FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321327303> ?p ?o ?g. }

• W4321327303 abstract "Observational studies have demonstrated that basal metabolic rate (BMR) is associated with the risk of endometrial cancer (EC) and ovarian cancer (OC). However, it is unclear whether these associations reflect a causal relationship.To reveal the causality between BMR and EC and OC, we performed the first comprehensive two-sample Mendelian randomization (MR) analyses.Genetic variants were used as proxies of BMR. GWAS summary statistics of BMR, EC and OC were obtained from the UK Biobank Consortium, Endometrial Cancer Association Consortium and Ovarian Cancer Association Consortium respectively. The inverse variance weighted method was employed as the main approach for MR analysis. A series of sensitivity analyses were implemented to validate the robustness and reliability of the results.BMR was significantly related to an increased risk of EC (ORSD = 1.49; 95% CI: 1.29-1.72; p-Value < .001) and OC (ORSD = 1.21; 95% CI: 1.08-1.35; p-Value < .001). Furthermore, the stratified analysis indicated that BMR was positively associated with endometrioid endometrial cancer (EEC) (ORSD = 1.45; 95% CI, 1.23-1.70; p-Value < .001), clear cell ovarian cancer(CCOC) (ORSD = 1.89; 95% CI:1.35-2.64; p-Value < .001) and endometrioid ovarian cancer risk (EOC) (ORSD = 1.45; 95% CI: 1.12-1.88; p-Value = .005). However, there were no significant associations of BMR with invasive mucinous ovarian cancer (IMOC), high-grade serous ovarian cancer (HGSOC) and low-grade serous ovarian cancer (LGSOC). The robustness of the above results was further verified in sensitivity analyses.The MR study provided etiological evidence for the positive association of BMR with the risk of EC, EEC, OC, CCOC and EOC. But this study did not provide enough evidence suggesting the causal associations of BMR with IMOC, HGSOC and LGSOC." @default.
• W4321327303 created "2023-02-19" @default.
• W4321327303 creator A5017087977 @default.
• W4321327303 creator A5037197129 @default.
• W4321327303 creator A5051764626 @default.
• W4321327303 creator A5054981705 @default.
• W4321327303 date "2023-03-02" @default.
• W4321327303 modified "2023-10-01" @default.
• W4321327303 title "Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: Analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK biobank participants" @default.
• W4321327303 cites W1964472634 @default.
• W4321327303 cites W1972696558 @default.
• W4321327303 cites W1979414771 @default.
• W4321327303 cites W1983259675 @default.
• W4321327303 cites W1993924131 @default.
• W4321327303 cites W1994518954 @default.
• W4321327303 cites W2020405138 @default.
• W4321327303 cites W2057922704 @default.
• W4321327303 cites W2079085536 @default.
• W4321327303 cites W2091272291 @default.
• W4321327303 cites W2103680156 @default.
• W4321327303 cites W2103783427 @default.
• W4321327303 cites W2105665764 @default.
• W4321327303 cites W2106036991 @default.
• W4321327303 cites W2118008714 @default.
• W4321327303 cites W2124821727 @default.
• W4321327303 cites W2150452688 @default.
• W4321327303 cites W2158304798 @default.
• W4321327303 cites W2166082348 @default.
• W4321327303 cites W2306906617 @default.
• W4321327303 cites W2324862792 @default.
• W4321327303 cites W2328393125 @default.
• W4321327303 cites W2334711708 @default.
• W4321327303 cites W2583218221 @default.
• W4321327303 cites W2601822003 @default.
• W4321327303 cites W2614566443 @default.
• W4321327303 cites W2617218109 @default.
• W4321327303 cites W2758760080 @default.
• W4321327303 cites W2765952964 @default.
• W4321327303 cites W2770598799 @default.
• W4321327303 cites W2773927148 @default.
• W4321327303 cites W2803072880 @default.
• W4321327303 cites W2805983714 @default.
• W4321327303 cites W2886497950 @default.
• W4321327303 cites W2889646458 @default.
• W4321327303 cites W2897522485 @default.
• W4321327303 cites W2949543964 @default.
• W4321327303 cites W2950124092 @default.
• W4321327303 cites W2950885009 @default.
• W4321327303 cites W2981330428 @default.
• W4321327303 cites W2996132607 @default.
• W4321327303 cites W3042936392 @default.
• W4321327303 cites W3119005666 @default.
• W4321327303 cites W3128646645 @default.
• W4321327303 cites W3199229023 @default.
• W4321327303 cites W3202382702 @default.
• W4321327303 cites W4206841660 @default.
• W4321327303 cites W4210987384 @default.
• W4321327303 cites W4253754191 @default.
• W4321327303 cites W4255815262 @default.
• W4321327303 cites W565843157 @default.
• W4321327303 doi "https://doi.org/10.1111/eci.13971" @default.
• W4321327303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36807123" @default.
• W4321327303 hasPublicationYear "2023" @default.
• W4321327303 type Work @default.
• W4321327303 citedByCount "2" @default.
• W4321327303 countsByYear W43213273032023 @default.
• W4321327303 crossrefType "journal-article" @default.
• W4321327303 hasAuthorship W4321327303A5017087977 @default.
• W4321327303 hasAuthorship W4321327303A5037197129 @default.
• W4321327303 hasAuthorship W4321327303A5051764626 @default.
• W4321327303 hasAuthorship W4321327303A5054981705 @default.
• W4321327303 hasConcept C104317684 @default.
• W4321327303 hasConcept C121608353 @default.
• W4321327303 hasConcept C126322002 @default.
• W4321327303 hasConcept C135763542 @default.
• W4321327303 hasConcept C143998085 @default.
• W4321327303 hasConcept C150173356 @default.
• W4321327303 hasConcept C2777088508 @default.
• W4321327303 hasConcept C2779901538 @default.
• W4321327303 hasConcept C2780427987 @default.
• W4321327303 hasConcept C29456083 @default.
• W4321327303 hasConcept C2993967602 @default.
• W4321327303 hasConcept C54355233 @default.
• W4321327303 hasConcept C71924100 @default.
• W4321327303 hasConcept C86803240 @default.
• W4321327303 hasConceptScore W4321327303C104317684 @default.
• W4321327303 hasConceptScore W4321327303C121608353 @default.
• W4321327303 hasConceptScore W4321327303C126322002 @default.
• W4321327303 hasConceptScore W4321327303C135763542 @default.
• W4321327303 hasConceptScore W4321327303C143998085 @default.
• W4321327303 hasConceptScore W4321327303C150173356 @default.
• W4321327303 hasConceptScore W4321327303C2777088508 @default.
• W4321327303 hasConceptScore W4321327303C2779901538 @default.
• W4321327303 hasConceptScore W4321327303C2780427987 @default.
• W4321327303 hasConceptScore W4321327303C29456083 @default.
• W4321327303 hasConceptScore W4321327303C2993967602 @default.
• W4321327303 hasConceptScore W4321327303C54355233 @default.
• W4321327303 hasConceptScore W4321327303C71924100 @default.
• W4321327303 hasConceptScore W4321327303C86803240 @default.
• W4321327303 hasLocation W43213273031 @default.

• next