Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321187012> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4321187012 endingPage "254" @default.
- W4321187012 startingPage "247" @default.
- W4321187012 abstract "Related substances, such as process-related substances and degradation products, may affect the efficacy of drugs and cause adverse reactions. Therefore, identifying and controlling them is of the importance. A rapid ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF–MS) method has been developed for the separation and characterization of related substances in candesartan cilexetil tablets. After optimization, the method validation was followed according to ICH guidelines. The developed UHPLC method showed adequate specificity, sensitivity, accuracy, linearity, precision, stability and robustness for validation of analytical procedures. Commercial candesartan cilexetil tablets was subjected to stress testing (60 ℃, 90% RH and 4500 lx for ten days) and forced degradation studies (acidic, alkaline, oxidative and photolytic degradation conditions). A total of eleven related substances were detected and characterized. Among them, four related substances have not been reported in the literature yet, and one of them (RS7) was confirmed as candesartan cilexetil methoxy analog by reference substance. In addition, plausible mechanisms for the formation of these related substances are discussed. This study provides a useful reference for the quality control of candesartan cilexetil tablets." @default.
- W4321187012 created "2023-02-18" @default.
- W4321187012 creator A5023073272 @default.
- W4321187012 creator A5025103212 @default.
- W4321187012 creator A5034825691 @default.
- W4321187012 creator A5049713859 @default.
- W4321187012 creator A5058328956 @default.
- W4321187012 creator A5062289670 @default.
- W4321187012 creator A5079616569 @default.
- W4321187012 date "2023-02-17" @default.
- W4321187012 modified "2023-09-30" @default.
- W4321187012 title "Separation and Identification of Related Substances in Candesartan Cilexetil Tablets by UHPLC-Q-TOF–MS" @default.
- W4321187012 cites W1971019889 @default.
- W4321187012 cites W1975122674 @default.
- W4321187012 cites W1975769073 @default.
- W4321187012 cites W1976208663 @default.
- W4321187012 cites W1988889966 @default.
- W4321187012 cites W1990919818 @default.
- W4321187012 cites W2060986679 @default.
- W4321187012 cites W26103583 @default.
- W4321187012 cites W2949368282 @default.
- W4321187012 doi "https://doi.org/10.1007/s10337-023-04242-7" @default.
- W4321187012 hasPublicationYear "2023" @default.
- W4321187012 type Work @default.
- W4321187012 citedByCount "0" @default.
- W4321187012 crossrefType "journal-article" @default.
- W4321187012 hasAuthorship W4321187012A5023073272 @default.
- W4321187012 hasAuthorship W4321187012A5025103212 @default.
- W4321187012 hasAuthorship W4321187012A5034825691 @default.
- W4321187012 hasAuthorship W4321187012A5049713859 @default.
- W4321187012 hasAuthorship W4321187012A5058328956 @default.
- W4321187012 hasAuthorship W4321187012A5062289670 @default.
- W4321187012 hasAuthorship W4321187012A5079616569 @default.
- W4321187012 hasBestOaLocation W43211870122 @default.
- W4321187012 hasConcept C162356407 @default.
- W4321187012 hasConcept C170493617 @default.
- W4321187012 hasConcept C185592680 @default.
- W4321187012 hasConcept C2780036600 @default.
- W4321187012 hasConcept C2908929049 @default.
- W4321187012 hasConcept C43617362 @default.
- W4321187012 hasConcept C55493867 @default.
- W4321187012 hasConceptScore W4321187012C162356407 @default.
- W4321187012 hasConceptScore W4321187012C170493617 @default.
- W4321187012 hasConceptScore W4321187012C185592680 @default.
- W4321187012 hasConceptScore W4321187012C2780036600 @default.
- W4321187012 hasConceptScore W4321187012C2908929049 @default.
- W4321187012 hasConceptScore W4321187012C43617362 @default.
- W4321187012 hasConceptScore W4321187012C55493867 @default.
- W4321187012 hasFunder F4320338465 @default.
- W4321187012 hasIssue "3" @default.
- W4321187012 hasLocation W43211870121 @default.
- W4321187012 hasLocation W43211870122 @default.
- W4321187012 hasOpenAccess W4321187012 @default.
- W4321187012 hasPrimaryLocation W43211870121 @default.
- W4321187012 hasRelatedWork W1996545074 @default.
- W4321187012 hasRelatedWork W1999223590 @default.
- W4321187012 hasRelatedWork W2003174742 @default.
- W4321187012 hasRelatedWork W2019498801 @default.
- W4321187012 hasRelatedWork W2043901743 @default.
- W4321187012 hasRelatedWork W2048027784 @default.
- W4321187012 hasRelatedWork W2050262667 @default.
- W4321187012 hasRelatedWork W2087497629 @default.
- W4321187012 hasRelatedWork W2092401104 @default.
- W4321187012 hasRelatedWork W2271539130 @default.
- W4321187012 hasVolume "86" @default.
- W4321187012 isParatext "false" @default.
- W4321187012 isRetracted "false" @default.
- W4321187012 workType "article" @default.