FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321330686> ?p ?o ?g. }

• W4321330686 endingPage "29" @default.
• W4321330686 startingPage "1" @default.
• W4321330686 abstract "The molecular classification of HCC premised on metabolic genes might give assistance for diagnosis, therapy, prognosis prediction, immune infiltration, and oxidative stress in addition to supplementing the limitations of the clinical staging system. This would help to better represent the deeper features of HCC.TCGA datasets combined with GSE14520 and HCCDB18 datasets were used to determine the metabolic subtype (MC) using ConsensusClusterPlus. ssGSEA method was used to calculate the IFNγ score, the oxidative stress pathway scores, and the score distribution of 22 distinct immune cells, and their differential expressions were assessed with the use of CIBERSORT. To generate a subtype classification feature index, LDA was utilized. Screening of the metabolic gene coexpression modules was done with the help of WGCNA.Three MCs (MC1, MC2, and MC3) were identified and showed different prognoses (MC2-poor and MC1-better). Although MC2 had a high immune microenvironment infiltration, T cell exhaustion markers were expressed at a high level in MC2 in contrast with MC1. Most oxidative stress-related pathways are inhibited in the MC2 subtype and activated in the MC1 subtype. The immunophenotyping of pan-cancer showed that the C1 and C2 subtypes with poor prognosis accounted for significantly higher proportions of MC2 and MC3 subtypes than MC1, while the better prognostic C3 subtype accounted for significantly lower proportions of MC2 than MC1. As per the findings of the TIDE analysis, MC1 had a greater likelihood of benefiting from immunotherapeutic regimens. MC2 was found to have a greater sensitivity to traditional chemotherapy drugs. Finally, 7 potential gene markers indicate HCC prognosis.The difference (variation) in tumor microenvironment and oxidative stress among metabolic subtypes of HCC was compared from multiple angles and levels. A complete and thorough clarification of the molecular pathological properties of HCC, the exploration of reliable markers for diagnosis, the improvement of the cancer staging system, and the guiding of individualized treatment of HCC all gain benefit greatly from molecular classification associated with metabolism." @default.
• W4321330686 created "2023-02-19" @default.
• W4321330686 creator A5000325321 @default.
• W4321330686 creator A5020298467 @default.
• W4321330686 creator A5043426980 @default.
• W4321330686 creator A5064864855 @default.
• W4321330686 creator A5068451283 @default.
• W4321330686 creator A5075296283 @default.
• W4321330686 creator A5087228140 @default.
• W4321330686 creator A5088393611 @default.
• W4321330686 creator A5089795720 @default.
• W4321330686 date "2023-02-18" @default.
• W4321330686 modified "2023-10-16" @default.
• W4321330686 title "Development of Prognostic Features of Hepatocellular Carcinoma Based on Metabolic Gene Classification and Immune and Oxidative Stress Characteristic Analysis" @default.
• W4321330686 cites W1544233162 @default.
• W4321330686 cites W1859257957 @default.
• W4321330686 cites W1883333379 @default.
• W4321330686 cites W1964185091 @default.
• W4321330686 cites W1971620413 @default.
• W4321330686 cites W1982154889 @default.
• W4321330686 cites W1995501999 @default.
• W4321330686 cites W2014058353 @default.
• W4321330686 cites W2028433016 @default.
• W4321330686 cites W2032166347 @default.
• W4321330686 cites W2037649542 @default.
• W4321330686 cites W2046257690 @default.
• W4321330686 cites W2046427987 @default.
• W4321330686 cites W2046623913 @default.
• W4321330686 cites W2049491375 @default.
• W4321330686 cites W2058759044 @default.
• W4321330686 cites W2068872402 @default.
• W4321330686 cites W2069447948 @default.
• W4321330686 cites W2070323020 @default.
• W4321330686 cites W2095835903 @default.
• W4321330686 cites W2097177355 @default.
• W4321330686 cites W2097855813 @default.
• W4321330686 cites W2105345155 @default.
• W4321330686 cites W2108018825 @default.
• W4321330686 cites W2117692326 @default.
• W4321330686 cites W2127712585 @default.
• W4321330686 cites W2137318335 @default.
• W4321330686 cites W2147296479 @default.
• W4321330686 cites W2158378236 @default.
• W4321330686 cites W2162501548 @default.
• W4321330686 cites W2194546364 @default.
• W4321330686 cites W2203982515 @default.
• W4321330686 cites W2234115940 @default.
• W4321330686 cites W2316882218 @default.
• W4321330686 cites W2345381093 @default.
• W4321330686 cites W2588082084 @default.
• W4321330686 cites W2603697780 @default.
• W4321330686 cites W2612431515 @default.
• W4321330686 cites W2622008929 @default.
• W4321330686 cites W2625559053 @default.
• W4321330686 cites W2750064419 @default.
• W4321330686 cites W2782753012 @default.
• W4321330686 cites W2790599519 @default.
• W4321330686 cites W2796153225 @default.
• W4321330686 cites W2796207838 @default.
• W4321330686 cites W2898314774 @default.
• W4321330686 cites W2902846316 @default.
• W4321330686 cites W2913062750 @default.
• W4321330686 cites W2943074432 @default.
• W4321330686 cites W2972096813 @default.
• W4321330686 cites W2990250467 @default.
• W4321330686 cites W2999626196 @default.
• W4321330686 cites W3000080936 @default.
• W4321330686 cites W3035999666 @default.
• W4321330686 cites W4210955410 @default.
• W4321330686 cites W4241691035 @default.
• W4321330686 doi "https://doi.org/10.1155/2023/1847700" @default.
• W4321330686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36860731" @default.
• W4321330686 hasPublicationYear "2023" @default.
• W4321330686 type Work @default.
• W4321330686 citedByCount "1" @default.
• W4321330686 countsByYear W43213306862023 @default.
• W4321330686 crossrefType "journal-article" @default.
• W4321330686 hasAuthorship W4321330686A5000325321 @default.
• W4321330686 hasAuthorship W4321330686A5020298467 @default.
• W4321330686 hasAuthorship W4321330686A5043426980 @default.
• W4321330686 hasAuthorship W4321330686A5064864855 @default.
• W4321330686 hasAuthorship W4321330686A5068451283 @default.
• W4321330686 hasAuthorship W4321330686A5075296283 @default.
• W4321330686 hasAuthorship W4321330686A5087228140 @default.
• W4321330686 hasAuthorship W4321330686A5088393611 @default.
• W4321330686 hasAuthorship W4321330686A5089795720 @default.
• W4321330686 hasBestOaLocation W43213306861 @default.
• W4321330686 hasConcept C104317684 @default.
• W4321330686 hasConcept C126322002 @default.
• W4321330686 hasConcept C134018914 @default.
• W4321330686 hasConcept C143998085 @default.
• W4321330686 hasConcept C147483822 @default.
• W4321330686 hasConcept C196166836 @default.
• W4321330686 hasConcept C203014093 @default.
• W4321330686 hasConcept C2776151105 @default.
• W4321330686 hasConcept C2778019345 @default.
• W4321330686 hasConcept C502942594 @default.
• W4321330686 hasConcept C54355233 @default.

• next