Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321168109> ?p ?o ?g. }
- W4321168109 endingPage "723" @default.
- W4321168109 startingPage "713" @default.
- W4321168109 abstract "Adrenomedullin (AM) is a peptide with pleiotropic physiological functions that attenuates intestinal mucosal inflammation. However, the mechanism underpinning mucosal protection by AM is not fully understood, and its effect on intestinal epithelial cells remains unclear. Here, we investigated the effects of AM on junctional molecules in primary‐cultured murine intestinal epithelial cells and discovered that AM upregulates claudin‐4 expression. In a mouse model of dextran sulfate sodium‐induced colitis, AM administration also enhanced claudin‐4 expression and accelerated mucosal regeneration. Furthermore, AM reversed TNFα‐mediated downregulation of claudin‐4 and loss of cell–cell adhesion of the HCT116 human intestinal epithelial cell line in vitro . These results indicate that AM may enhance intestinal epithelial integrity by upregulating claudin‐4 expression." @default.
- W4321168109 created "2023-02-18" @default.
- W4321168109 creator A5013631866 @default.
- W4321168109 creator A5031353925 @default.
- W4321168109 creator A5032072905 @default.
- W4321168109 creator A5048075263 @default.
- W4321168109 creator A5052117755 @default.
- W4321168109 creator A5053241809 @default.
- W4321168109 creator A5074547508 @default.
- W4321168109 date "2023-02-27" @default.
- W4321168109 modified "2023-09-26" @default.
- W4321168109 title "Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium" @default.
- W4321168109 cites W1498232526 @default.
- W4321168109 cites W1523737655 @default.
- W4321168109 cites W1925706468 @default.
- W4321168109 cites W2006499650 @default.
- W4321168109 cites W2011895759 @default.
- W4321168109 cites W2013580888 @default.
- W4321168109 cites W2017443683 @default.
- W4321168109 cites W2026679422 @default.
- W4321168109 cites W2046717936 @default.
- W4321168109 cites W2047208232 @default.
- W4321168109 cites W2050475327 @default.
- W4321168109 cites W2052891178 @default.
- W4321168109 cites W2056073523 @default.
- W4321168109 cites W2056214437 @default.
- W4321168109 cites W2068132339 @default.
- W4321168109 cites W2076588832 @default.
- W4321168109 cites W2080232509 @default.
- W4321168109 cites W2082439167 @default.
- W4321168109 cites W2092419989 @default.
- W4321168109 cites W2093186917 @default.
- W4321168109 cites W2096789614 @default.
- W4321168109 cites W2104583114 @default.
- W4321168109 cites W2112494031 @default.
- W4321168109 cites W2114033715 @default.
- W4321168109 cites W2137078692 @default.
- W4321168109 cites W2153371932 @default.
- W4321168109 cites W2160427528 @default.
- W4321168109 cites W2165583690 @default.
- W4321168109 cites W2318274488 @default.
- W4321168109 cites W2468200101 @default.
- W4321168109 cites W2470694644 @default.
- W4321168109 cites W2608642635 @default.
- W4321168109 cites W2612876782 @default.
- W4321168109 cites W2766966671 @default.
- W4321168109 cites W2778255765 @default.
- W4321168109 cites W2884742496 @default.
- W4321168109 cites W2897684929 @default.
- W4321168109 cites W2905204949 @default.
- W4321168109 cites W3006796998 @default.
- W4321168109 cites W3095291274 @default.
- W4321168109 cites W3096178006 @default.
- W4321168109 cites W3179089100 @default.
- W4321168109 cites W3194702648 @default.
- W4321168109 cites W4376453094 @default.
- W4321168109 doi "https://doi.org/10.1002/2211-5463.13577" @default.
- W4321168109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36799102" @default.
- W4321168109 hasPublicationYear "2023" @default.
- W4321168109 type Work @default.
- W4321168109 citedByCount "0" @default.
- W4321168109 crossrefType "journal-article" @default.
- W4321168109 hasAuthorship W4321168109A5013631866 @default.
- W4321168109 hasAuthorship W4321168109A5031353925 @default.
- W4321168109 hasAuthorship W4321168109A5032072905 @default.
- W4321168109 hasAuthorship W4321168109A5048075263 @default.
- W4321168109 hasAuthorship W4321168109A5052117755 @default.
- W4321168109 hasAuthorship W4321168109A5053241809 @default.
- W4321168109 hasAuthorship W4321168109A5074547508 @default.
- W4321168109 hasBestOaLocation W43211681091 @default.
- W4321168109 hasConcept C104317684 @default.
- W4321168109 hasConcept C126322002 @default.
- W4321168109 hasConcept C127561419 @default.
- W4321168109 hasConcept C142724271 @default.
- W4321168109 hasConcept C177779419 @default.
- W4321168109 hasConcept C185592680 @default.
- W4321168109 hasConcept C202751555 @default.
- W4321168109 hasConcept C203014093 @default.
- W4321168109 hasConcept C2775862500 @default.
- W4321168109 hasConcept C2776914184 @default.
- W4321168109 hasConcept C2777152744 @default.
- W4321168109 hasConcept C2779281246 @default.
- W4321168109 hasConcept C2781077229 @default.
- W4321168109 hasConcept C3019368612 @default.
- W4321168109 hasConcept C502942594 @default.
- W4321168109 hasConcept C51872919 @default.
- W4321168109 hasConcept C529295009 @default.
- W4321168109 hasConcept C54355233 @default.
- W4321168109 hasConcept C55493867 @default.
- W4321168109 hasConcept C71924100 @default.
- W4321168109 hasConcept C81885089 @default.
- W4321168109 hasConcept C86803240 @default.
- W4321168109 hasConcept C95444343 @default.
- W4321168109 hasConceptScore W4321168109C104317684 @default.
- W4321168109 hasConceptScore W4321168109C126322002 @default.
- W4321168109 hasConceptScore W4321168109C127561419 @default.
- W4321168109 hasConceptScore W4321168109C142724271 @default.
- W4321168109 hasConceptScore W4321168109C177779419 @default.