FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W43210285> ?p ?o ?g. }

• W43210285 endingPage "179" @default.
• W43210285 startingPage "172" @default.
• W43210285 abstract "Caspase-3 is a major effector protease in several apoptotic pathways, but its role in hypoxic-ischemic (HI) brain injury is incompletely understood. Cerebral HI was induced in 7-day-old rats by unilateral carotid artery ligation and exposure to 7.7% oxygen for 55 min. Caspase-3-like activity was significantly increased at 1 h (208%), peaked at 24 h (2,563%) and was still increased 6 days after HI (169%) in the ipsilateral cerebral cortex. Concomitantly, cleavage of the caspase-3 proform (31/33 kD) was detected on immunoblots, producing 29- and 17-kD fragments. Furthermore, significant degradation of the endogenous caspase-3 substrates inhibitor of caspase-activated DNase (DNA fragmentation factor 45), poly(ADP-ribose) polymerase and fodrin occurred. In conclusion, caspase-3 is activated extensively in the immature brain after HI. The subsequent cleavage of proteins involved in cellular homeostasis and repair may contribute to the process of brain injury." @default.
• W43210285 created "2016-06-24" @default.
• W43210285 creator A5011355109 @default.
• W43210285 creator A5016707135 @default.
• W43210285 creator A5020704914 @default.
• W43210285 creator A5021905275 @default.
• W43210285 creator A5028249851 @default.
• W43210285 creator A5068054602 @default.
• W43210285 date "2001-01-01" @default.
• W43210285 modified "2023-10-16" @default.
• W43210285 title "Caspase-3 Activation after Neonatal Rat Cerebral Hypoxia-Ischemia" @default.
• W43210285 cites W1492302205 @default.
• W43210285 cites W1845459216 @default.
• W43210285 cites W1976467696 @default.
• W43210285 cites W1984616391 @default.
• W43210285 cites W1986727165 @default.
• W43210285 cites W1993414868 @default.
• W43210285 cites W1998934307 @default.
• W43210285 cites W2009926364 @default.
• W43210285 cites W2010298858 @default.
• W43210285 cites W2019802143 @default.
• W43210285 cites W2029394130 @default.
• W43210285 cites W2036158708 @default.
• W43210285 cites W2038813809 @default.
• W43210285 cites W2043674339 @default.
• W43210285 cites W2049110705 @default.
• W43210285 cites W2058776596 @default.
• W43210285 cites W2060069408 @default.
• W43210285 cites W2081145901 @default.
• W43210285 cites W2082259697 @default.
• W43210285 cites W2084948634 @default.
• W43210285 cites W2085758111 @default.
• W43210285 cites W2104543679 @default.
• W43210285 cites W2157874893 @default.
• W43210285 doi "https://doi.org/10.1159/000047087" @default.
• W43210285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11275647" @default.
• W43210285 hasPublicationYear "2001" @default.
• W43210285 type Work @default.
• W43210285 sameAs 43210285 @default.
• W43210285 citedByCount "135" @default.
• W43210285 countsByYear W432102852012 @default.
• W43210285 countsByYear W432102852013 @default.
• W43210285 countsByYear W432102852014 @default.
• W43210285 countsByYear W432102852015 @default.
• W43210285 countsByYear W432102852016 @default.
• W43210285 countsByYear W432102852017 @default.
• W43210285 countsByYear W432102852018 @default.
• W43210285 countsByYear W432102852019 @default.
• W43210285 countsByYear W432102852020 @default.
• W43210285 countsByYear W432102852021 @default.
• W43210285 countsByYear W432102852022 @default.
• W43210285 countsByYear W432102852023 @default.
• W43210285 crossrefType "journal-article" @default.
• W43210285 hasAuthorship W43210285A5011355109 @default.
• W43210285 hasAuthorship W43210285A5016707135 @default.
• W43210285 hasAuthorship W43210285A5020704914 @default.
• W43210285 hasAuthorship W43210285A5021905275 @default.
• W43210285 hasAuthorship W43210285A5028249851 @default.
• W43210285 hasAuthorship W43210285A5068054602 @default.
• W43210285 hasConcept C12519072 @default.
• W43210285 hasConcept C126322002 @default.
• W43210285 hasConcept C134018914 @default.
• W43210285 hasConcept C153911025 @default.
• W43210285 hasConcept C178790620 @default.
• W43210285 hasConcept C179437574 @default.
• W43210285 hasConcept C181199279 @default.
• W43210285 hasConcept C182979987 @default.
• W43210285 hasConcept C185592680 @default.
• W43210285 hasConcept C190283241 @default.
• W43210285 hasConcept C2781041448 @default.
• W43210285 hasConcept C31573885 @default.
• W43210285 hasConcept C43759708 @default.
• W43210285 hasConcept C540031477 @default.
• W43210285 hasConcept C541997718 @default.
• W43210285 hasConcept C55493867 @default.
• W43210285 hasConcept C71924100 @default.
• W43210285 hasConcept C7836513 @default.
• W43210285 hasConcept C82381507 @default.
• W43210285 hasConcept C86803240 @default.
• W43210285 hasConcept C98424977 @default.
• W43210285 hasConceptScore W43210285C12519072 @default.
• W43210285 hasConceptScore W43210285C126322002 @default.
• W43210285 hasConceptScore W43210285C134018914 @default.
• W43210285 hasConceptScore W43210285C153911025 @default.
• W43210285 hasConceptScore W43210285C178790620 @default.
• W43210285 hasConceptScore W43210285C179437574 @default.
• W43210285 hasConceptScore W43210285C181199279 @default.
• W43210285 hasConceptScore W43210285C182979987 @default.
• W43210285 hasConceptScore W43210285C185592680 @default.
• W43210285 hasConceptScore W43210285C190283241 @default.
• W43210285 hasConceptScore W43210285C2781041448 @default.
• W43210285 hasConceptScore W43210285C31573885 @default.
• W43210285 hasConceptScore W43210285C43759708 @default.
• W43210285 hasConceptScore W43210285C540031477 @default.
• W43210285 hasConceptScore W43210285C541997718 @default.
• W43210285 hasConceptScore W43210285C55493867 @default.
• W43210285 hasConceptScore W43210285C71924100 @default.
• W43210285 hasConceptScore W43210285C7836513 @default.

• next