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• W4321018372 startingPage "293" @default.
• W4321018372 abstract "A detectable and rising PSA following radical prostatectomy is indicative of recurrent prostate cancer. Salvage radiotherapy (SRT) with/without androgen deprivation therapy represents the main treatment option for these patients and has been historically associated with a biochemical control rate of ~70%. To determine the optimal timing, diagnostic workup, radiotherapy dosefractionation, treatment volume, and use of systemic therapy, several informative studies have been conducted in the last decade.This review examines the recent evidence to guide radiotherapy decision making in the SRT setting. Key topics include adjuvant vs salvage RT, utilization of molecular imaging and genomic classifiers, length of androgen deprivation therapy, inclusion of elective pelvic volume, and emerging role for hypofractionation.Recently reported trials, conducted in an era prior to the routine use of molecular imaging and genomic classifiers, have been pivotal in establishing the current standard of care for SRT in prostate cancer. However, decisions about radiation treatment and systemic therapy may be tailored based on available prognostic and predictive biomarkers. Data from contemporary clinical trials are awaited to define and establish individualized, biomarker-driven approaches for SRT." @default.
• W4321018372 created "2023-02-17" @default.
• W4321018372 creator A5007971562 @default.
• W4321018372 creator A5013897212 @default.
• W4321018372 creator A5013986462 @default.
• W4321018372 creator A5022511452 @default.
• W4321018372 creator A5046636508 @default.
• W4321018372 creator A5065756866 @default.
• W4321018372 date "2023-02-27" @default.
• W4321018372 modified "2023-09-29" @default.
• W4321018372 title "Utilizing clinical, pathological and radiological information to guide postoperative radiotherapy in prostate cancer" @default.
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