4253278951 @default.
- W4321002351 cites W4283688352 @default.
- W4321002351 cites W4294215472 @default.
- W4321002351 cites W4296904106 @default.
- W4321002351 cites W4323284481 @default.
- W4321002351 doi "https://doi.org/10.1080/14740338.2023.2181338" @default.
- W4321002351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36794339" @default.
- W4321002351 hasPublicationYear "2023" @default.
- W4321002351 type Work @default.
- W4321002351 citedByCount "0" @default.
- W4321002351 crossrefType "journal-article" @default.
- W4321002351 hasAuthorship W4321002351A5008567434 @default.
- W4321002351 hasAuthorship W4321002351A5010869663 @default.
- W4321002351 hasAuthorship W4321002351A5013322966 @default.
- W4321002351 hasAuthorship W4321002351A5021966023 @default.
- W4321002351 hasAuthorship W4321002351A5046853045 @default.
- W4321002351 hasAuthorship W4321002351A5050268277 @default.
- W4321002351 hasAuthorship W4321002351A5058538766 @default.
- W4321002351 hasAuthorship W4321002351A5068628266 @default.
- W4321002351 hasAuthorship W4321002351A5079638418 @default.
- W4321002351 hasAuthorship W4321002351A5079817705 @default.
- W4321002351 hasAuthorship W4321002351A5089384406 @default.
- W4321002351 hasConcept C121608353 @default.
- W4321002351 hasConcept C126322002 @default.
- W4321002351 hasConcept C143998085 @default.
- W4321002351 hasConcept C197934379 @default.
- W4321002351 hasConcept C2775930923 @default.
- W4321002351 hasConcept C2779744173 @default.
- W4321002351 hasConcept C2780868729 @default.
- W4321002351 hasConcept C2991741193 @default.
- W4321002351 hasConcept C530470458 @default.
- W4321002351 hasConcept C57658597 @default.
- W4321002351 hasConcept C71924100 @default.
- W4321002351 hasConceptScore W4321002351C121608353 @default.
- W4321002351 hasConceptScore W4321002351C126322002 @default.
- W4321002351 hasConceptScore W4321002351C143998085 @default.
- W4321002351 hasConceptScore W4321002351C197934379 @default.
- W4321002351 hasConceptScore W4321002351C2775930923 @default.
- W4321002351 hasConceptScore W4321002351C2779744173 @default.
- W4321002351 hasConceptScore W4321002351C2780868729 @default.
- W4321002351 hasConceptScore W4321002351C2991741193 @default.