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• W4321368145 endingPage "105734" @default.
• W4321368145 startingPage "105734" @default.
• W4321368145 abstract "Different methods and several physical models exist to study cell viscoelasticity with the atomic force microscope (AFM). In search of a robust mechanical classification of cells through AFM, in this work, viscoelastic parameters of the cancer cell lines MDA-MB-231, DU-145, and MG-63 are obtained using two methodologies; through force-distance and force-relaxation curves. Four mechanical models were applied to fit the curves. The results show that both methodologies agree qualitatively on the parameters that quantify elasticity but disagree on the parameters that account for energy dissipation. The Fractional Zener (FZ) model represents well the information given by the Solid Linear Standard and Generalized Maxwell models. The Fractional Kelvin (FK) model concentrates the viscoelastic information mainly in two parameters, which could be an advantage over the other models. Therefore, the FZ and FK models are proposed as the basis for the classification of cancer cells. However, more research using these models is needed to obtain a broader view of the meaning of each parameter and to be able to establish a relationship between the parameters and the cellular components." @default.
• W4321368145 created "2023-02-21" @default.
• W4321368145 creator A5006579786 @default.
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• W4321368145 date "2023-04-01" @default.
• W4321368145 modified "2023-10-18" @default.
• W4321368145 title "Methodologies and models for measuring viscoelastic properties of cancer cells: Towards a universal classification" @default.
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• W4321368145 doi "https://doi.org/10.1016/j.jmbbm.2023.105734" @default.
• W4321368145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36848744" @default.
• W4321368145 hasPublicationYear "2023" @default.
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