Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321250427> ?p ?o ?g. }
- W4321250427 endingPage "35" @default.
- W4321250427 startingPage "27" @default.
- W4321250427 abstract "Abstract Background Sarcopenia is characterized by the progressive and generalized loss of muscle mass and function. There is an increasing body of evidence to suggest that cancer patients with pre‐existing sarcopenia are at a greater risk of both short‐ and long‐term clinical complications. The aim of this review is to examine the impact of low muscle mass on prognostic outcomes in patients with locally advanced rectal cancer (LARC) who undergo neoadjuvant chemoradiotherapy (nCRT) prior to surgery. Methods MEDLINE, PubMed, and Embase databases were searched from inception to October 2021. Any comparative studies relating to the prognostic outcomes of sarcopenic versus non‐sarcopenic patients with LARC who received nCRT prior to surgery were included. Risk of bias was assessed using the Risk Of Bias In Non‐randomized Studies of Interventions (ROBINS‐I). Meta‐analysis was performed on reported hazard ratios (HR) and 95% confidence intervals (CI) using DerSimonian–Laird random‐effects models. Results A total of 598 patients from five studies were included in the analysis of hazard ratios for overall survival, whereas 505 patients from four studies were available for analysis of HR for disease‐free survival. Meta‐regression analysis showed a significant association between pre‐existing sarcopenia and worse overall survival (HR: 1.69, 95% CI: 1.15–2.48). The association between pre‐existing sarcopenia and shorter disease‐free survival was not statistically significant (HR: 1.07, 95% CI: 0.63–1.82). Conclusions The review highlights the role that body composition can play on prognostic outcomes in patients undergoing multimodal cancer treatment. Given the complex underpinnings of sarcopenia progression, more research is needed to develop strategies to mitigate this impact in a physiologically vulnerable population." @default.
- W4321250427 created "2023-02-18" @default.
- W4321250427 creator A5025547300 @default.
- W4321250427 creator A5042165632 @default.
- W4321250427 creator A5050794394 @default.
- W4321250427 creator A5052637105 @default.
- W4321250427 creator A5053626140 @default.
- W4321250427 creator A5086031055 @default.
- W4321250427 date "2023-02-17" @default.
- W4321250427 modified "2023-10-14" @default.
- W4321250427 title "The impact of low muscle mass on prognosis following neoadjuvant chemotherapy for resectable locally advanced rectal cancer: a systematic review and meta‐analysis" @default.
- W4321250427 cites W1828411566 @default.
- W4321250427 cites W1865433224 @default.
- W4321250427 cites W1985388571 @default.
- W4321250427 cites W1988539555 @default.
- W4321250427 cites W2003064100 @default.
- W4321250427 cites W2013439462 @default.
- W4321250427 cites W2019483360 @default.
- W4321250427 cites W2037102067 @default.
- W4321250427 cites W2043737378 @default.
- W4321250427 cites W2051331668 @default.
- W4321250427 cites W2085209022 @default.
- W4321250427 cites W2118224153 @default.
- W4321250427 cites W2118558111 @default.
- W4321250427 cites W2126077851 @default.
- W4321250427 cites W2127424726 @default.
- W4321250427 cites W2130451039 @default.
- W4321250427 cites W2137687978 @default.
- W4321250427 cites W2156047796 @default.
- W4321250427 cites W2166974345 @default.
- W4321250427 cites W2268912046 @default.
- W4321250427 cites W2279428213 @default.
- W4321250427 cites W2306195164 @default.
- W4321250427 cites W2318273401 @default.
- W4321250427 cites W2529732846 @default.
- W4321250427 cites W2531269403 @default.
- W4321250427 cites W2560438049 @default.
- W4321250427 cites W2562154761 @default.
- W4321250427 cites W2575149425 @default.
- W4321250427 cites W2734494495 @default.
- W4321250427 cites W2749906555 @default.
- W4321250427 cites W2751704934 @default.
- W4321250427 cites W2797298358 @default.
- W4321250427 cites W2799467895 @default.
- W4321250427 cites W2799850189 @default.
- W4321250427 cites W2801534684 @default.
- W4321250427 cites W2805039612 @default.
- W4321250427 cites W2805442081 @default.
- W4321250427 cites W2889618781 @default.
- W4321250427 cites W2892518805 @default.
- W4321250427 cites W2897513125 @default.
- W4321250427 cites W2923834234 @default.
- W4321250427 cites W2951306207 @default.
- W4321250427 cites W2982669953 @default.
- W4321250427 cites W2984916487 @default.
- W4321250427 cites W2989594449 @default.
- W4321250427 cites W2990915089 @default.
- W4321250427 cites W3123963973 @default.
- W4321250427 cites W314798373 @default.
- W4321250427 cites W3207987720 @default.
- W4321250427 cites W3210850384 @default.
- W4321250427 cites W4210927377 @default.
- W4321250427 cites W4211168195 @default.
- W4321250427 cites W4294215472 @default.
- W4321250427 doi "https://doi.org/10.1002/crt2.59" @default.
- W4321250427 hasPublicationYear "2023" @default.
- W4321250427 type Work @default.
- W4321250427 citedByCount "0" @default.
- W4321250427 crossrefType "journal-article" @default.
- W4321250427 hasAuthorship W4321250427A5025547300 @default.
- W4321250427 hasAuthorship W4321250427A5042165632 @default.
- W4321250427 hasAuthorship W4321250427A5050794394 @default.
- W4321250427 hasAuthorship W4321250427A5052637105 @default.
- W4321250427 hasAuthorship W4321250427A5053626140 @default.
- W4321250427 hasAuthorship W4321250427A5086031055 @default.
- W4321250427 hasBestOaLocation W43212504271 @default.
- W4321250427 hasConcept C121608353 @default.
- W4321250427 hasConcept C126322002 @default.
- W4321250427 hasConcept C141071460 @default.
- W4321250427 hasConcept C143998085 @default.
- W4321250427 hasConcept C207103383 @default.
- W4321250427 hasConcept C2776214593 @default.
- W4321250427 hasConcept C2778424827 @default.
- W4321250427 hasConcept C44249647 @default.
- W4321250427 hasConcept C50382708 @default.
- W4321250427 hasConcept C526805850 @default.
- W4321250427 hasConcept C71924100 @default.
- W4321250427 hasConcept C82789193 @default.
- W4321250427 hasConcept C95190672 @default.
- W4321250427 hasConceptScore W4321250427C121608353 @default.
- W4321250427 hasConceptScore W4321250427C126322002 @default.
- W4321250427 hasConceptScore W4321250427C141071460 @default.
- W4321250427 hasConceptScore W4321250427C143998085 @default.
- W4321250427 hasConceptScore W4321250427C207103383 @default.
- W4321250427 hasConceptScore W4321250427C2776214593 @default.
- W4321250427 hasConceptScore W4321250427C2778424827 @default.
- W4321250427 hasConceptScore W4321250427C44249647 @default.
- W4321250427 hasConceptScore W4321250427C50382708 @default.