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- W4321366903 abstract "The yeast thiamin pyrimidine synthase THI5p catalyzes one of the most complex organic rearrangements found in primary metabolism. In this reaction, the active site His66 and PLP are converted to thiamin pyrimidine in the presence of Fe(II) and oxygen. The enzyme is a single-turnover enzyme. Here, we report the identification of an oxidatively dearomatized PLP intermediate. We utilize oxygen labeling studies, chemical-rescue-based partial reconstitution experiments, and chemical model studies to support this identification. In addition, we also identify and characterize three shunt products derived from the oxidatively dearomatized PLP." @default.
- W4321366903 created "2023-02-21" @default.
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- W4321366903 date "2023-02-20" @default.
- W4321366903 modified "2023-10-01" @default.
- W4321366903 title "Oxidative Dearomatization of PLP in Thiamin Pyrimidine Biosynthesis in <i>Candida albicans</i>" @default.
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- W4321366903 doi "https://doi.org/10.1021/jacs.2c08560" @default.
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