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• W4321250947 startingPage "54" @default.
• W4321250947 abstract "Inflammation is a crucial step prior to healing, and the regulatory effects of endodontic materials on the immune response can influence tissue repair. This review aimed to answer whether endodontic sealers can modulate the immune cells and inflammation. An electronic search in Scopus, Web of Science, PubMed, and Google Scholar databases were performed. This systematic review was mainly based on PRISMA guidelines, and the risk of bias was evaluated by SYRCLEs and the Modified CONSORT checklist for in vivo and in vitro studies, respectively. In total, 28 articles: 22 in vitro studies, and six in vivo studies were included in this systematic review. AH Plus and AH 26 can down-regulate iNOS mRNA, while S-PRG sealers can down-regulate p65 of NF-κB pathways to inhibit the production of TNF-α, IL-1, and IL-6. In vitro and in vivo studies suggested that various endodontic sealers exhibited immunomodulatory impact in macrophages polarization and inflammatory cytokine production, which could promote healing, tissue repair, and inhibit inflammation. Since the paradigm change from immune inert biomaterials to bioactive materials, endodontic materials, particularly sealers, are required to have modulatory effects in clinical conditions. New generations of endodontic sealers could hamper detrimental inflammatory responses and maintain periodontal tissue, which represent a breakthrough in biocompatibility and functionality of endodontic biomaterials." @default.
• W4321250947 created "2023-02-18" @default.
• W4321250947 creator A5013485004 @default.
• W4321250947 creator A5040862229 @default.
• W4321250947 creator A5079826288 @default.
• W4321250947 date "2023-02-17" @default.
• W4321250947 modified "2023-10-18" @default.
• W4321250947 title "Immunomodulatory Effects of Endodontic Sealers: A Systematic Review" @default.
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• W4321250947 doi "https://doi.org/10.3390/dj11020054" @default.
• W4321250947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36826199" @default.
• W4321250947 hasPublicationYear "2023" @default.
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