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• W4321018487 abstract "Summary Macrophages play key roles in regulating and maintaining tissue and whole-body metabolism in both normal and disease states. While the cell-cell signaling pathway that underlie these functions are becoming clear, less is known about how alterations in macrophage metabolism influence their roles as regulators of systemic physiology. Here we investigate this by examining Drosophila macrophage-like cells called hemocytes. We used knockdown of TFAM, a mitochondrial genome transcription factor, to reduce mitochondrial OxPhos activity specifically in larval hemocytes. We find that this reduction in hemocyte OxPhos leads to a decrease in larval growth and body size. These effects are associated with a suppression of systemic insulin, the main endocrine stimulator of body growth. We also find that TFAM knockdown leads to decreased hemocyte JNK signaling and decreased expression of the TNF alpha homolog, Eiger in hemocytes. Furthermore, we show that genetic knockdown of hemocyte JNK signaling or Eiger expression mimics the effects of TFAM knockdown and leads to a non-autonomous suppression of body size but without altering hemocyte numbers. Our data suggest that modulation of hemocyte mitochondrial metabolism can determine their non-autonomous effects on organismal growth by altering cytokine and systemic insulin signaling. Given that mitochondrial metabolism can be controlled by nutrient availability, our findings may explain how macrophages function as nutrient-responsive regulators of tissue and whole-body physiology and homeostasis." @default.
• W4321018487 created "2023-02-17" @default.
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• W4321018487 date "2023-02-16" @default.
• W4321018487 modified "2023-10-01" @default.
• W4321018487 title "Mitochondrial metabolism in<i>Drosophila</i>macrophage-like cells regulates body growth via modulation of cytokine and insulin signaling" @default.
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• W4321018487 doi "https://doi.org/10.1101/2023.02.15.528747" @default.
• W4321018487 hasPublicationYear "2023" @default.
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