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• W4321010080 abstract "Abstract In recent years, the prevalence of hand, foot, and mouth disease (HFMD)caused by enteroviruses other than enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16) has gradually increased. The throat swab specimens of 2701 HFMD cases were tested, the VP1 regions of CVA10 RNA were amplified using RT-PCR, and phylogenetic analysis of CVA10 was performed. Children aged 1–5 years accounted for the majority (81.65%) and boys was more than girls. The positivity rates of EV-A71, CVA16, and other EVs were 15.22% (219/1439), 28.77% (414/1439), and 56.01% (806/1439), respectively. CVA10 is one of the important viruses of other EVs. A total of 52 CVA10 strains were used for phylogenetic analysis based on the VP1 region, 31 were from this study, and 21 were downloaded from GenBank. All CVA10 sequences could be assigned to seven genotypes (A, B, C, D, E, F, and G), and genotype C was further divided into C1 and C2 subtypes, only one belonged to subtype C1 and the remaining 30 belonged toC2 in this study. This study emphasized the importance of strengthening the surveillance of the HFMD in order to understand the mechanisms of pathogen variation and evolution, so as to provide a scientific basis for HFMD prevention, control, and vaccine development." @default.
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• W4321010080 date "2023-02-17" @default.
• W4321010080 modified "2023-09-27" @default.
• W4321010080 title "Epidemiology of hand, foot, and mouth disease and genetic characteristics of Coxsackievirus A10 in Taiyuan City, Shanxi Province from 2016–2020" @default.
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• W4321010080 doi "https://doi.org/10.21203/rs.3.rs-1982880/v4" @default.
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