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- W4321330983 abstract "Abstract The hippocampus executes imperative functions from declarative memory to adaptive behaviors associated with cognition and emotion. However, the mechanisms of how morphogenesis and functions along the hippocampal dorsoventral axis are differentiated and integrated are still largely unclear. Here, we show that COUP-TFI and -TFII genes are distinctively expressed in the dorsal and ventral hippocampus, respectively. The loss of COUP-TFII results in ectopic CA1/CA3 domains in the ventral hippocampus. The deficiency of COUP-TFI leads to the failed specification of dorsal CA1, among which there are place cells. The deletion of both COUP-TF genes causes almost agenesis of the hippocampus with abnormalities of trisynaptic circuit and adult neurogenesis. Moreover, COUP-TFI / -TFII may cooperate to guarantee appropriate morphogenesis and function of the hippocampus by regulating the Lhx5-Lhx2 axis. Our findings revealed a novel mechanism that COUP-TFI and COUP-TFII converge to govern the differentiation and integration of distinct characteristics of the hippocampus in mice." @default.
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- W4321330983 date "2023-02-17" @default.
- W4321330983 modified "2023-09-26" @default.
- W4321330983 title "The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes" @default.
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- W4321330983 doi "https://doi.org/10.1101/2023.02.17.528915" @default.
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