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• W4321365743 abstract "Reactive oxygen species (ROS)-based therapeutic strategies play an important role in cancer treatment. However, in situ, real-time and quantitative analysis of intracellular ROS in cancer treatment for drug screening is still a challenge. Herein we report one selective hydrogen peroxide (H2 O2 ) electrochemical nanosensor, which is prepared by electrodeposition of Prussian blue (PB) and polyethylenedioxythiophene (PEDOT) onto carbon fiber nanoelectrode. With the nanosensor, we find that the level of intracellular H2 O2 increases with NADH treatment and that increase is dose-dependent to the concentration of NADH. High-dose of NADH (above 10 mM) can induce cell death and intratumoral injection of NADH is validated for inhibiting tumor growth in mice. This study highlights the potential of electrochemical nanosensor for tracking and understanding the role of H2 O2 in screening new anticancer drug." @default.
• W4321365743 created "2023-02-21" @default.
• W4321365743 creator A5000097812 @default.
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• W4321365743 date "2023-03-08" @default.
• W4321365743 modified "2023-10-02" @default.
• W4321365743 title "An Electrochemical Nanosensor for Monitoring the Dynamics of Intracellular H₂O₂ Upon NADH Treatment" @default.
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• W4321365743 doi "https://doi.org/10.1002/anie.202300083" @default.
• W4321365743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36807970" @default.
• W4321365743 hasPublicationYear "2023" @default.
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