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• W4321354489 endingPage "156159" @default.
• W4321354489 startingPage "156159" @default.
• W4321354489 abstract "Interleukin (IL)-4 and IL-13 are related cytokines with well-known specific roles in type 2 immune response. However, their effects on neutrophils are not completely understood. For this, we studied human primary neutrophil responses to IL-4 and IL-13. Neutrophils are dose-dependently responsive to both IL-4 and IL-13 as indicated by signal transducer and activator of transcription 6 (STAT6) phosphorylation upon stimulation, with IL-4 being more potent inducer of STAT6. IL-4-, IL-13- and Interferon (IFN)-γ-stimulated gene expression in highly purified human neutrophils induced both overlapping and unique gene expression in highly purified human neutrophils. IL-4 and IL-13 specifically regulate several immune-related genes, including IL-10, tumor necrosis factor (TNF) and leukemia inhibitory factor (LIF), while type1 immune response-related IFN-γ induced gene expression related for example, to intracellular infections. In analysis of neutrophil metabolic responses, oxygen independent glycolysis was specifically regulated by IL-4, but not by IL-13 or IFN-γ, suggesting specific role for type I IL-4 receptor in this process. Our results provide a comprehensive analysis of IL-4, IL-13 and IFN-γ -induced gene expression in neutrophils while also addressing cytokine-mediated metabolic changes in neutrophils." @default.
• W4321354489 created "2023-02-20" @default.
• W4321354489 creator A5006053903 @default.
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• W4321354489 creator A5065394360 @default.
• W4321354489 creator A5090914300 @default.
• W4321354489 creator A5091111944 @default.
• W4321354489 date "2023-04-01" @default.
• W4321354489 modified "2023-10-18" @default.
• W4321354489 title "IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils" @default.
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• W4321354489 doi "https://doi.org/10.1016/j.cyto.2023.156159" @default.
• W4321354489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36809715" @default.
• W4321354489 hasPublicationYear "2023" @default.
• W4321354489 type Work @default.

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