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• W4321004080 startingPage "e0281957" @default.
• W4321004080 abstract "Parkinson disease is a chronic progressive neurodegenerative disorder with a prevalence that increases with age. The glycolytic end-product pyruvate, has antioxidant and neuroprotective feature. Here, we investigated the effects of ethyl pyruvate (EP), a pyruvic acid derivative, on 6-hydroxydopamine-induced SH-SY5Y cell apoptosis. Ethyl pyruvate decreased protein levels of cleaved caspase-3, phosphorylated endoplasmic reticulum kinase (pERK), and extracellular signal-regulated kinase (ERK), suggesting that EP reduces apoptosis via the ERK signaling pathway. Ethyl pyruvate also decreased oxygen species (ROS) and neuromelanin contents, suggesting that it suppresses ROS-mediated neuromelanin synthesis. Furthermore, increased protein levels of Beclin-1 and LC-II, and LC-II:LC-I ratios indicated that EP upregulates autophagy." @default.
• W4321004080 created "2023-02-17" @default.
• W4321004080 creator A5034802768 @default.
• W4321004080 creator A5045809219 @default.
• W4321004080 date "2023-02-16" @default.
• W4321004080 modified "2023-09-30" @default.
• W4321004080 title "Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy" @default.
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• W4321004080 doi "https://doi.org/10.1371/journal.pone.0281957" @default.
• W4321004080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36795720" @default.
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