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• W4321330994 abstract "ACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection." @default.
• W4321330994 created "2023-02-19" @default.
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• W4321330994 date "2023-02-18" @default.
• W4321330994 modified "2023-10-15" @default.
• W4321330994 title "Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis" @default.
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• W4321330994 doi "https://doi.org/10.1038/s41698-023-00361-4" @default.
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