Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321004782> ?p ?o ?g. }
- W4321004782 endingPage "503" @default.
- W4321004782 startingPage "493" @default.
- W4321004782 abstract "Cardiovascular diseases (CVD) are the leading cause of death worldwide and display complex phenotypic heterogeneity caused by many convergent processes, including interactions between genetic variation and environmental factors. Despite the identification of a large number of associated genes and genetic loci, the precise mechanisms by which these genes systematically influence the phenotypic heterogeneity of CVD are not well understood. In addition to DNA sequence, understanding the molecular mechanisms of CVD requires data from other omics levels, including the epigenome, the transcriptome, the proteome, as well as the metabolome. Recent advances in multiomics technologies have opened new precision medicine opportunities beyond genomics that can guide precise diagnosis and personalized treatment. At the same time, network medicine has emerged as an interdisciplinary field that integrates systems biology and network science to focus on the interactions among biological components in health and disease, providing an unbiased framework through which to integrate systematically these multiomics data. In this review, we briefly present such multiomics technologies, including bulk omics and single-cell omics technologies, and discuss how they can contribute to precision medicine. We then highlight network medicine-based integration of multiomics data for precision medicine and therapeutics in CVD. We also include a discussion of current challenges, potential limitations, and future directions in the study of CVD using multiomics network medicine approaches." @default.
- W4321004782 created "2023-02-17" @default.
- W4321004782 creator A5028396638 @default.
- W4321004782 creator A5036627838 @default.
- W4321004782 creator A5045540814 @default.
- W4321004782 date "2023-04-01" @default.
- W4321004782 modified "2023-09-27" @default.
- W4321004782 title "Multiomics Network Medicine Approaches to Precision Medicine and Therapeutics in Cardiovascular Diseases" @default.
- W4321004782 cites W1925096990 @default.
- W4321004782 cites W1981409633 @default.
- W4321004782 cites W1981509058 @default.
- W4321004782 cites W1987219048 @default.
- W4321004782 cites W2033836319 @default.
- W4321004782 cites W2042562951 @default.
- W4321004782 cites W2062533676 @default.
- W4321004782 cites W2070339716 @default.
- W4321004782 cites W2072302002 @default.
- W4321004782 cites W2077947016 @default.
- W4321004782 cites W2091576663 @default.
- W4321004782 cites W2151824797 @default.
- W4321004782 cites W2156589853 @default.
- W4321004782 cites W2238851414 @default.
- W4321004782 cites W2295182096 @default.
- W4321004782 cites W2295388714 @default.
- W4321004782 cites W2337969762 @default.
- W4321004782 cites W2341087328 @default.
- W4321004782 cites W2469450953 @default.
- W4321004782 cites W2512216892 @default.
- W4321004782 cites W2611138580 @default.
- W4321004782 cites W2775393828 @default.
- W4321004782 cites W2800216577 @default.
- W4321004782 cites W2883061610 @default.
- W4321004782 cites W2921554869 @default.
- W4321004782 cites W2975264981 @default.
- W4321004782 cites W2979167769 @default.
- W4321004782 cites W2980865512 @default.
- W4321004782 cites W2982552115 @default.
- W4321004782 cites W2997289492 @default.
- W4321004782 cites W2999208679 @default.
- W4321004782 cites W3013731060 @default.
- W4321004782 cites W3022420910 @default.
- W4321004782 cites W3045934808 @default.
- W4321004782 cites W3083820674 @default.
- W4321004782 cites W3088401235 @default.
- W4321004782 cites W3107156000 @default.
- W4321004782 cites W3108451992 @default.
- W4321004782 cites W3113178943 @default.
- W4321004782 cites W3115495889 @default.
- W4321004782 cites W3119250355 @default.
- W4321004782 cites W3127451872 @default.
- W4321004782 cites W3129003444 @default.
- W4321004782 cites W3133674722 @default.
- W4321004782 cites W3138200026 @default.
- W4321004782 cites W3150238428 @default.
- W4321004782 cites W3162949128 @default.
- W4321004782 cites W3163409627 @default.
- W4321004782 cites W3163849157 @default.
- W4321004782 cites W3164307931 @default.
- W4321004782 cites W3165414213 @default.
- W4321004782 cites W3184729641 @default.
- W4321004782 cites W3189144368 @default.
- W4321004782 cites W3202949860 @default.
- W4321004782 cites W3217284213 @default.
- W4321004782 cites W4200040059 @default.
- W4321004782 cites W4200416341 @default.
- W4321004782 cites W4205877786 @default.
- W4321004782 cites W4206956476 @default.
- W4321004782 cites W4210297497 @default.
- W4321004782 cites W4211214238 @default.
- W4321004782 cites W4213347069 @default.
- W4321004782 cites W4214546240 @default.
- W4321004782 cites W4225278475 @default.
- W4321004782 cites W4225695255 @default.
- W4321004782 cites W4226027293 @default.
- W4321004782 cites W4226152036 @default.
- W4321004782 cites W4226243684 @default.
- W4321004782 cites W4229335505 @default.
- W4321004782 cites W4248974836 @default.
- W4321004782 cites W4280598306 @default.
- W4321004782 cites W4282830382 @default.
- W4321004782 cites W4282939468 @default.
- W4321004782 cites W4283257569 @default.
- W4321004782 cites W4283261002 @default.
- W4321004782 cites W4283390936 @default.
- W4321004782 cites W4285500649 @default.
- W4321004782 cites W4285719527 @default.
- W4321004782 cites W4285728858 @default.
- W4321004782 cites W4289793679 @default.
- W4321004782 cites W4290989128 @default.
- W4321004782 cites W4301595188 @default.
- W4321004782 cites W4307658070 @default.
- W4321004782 cites W4310766578 @default.
- W4321004782 cites W74597864 @default.
- W4321004782 doi "https://doi.org/10.1161/atvbaha.122.318731" @default.
- W4321004782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36794589" @default.
- W4321004782 hasPublicationYear "2023" @default.
- W4321004782 type Work @default.
- W4321004782 citedByCount "4" @default.