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- W4321004562 abstract "Peptide drugs have been successfully used for the treatment of various diseases. However, it is still challenging to develop therapeutic peptides working on intracellular targets due to their poor membrane permeability. Here, we proposed a type of dual-responsive bioconjugates bearing a heterobifunctional adaptor containing both aldehyde and catechol moieties for efficient cytosolic peptide delivery. Hydrazine-terminated cargo peptides were tagged to a boronated dendrimer with the help of the adaptor via dynamic acylhydrazone and catechol‑boronate linkages. The bioconjugates efficiently delivered peptides with distinct physicochemical properties into various cells, and could release the cargo peptides triggered by intracellular reactive oxygen species and endolysosomal acidity, restoring the biofunctions of delivered peptides. In addition, the designed complexes efficiently delivered a pro-apoptotic peptide into osteosarcoma cancer cells and successfully inhibited the tumor growth both in vitro and in vivo. This study provides a universal and efficient platform for cytosolic therapeutic peptide delivery to intracellular targets for treating various diseases." @default.
- W4321004562 created "2023-02-17" @default.
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- W4321004562 date "2023-03-01" @default.
- W4321004562 modified "2023-09-30" @default.
- W4321004562 title "Dual-responsive bioconjugates bearing a bifunctional adaptor for robust cytosolic peptide delivery" @default.
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- W4321004562 doi "https://doi.org/10.1016/j.jconrel.2023.02.014" @default.
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