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- W4321021473 abstract "Neurodegenerative disorders are characterized by complex multifactorial pathogeneses, thus posing a challenge for standard therapeutic approaches that tend to focus only on one underlying disease aspect. For systemically administered drugs, the blood–brain barrier (BBB) is yet another major obstacle to overcome. In this context, naturally occurring extracellular vesicles (EVs) with intrinsic ability to cross the BBB have been investigated as therapeutics for various diseases, including Alzheimer's and Parkinson's diseases. EVs are cell-derived, lipid membrane–enclosed vesicles carrying a broad spectrum of biologically active molecules, which play a crucial role in intercellular communication. In a therapeutic context, mesenchymal stem cell (MSC)–derived EVs are in the spotlight because they reflect the therapeutic properties of their parental cells and, thus, hold promise as independent cell–free therapeutics. On the other hand, EVs can be used as drug delivery vehicles by modifying their surface or content, e.g., by decorating the surface with brain-specific ligands or loading the EVs with therapeutic RNAs or proteins, thus further enhancing the EV's targeting and therapeutic potency, respectively. Although EVs have been deemed safe for use in humans, some obstacles remain that prevent their progression into clinics. This review scrutinizes the promises and challenges of EV-based treatments for neurodegenerative disorders." @default.
- W4321021473 created "2023-02-17" @default.
- W4321021473 creator A5032169917 @default.
- W4321021473 creator A5036956935 @default.
- W4321021473 creator A5059897226 @default.
- W4321021473 date "2023-01-01" @default.
- W4321021473 modified "2023-09-30" @default.
- W4321021473 title "Therapeutic potential of extracellular vesicles in neurodegenerative disorders" @default.
- W4321021473 cites W1557444671 @default.
- W4321021473 cites W1588992136 @default.
- W4321021473 cites W1721689174 @default.
- W4321021473 cites W1936506769 @default.
- W4321021473 cites W1967270924 @default.
- W4321021473 cites W1968081342 @default.
- W4321021473 cites W1983199625 @default.
- W4321021473 cites W1990752558 @default.
- W4321021473 cites W1990985572 @default.
- W4321021473 cites W1995037165 @default.
- W4321021473 cites W2009886463 @default.
- W4321021473 cites W2038530570 @default.
- W4321021473 cites W2040635479 @default.
- W4321021473 cites W2041482977 @default.
- W4321021473 cites W2047074480 @default.
- W4321021473 cites W2054446458 @default.
- W4321021473 cites W2058645214 @default.
- W4321021473 cites W2066234893 @default.
- W4321021473 cites W2070693578 @default.
- W4321021473 cites W2071625709 @default.
- W4321021473 cites W2072738655 @default.
- W4321021473 cites W2072899346 @default.
- W4321021473 cites W2078798753 @default.
- W4321021473 cites W2091250479 @default.
- W4321021473 cites W2101495492 @default.
- W4321021473 cites W2112455323 @default.
- W4321021473 cites W2112648950 @default.
- W4321021473 cites W2123771262 @default.
- W4321021473 cites W2124304994 @default.
- W4321021473 cites W2146249493 @default.
- W4321021473 cites W2155366992 @default.
- W4321021473 cites W2158787641 @default.
- W4321021473 cites W2166846320 @default.
- W4321021473 cites W2204571250 @default.
- W4321021473 cites W2271618092 @default.
- W4321021473 cites W2291779372 @default.
- W4321021473 cites W2295697145 @default.
- W4321021473 cites W2401862951 @default.
- W4321021473 cites W2415242066 @default.
- W4321021473 cites W2465939084 @default.
- W4321021473 cites W2476696777 @default.
- W4321021473 cites W2493989888 @default.
- W4321021473 cites W2507172980 @default.
- W4321021473 cites W2511499749 @default.
- W4321021473 cites W2518678169 @default.
- W4321021473 cites W2520511021 @default.
- W4321021473 cites W2563078526 @default.
- W4321021473 cites W2576810421 @default.
- W4321021473 cites W2577340531 @default.
- W4321021473 cites W2607139744 @default.
- W4321021473 cites W2744508753 @default.
- W4321021473 cites W2745482791 @default.
- W4321021473 cites W2756008592 @default.
- W4321021473 cites W2757807906 @default.
- W4321021473 cites W2761961449 @default.
- W4321021473 cites W2774663593 @default.
- W4321021473 cites W2777878363 @default.
- W4321021473 cites W2778203010 @default.
- W4321021473 cites W2791083334 @default.
- W4321021473 cites W2791173772 @default.
- W4321021473 cites W2795523469 @default.
- W4321021473 cites W2795868806 @default.
- W4321021473 cites W2796324227 @default.
- W4321021473 cites W2801941054 @default.
- W4321021473 cites W2806593485 @default.
- W4321021473 cites W2806912433 @default.
- W4321021473 cites W2814481017 @default.
- W4321021473 cites W2888790211 @default.
- W4321021473 cites W2891258623 @default.
- W4321021473 cites W2893115220 @default.
- W4321021473 cites W2900756811 @default.
- W4321021473 cites W2901481809 @default.
- W4321021473 cites W2904668262 @default.
- W4321021473 cites W2907547898 @default.
- W4321021473 cites W2909752226 @default.
- W4321021473 cites W2913892920 @default.
- W4321021473 cites W2923362583 @default.
- W4321021473 cites W2932428906 @default.
- W4321021473 cites W2943517835 @default.
- W4321021473 cites W2944417682 @default.
- W4321021473 cites W2944971749 @default.
- W4321021473 cites W2947491119 @default.
- W4321021473 cites W2964382846 @default.
- W4321021473 cites W2969956278 @default.
- W4321021473 cites W2970563580 @default.
- W4321021473 cites W2972621494 @default.
- W4321021473 cites W2980320219 @default.
- W4321021473 cites W2980841794 @default.
- W4321021473 cites W2984391817 @default.
- W4321021473 cites W2989661489 @default.