FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321328071> ?p ?o ?g. }

• W4321328071 abstract "Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by Western diet (WD) intake. The current study uncovers the molecular signatures for diet and age-linked metabolic liver disease development in an FXR-dependent manner.Wild-type (WT) and FXR KO male mice, either on a healthy control diet (CD) or a WD, were euthanized at the ages of 5, 10, or 15 months. Hepatic transcriptomics, liver, serum, and urine metabolomics as well as microbiota were profiled.WD intake facilitated hepatic aging in WT mice. In an FXR-dependent manner, increased inflammation and reduced oxidative phosphorylation were the primary pathways affected by WD and aging. FXR has a role in modulating inflammation and B cell-mediated humoral immunity which was enhanced by aging. Moreover, FXR dictated neuron differentiation, muscle contraction, and cytoskeleton organization in addition to metabolism. There were 654 transcripts commonly altered by diets, ages, and FXR KO, and 76 of them were differentially expressed in human hepatocellular carcinoma (HCC) and healthy livers. Urine metabolites differentiated dietary effects in both genotypes, and serum metabolites clearly separated ages irrespective of diets. Aging and FXR KO commonly affected amino acid metabolism and TCA cycle. Moreover, FXR is essential for colonization of age-related gut microbes. Integrated analyses uncovered metabolites and bacteria linked with hepatic transcripts affected by WD intake, aging, and FXR KO as well as related to HCC patient survival.FXR is a target to prevent diet or age-associated metabolic disease. The uncovered metabolites and microbes can be diagnostic markers for metabolic disease." @default.
• W4321328071 created "2023-02-19" @default.
• W4321328071 creator A5000966901 @default.
• W4321328071 creator A5014531718 @default.
• W4321328071 creator A5036116332 @default.
• W4321328071 creator A5047794053 @default.
• W4321328071 creator A5049237055 @default.
• W4321328071 creator A5064226135 @default.
• W4321328071 creator A5071796211 @default.
• W4321328071 creator A5078004886 @default.
• W4321328071 creator A5078051933 @default.
• W4321328071 date "2023-02-18" @default.
• W4321328071 modified "2023-10-05" @default.
• W4321328071 title "The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study" @default.
• W4321328071 cites W1575469908 @default.
• W4321328071 cites W1590750098 @default.
• W4321328071 cites W1976072516 @default.
• W4321328071 cites W1981460639 @default.
• W4321328071 cites W2001086489 @default.
• W4321328071 cites W2002364623 @default.
• W4321328071 cites W2015207387 @default.
• W4321328071 cites W2051040521 @default.
• W4321328071 cites W2075818472 @default.
• W4321328071 cites W2077338924 @default.
• W4321328071 cites W2097051959 @default.
• W4321328071 cites W2097249983 @default.
• W4321328071 cites W2130410032 @default.
• W4321328071 cites W2140550112 @default.
• W4321328071 cites W2148713009 @default.
• W4321328071 cites W2159496628 @default.
• W4321328071 cites W2166661344 @default.
• W4321328071 cites W2197124664 @default.
• W4321328071 cites W2313583633 @default.
• W4321328071 cites W2497208646 @default.
• W4321328071 cites W2592811885 @default.
• W4321328071 cites W2606155821 @default.
• W4321328071 cites W2610202165 @default.
• W4321328071 cites W2610709313 @default.
• W4321328071 cites W2734974018 @default.
• W4321328071 cites W2748864304 @default.
• W4321328071 cites W2751089373 @default.
• W4321328071 cites W2754032461 @default.
• W4321328071 cites W2804422202 @default.
• W4321328071 cites W2806484073 @default.
• W4321328071 cites W2884584226 @default.
• W4321328071 cites W2913268077 @default.
• W4321328071 cites W2919326905 @default.
• W4321328071 cites W2946264652 @default.
• W4321328071 cites W2950221693 @default.
• W4321328071 cites W2952334279 @default.
• W4321328071 cites W2979841773 @default.
• W4321328071 cites W2984929339 @default.
• W4321328071 cites W2986365669 @default.
• W4321328071 cites W2989579565 @default.
• W4321328071 cites W3005624705 @default.
• W4321328071 cites W3005849052 @default.
• W4321328071 cites W3045114299 @default.
• W4321328071 cites W3083479704 @default.
• W4321328071 cites W3085758172 @default.
• W4321328071 cites W3095332515 @default.
• W4321328071 cites W3109500484 @default.
• W4321328071 cites W3116613840 @default.
• W4321328071 cites W3127481819 @default.
• W4321328071 cites W3135079633 @default.
• W4321328071 cites W3137441476 @default.
• W4321328071 cites W3163776584 @default.
• W4321328071 cites W3169648159 @default.
• W4321328071 cites W3193498370 @default.
• W4321328071 cites W3194117947 @default.
• W4321328071 cites W3208624945 @default.
• W4321328071 cites W4205605857 @default.
• W4321328071 cites W4206276097 @default.
• W4321328071 cites W4281555356 @default.
• W4321328071 doi "https://doi.org/10.1186/s40364-023-00458-9" @default.
• W4321328071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36803569" @default.
• W4321328071 hasPublicationYear "2023" @default.
• W4321328071 type Work @default.
• W4321328071 citedByCount "2" @default.
• W4321328071 countsByYear W43213280712023 @default.
• W4321328071 crossrefType "journal-article" @default.
• W4321328071 hasAuthorship W4321328071A5000966901 @default.
• W4321328071 hasAuthorship W4321328071A5014531718 @default.
• W4321328071 hasAuthorship W4321328071A5036116332 @default.
• W4321328071 hasAuthorship W4321328071A5047794053 @default.
• W4321328071 hasAuthorship W4321328071A5049237055 @default.
• W4321328071 hasAuthorship W4321328071A5064226135 @default.
• W4321328071 hasAuthorship W4321328071A5071796211 @default.
• W4321328071 hasAuthorship W4321328071A5078004886 @default.
• W4321328071 hasAuthorship W4321328071A5078051933 @default.
• W4321328071 hasBestOaLocation W43213280711 @default.
• W4321328071 hasConcept C104317684 @default.
• W4321328071 hasConcept C126322002 @default.
• W4321328071 hasConcept C134018914 @default.
• W4321328071 hasConcept C150194340 @default.
• W4321328071 hasConcept C162317418 @default.
• W4321328071 hasConcept C203014093 @default.
• W4321328071 hasConcept C203862802 @default.
• W4321328071 hasConcept C21565614 @default.
• W4321328071 hasConcept C2779399885 @default.
• W4321328071 hasConcept C539455810 @default.

• next