FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321354447> ?p ?o ?g. }

• W4321354447 endingPage "98" @default.
• W4321354447 startingPage "92" @default.
• W4321354447 abstract "Studies have suggested that fingolimod, a sphingosine-1-phosphate receptor modulator, exerts neuroprotective and anti-inflammatory effects. Although fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis, limited studies have investigated its effects in patients with schizophrenia. This study investigated the efficacy and safety of fingolimod adjuvant to risperidone in schizophrenia treatment.This eight-week, randomized, double-blinded, placebo-controlled trial included 80 (clinical trials registry code: IRCT20090117001556N137) patients with chronic schizophrenia. Participants were assigned to two equal arms and received risperidone plus either fingolimod (0.5 mg/day) or a matched placebo. The positive and negative symptom scale (PANSS) was used to measure and compare the effectiveness of treatment strategies at baseline and weeks 2, 4, 6, and 8. Treatment side effects were also compared.Seventy participants completed the trial (35 in each arm). The baseline characteristics of the groups were comparable (P-value > 0.05). There were significant time-treatment interaction effects on negative symptoms (P-value = 0.003), general symptoms (P-value = 0.037), and the PANSS total score (P-value = 0.035), suggesting greater improvement in symptoms following the fingolimod adjuvant therapy. In contrast, the longitudinal changes in positive and depressive symptoms were similar between the groups (P-values > 0.05). Regarding the safety of treatments, there were no differences in extrapyramidal symptoms [assessed by the extrapyramidal symptom rating scale (ESRS)] or frequency of other complications between the fingolimod and the placebo groups (P-values > 0.05).This study indicated that fingolimod is a safe and effective adjuvant agent for schizophrenia treatment. However, further clinical trials are required to suggest extensive clinical application." @default.
• W4321354447 created "2023-02-20" @default.
• W4321354447 creator A5001428893 @default.
• W4321354447 creator A5003741699 @default.
• W4321354447 creator A5008181440 @default.
• W4321354447 creator A5025427272 @default.
• W4321354447 creator A5031106277 @default.
• W4321354447 creator A5046823287 @default.
• W4321354447 creator A5067824967 @default.
• W4321354447 creator A5073521992 @default.
• W4321354447 creator A5081859146 @default.
• W4321354447 creator A5088810181 @default.
• W4321354447 date "2023-04-01" @default.
• W4321354447 modified "2023-10-01" @default.
• W4321354447 title "Efficacy and safety of adjunctive therapy with fingolimod in patients with schizophrenia: A randomized, double-blind, placebo-controlled clinical trial" @default.
• W4321354447 cites W1963580478 @default.
• W4321354447 cites W1982058167 @default.
• W4321354447 cites W1987479248 @default.
• W4321354447 cites W2018838561 @default.
• W4321354447 cites W2030396834 @default.
• W4321354447 cites W2042755650 @default.
• W4321354447 cites W2053141907 @default.
• W4321354447 cites W2055081835 @default.
• W4321354447 cites W2069673779 @default.
• W4321354447 cites W2077001392 @default.
• W4321354447 cites W2091960711 @default.
• W4321354447 cites W2098234649 @default.
• W4321354447 cites W2104948944 @default.
• W4321354447 cites W2107798391 @default.
• W4321354447 cites W2109435900 @default.
• W4321354447 cites W2114613490 @default.
• W4321354447 cites W2123311421 @default.
• W4321354447 cites W2127819913 @default.
• W4321354447 cites W2134354395 @default.
• W4321354447 cites W2140606211 @default.
• W4321354447 cites W2153518194 @default.
• W4321354447 cites W2158329357 @default.
• W4321354447 cites W2162950935 @default.
• W4321354447 cites W2166996282 @default.
• W4321354447 cites W2216257364 @default.
• W4321354447 cites W2321406476 @default.
• W4321354447 cites W2335196723 @default.
• W4321354447 cites W2528662465 @default.
• W4321354447 cites W2590200842 @default.
• W4321354447 cites W2594193766 @default.
• W4321354447 cites W2799919475 @default.
• W4321354447 cites W2894533856 @default.
• W4321354447 cites W2921960509 @default.
• W4321354447 cites W2969797731 @default.
• W4321354447 cites W2996593546 @default.
• W4321354447 cites W3020075787 @default.
• W4321354447 cites W3083549033 @default.
• W4321354447 cites W3112946999 @default.
• W4321354447 cites W3123684028 @default.
• W4321354447 cites W4211174138 @default.
• W4321354447 cites W4220746180 @default.
• W4321354447 cites W4288046315 @default.
• W4321354447 cites W4292528167 @default.
• W4321354447 doi "https://doi.org/10.1016/j.schres.2023.02.020" @default.
• W4321354447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36805834" @default.
• W4321354447 hasPublicationYear "2023" @default.
• W4321354447 type Work @default.
• W4321354447 citedByCount "2" @default.
• W4321354447 countsByYear W43213544472023 @default.
• W4321354447 crossrefType "journal-article" @default.
• W4321354447 hasAuthorship W4321354447A5001428893 @default.
• W4321354447 hasAuthorship W4321354447A5003741699 @default.
• W4321354447 hasAuthorship W4321354447A5008181440 @default.
• W4321354447 hasAuthorship W4321354447A5025427272 @default.
• W4321354447 hasAuthorship W4321354447A5031106277 @default.
• W4321354447 hasAuthorship W4321354447A5046823287 @default.
• W4321354447 hasAuthorship W4321354447A5067824967 @default.
• W4321354447 hasAuthorship W4321354447A5073521992 @default.
• W4321354447 hasAuthorship W4321354447A5081859146 @default.
• W4321354447 hasAuthorship W4321354447A5088810181 @default.
• W4321354447 hasConcept C118552586 @default.
• W4321354447 hasConcept C126322002 @default.
• W4321354447 hasConcept C142724271 @default.
• W4321354447 hasConcept C168563851 @default.
• W4321354447 hasConcept C197934379 @default.
• W4321354447 hasConcept C204787440 @default.
• W4321354447 hasConcept C27081682 @default.
• W4321354447 hasConcept C2776036978 @default.
• W4321354447 hasConcept C2776412080 @default.
• W4321354447 hasConcept C2779727114 @default.
• W4321354447 hasConcept C2780057945 @default.
• W4321354447 hasConcept C2780135775 @default.
• W4321354447 hasConcept C2780494398 @default.
• W4321354447 hasConcept C2780616385 @default.
• W4321354447 hasConcept C2780640218 @default.
• W4321354447 hasConcept C535046627 @default.
• W4321354447 hasConcept C71924100 @default.
• W4321354447 hasConceptScore W4321354447C118552586 @default.
• W4321354447 hasConceptScore W4321354447C126322002 @default.
• W4321354447 hasConceptScore W4321354447C142724271 @default.
• W4321354447 hasConceptScore W4321354447C168563851 @default.
• W4321354447 hasConceptScore W4321354447C197934379 @default.
• W4321354447 hasConceptScore W4321354447C204787440 @default.

• next