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- W4321004024 abstract "Natural products (NPs) have long been associated with human production and play a key role in the survival of species. Significant variations in NP content may severely affect the return on investment of NP-based industries and render ecological systems vulnerable. Thus, it is crucial to construct a platform that relates variations in NP content to their corresponding mechanisms. In this study, a publicly accessible online platform, NPcVar (http://npcvar.idrblab.net/), was developed, which systematically described the variations of NP contents and their corresponding mechanisms. The platform comprises 2201 NPs and 694 biological resources, including plants, bacteria, and fungi, curated using 126 diverse factors with 26,425 records. Each record contains information about the species, NP, and factors involved, as well as NP content data, parts of the plant that produce NPs, the location of the experiment, and reference information. All factors were manually curated and categorized into 42 classes which belong to four mechanisms (molecular regulation, species factor, environmental condition, and combined factor). Additionally, the cross-links of species and NP to well-established databases and the visualization of NP content under various experimental conditions were provided. In conclusion, NPcVar is a valuable resource for understanding the relationship between species, factors, and NP contents and is anticipated to serve as a promising tool for improving the yield of high-value NPs and facilitating the development of new therapeutics." @default.
- W4321004024 created "2023-02-17" @default.
- W4321004024 creator A5002188808 @default.
- W4321004024 creator A5004326219 @default.
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- W4321004024 creator A5086001755 @default.
- W4321004024 date "2023-02-16" @default.
- W4321004024 modified "2023-10-14" @default.
- W4321004024 title "Systematic Description of the Content Variation of Natural Products (NPs): To Prompt the Yield of High-Value NPs and the Discovery of New Therapeutics" @default.
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