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- W4321183670 abstract "The development of light-mediated methods for synthetic applications is increasingly attracting high interest. We present herein a new photochemical protocol for the synthesis of hydroxamic acids, which constitute an important class of medicinal agents, mainly due to their anticancer properties. The method is mediated by UVA-light or sunlight and its key point is the generation of a charge transfer complex by the interaction of 4-dimethylaminopyridine with a halomethane. Various carboxylic acids were directly coupled with O-protected hydroxylamines, upon irradiation with either LED 370 nm or solar light. A detailed study of the mechanism was carried out by the employment of direct infusion–high resolution mass spectrometry (DI-HRMS), providing experimental evidence for the formation of various activated species, which may lead to the desired product. The light-mediated protocol was applied in the synthesis of the drugs Vorinostat and Bufexamac." @default.
- W4321183670 created "2023-02-18" @default.
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- W4321183670 date "2023-03-03" @default.
- W4321183670 modified "2023-10-18" @default.
- W4321183670 title "Sunlight‐ or UVA‐Light‐Mediated Synthesis of Hydroxamic Acids from Carboxylic Acids" @default.
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- W4321183670 doi "https://doi.org/10.1002/ejoc.202300046" @default.
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