FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321210080> ?p ?o ?g. }

• W4321210080 abstract "The complex mechanism by which stress can affect sensory processes such as hearing is still poorly understood. In a previous study, the mineralocorticoid (MR) and/or glucocorticoid receptor (GR) were deleted in frontal brain regions but not cochlear regions using a CaMKIIα-based tamoxifen-inducible CreERT2/loxP approach. These mice exhibit either a diminished (MRTMXcKO) or disinhibited (GRTMXcKO) auditory nerve activity. In the present study, we observed that mice differentially were (MRTMXcKO) or were not (GRTMXcKO) able to compensate for altered auditory nerve activity in the central auditory pathway. As previous findings demonstrated a link between central auditory compensation and memory-dependent adaptation processes, we analyzed hippocampal paired-pulse facilitation (PPF) and long-term potentiation (LTP). To determine which molecular mechanisms may impact differences in synaptic plasticity, we analyzed Arc/Arg3.1, known to control AMPA receptor trafficking, as well as regulators of tissue perfusion and energy consumption (NO-GC and GC-A). We observed that the changes in PPF of MRTMXcKOs mirrored the changes in their auditory nerve activity, whereas changes in the LTP of MRTMXcKOs and GRTMXcKOs mirrored instead the changes in their central compensation capacity. Enhanced GR expression levels in MRTMXcKOs suggest that MRs typically suppress GR expression. We observed that hippocampal LTP, GC-A mRNA expression levels, and ABR wave IV/I ratio were all enhanced in animals with elevated GR (MRTMXcKOs) but were all lower or not mobilized in animals with impaired GR expression levels (GRTMXcKOs and MRGRTMXcKOs). This suggests that GC-A may link LTP and auditory neural gain through GR-dependent processes. In addition, enhanced NO-GC expression levels in MR, GR, and MRGRTMXcKOs suggest that both receptors suppress NO-GC; on the other hand, elevated Arc/Arg3.1 levels in MRTMXcKOs and MRGRTMXcKOs but not GRTMXcKOs suggest that MR suppresses Arc/Arg3.1 expression levels. Conclusively, MR through GR inhibition may define the threshold for hemodynamic responses for LTP and auditory neural gain associated with GC-A." @default.
• W4321210080 created "2023-02-18" @default.
• W4321210080 creator A5001210140 @default.
• W4321210080 creator A5002961579 @default.
• W4321210080 creator A5007774888 @default.
• W4321210080 creator A5017505906 @default.
• W4321210080 creator A5031003334 @default.
• W4321210080 creator A5046506225 @default.
• W4321210080 creator A5048607283 @default.
• W4321210080 creator A5067688233 @default.
• W4321210080 creator A5077225109 @default.
• W4321210080 creator A5079835977 @default.
• W4321210080 creator A5087372330 @default.
• W4321210080 creator A5087533254 @default.
• W4321210080 date "2023-02-17" @default.
• W4321210080 modified "2023-10-12" @default.
• W4321210080 title "Acute deletion of the central MR/GR steroid receptor correlates with changes in LTP, auditory neural gain, and GC-A cGMP signaling" @default.
• W4321210080 cites W1592313435 @default.
• W4321210080 cites W1607671357 @default.
• W4321210080 cites W1687876312 @default.
• W4321210080 cites W1964189385 @default.
• W4321210080 cites W1965970232 @default.
• W4321210080 cites W1970617230 @default.
• W4321210080 cites W1986381796 @default.
• W4321210080 cites W1988909210 @default.
• W4321210080 cites W1995649690 @default.
• W4321210080 cites W1997278591 @default.
• W4321210080 cites W1999407262 @default.
• W4321210080 cites W2008301967 @default.
• W4321210080 cites W2013185658 @default.
• W4321210080 cites W2025919590 @default.
• W4321210080 cites W2028262137 @default.
• W4321210080 cites W2030040408 @default.
• W4321210080 cites W2030609519 @default.
• W4321210080 cites W2030976437 @default.
• W4321210080 cites W2031875570 @default.
• W4321210080 cites W2032594882 @default.
• W4321210080 cites W2039408689 @default.
• W4321210080 cites W2040650224 @default.
• W4321210080 cites W2043571529 @default.
• W4321210080 cites W2046495130 @default.
• W4321210080 cites W2047347093 @default.
• W4321210080 cites W2048244266 @default.
• W4321210080 cites W2050255961 @default.
• W4321210080 cites W2062842618 @default.
• W4321210080 cites W2062971267 @default.
• W4321210080 cites W2063006154 @default.
• W4321210080 cites W2068246413 @default.
• W4321210080 cites W2071019848 @default.
• W4321210080 cites W2072783665 @default.
• W4321210080 cites W2074802748 @default.
• W4321210080 cites W2085120792 @default.
• W4321210080 cites W2086364410 @default.
• W4321210080 cites W2093400617 @default.
• W4321210080 cites W2093494891 @default.
• W4321210080 cites W2095830332 @default.
• W4321210080 cites W2099829314 @default.
• W4321210080 cites W2100126489 @default.
• W4321210080 cites W2100699923 @default.
• W4321210080 cites W2104179268 @default.
• W4321210080 cites W2110419377 @default.
• W4321210080 cites W2112927743 @default.
• W4321210080 cites W2116629441 @default.
• W4321210080 cites W2121198501 @default.
• W4321210080 cites W2124134616 @default.
• W4321210080 cites W2144601597 @default.
• W4321210080 cites W2147375005 @default.
• W4321210080 cites W2151027504 @default.
• W4321210080 cites W2152983690 @default.
• W4321210080 cites W2163234334 @default.
• W4321210080 cites W2165991867 @default.
• W4321210080 cites W2166623778 @default.
• W4321210080 cites W2169457085 @default.
• W4321210080 cites W2170927128 @default.
• W4321210080 cites W2223647828 @default.
• W4321210080 cites W2246422213 @default.
• W4321210080 cites W2299866425 @default.
• W4321210080 cites W2319350696 @default.
• W4321210080 cites W2513308575 @default.
• W4321210080 cites W2522954781 @default.
• W4321210080 cites W2528836547 @default.
• W4321210080 cites W2581158021 @default.
• W4321210080 cites W2610621727 @default.
• W4321210080 cites W2611778409 @default.
• W4321210080 cites W2616216465 @default.
• W4321210080 cites W2752474988 @default.
• W4321210080 cites W2759053637 @default.
• W4321210080 cites W2778754068 @default.
• W4321210080 cites W2787949518 @default.
• W4321210080 cites W2792973160 @default.
• W4321210080 cites W2794348911 @default.
• W4321210080 cites W2800725866 @default.
• W4321210080 cites W2804388674 @default.
• W4321210080 cites W2806453509 @default.
• W4321210080 cites W2809036469 @default.
• W4321210080 cites W2882341351 @default.
• W4321210080 cites W2885183257 @default.
• W4321210080 cites W2890422976 @default.
• W4321210080 cites W2901068560 @default.
• W4321210080 cites W2905634942 @default.

• next