Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321370143> ?p ?o ?g. }
- W4321370143 endingPage "2394" @default.
- W4321370143 startingPage "2381" @default.
- W4321370143 abstract "Abstract Osteoarthritis (OA) is a complex joint disease characterized by persistent pain. Unfortunately, current pharmacological therapies are unsatisfactory and characterized by side effects, reason why new strategies are needed. We tested the efficacy of different classes of compounds, ellagitannins and olean‐type triterpenoids, contained in Anogeissus leiocarpus extract (Combretaceae family) in comparison to ellagitannins of Castanea sativa extract in a rat model of osteoarthritis induced by the intra‐articular injection of sodium monoiodoacetate (MIA). The decoction of stem bark of A. leiocarpus AL‐DEC‐TOT (300 mg/kg; 4.8% triterpenoids; 11.0% tannins), the butanol extract AL‐BuOH‐EXT (120 mg/kg; triterpenoids 20.9%; tannins 6.4%) and its correlated aqueous residue AL‐Res‐H 2 O (300 mg/kg; triterpenoids 0.7%; tannins 8.7%) and the decoction of C. sativa , CS‐DEC‐TOT, (240 mg/kg; triterpenoids 0.65%; tannins 10.8%) were orally administered for two weeks starting from the day of the damage. Behavioural tests highlighted that all stem bark extracts of A. leiocarpus counteracted hypersensitivity development, reduced spontaneous pain, and improved motor skills. Histologically, AL‐DEC‐TOT, AL‐BuOH‐EXT and AL‐Res‐H 2 O were effective in preventing joint alterations. In conclusion, all the extracts were effective demonstrating that both olean‐type triterpenoid and ellagitannin fractions have anti‐hypersensitivity and restorative properties running the stem bark extracts of A. leiocarpus as a candidate in the treatment of OA." @default.
- W4321370143 created "2023-02-21" @default.
- W4321370143 creator A5017221256 @default.
- W4321370143 creator A5035325188 @default.
- W4321370143 creator A5049261961 @default.
- W4321370143 creator A5056328426 @default.
- W4321370143 creator A5060512635 @default.
- W4321370143 creator A5065819291 @default.
- W4321370143 creator A5075134609 @default.
- W4321370143 creator A5087210343 @default.
- W4321370143 creator A5087547468 @default.
- W4321370143 creator A5091595453 @default.
- W4321370143 date "2023-02-20" @default.
- W4321370143 modified "2023-10-17" @default.
- W4321370143 title "Ellagitannins and triterpenoids extracts of <i>Anogeissus leiocarpus</i> stem bark extracts: Protective effects against osteoarthritis" @default.
- W4321370143 cites W1858465734 @default.
- W4321370143 cites W1859919406 @default.
- W4321370143 cites W1888470382 @default.
- W4321370143 cites W1907909084 @default.
- W4321370143 cites W1981022368 @default.
- W4321370143 cites W1983229627 @default.
- W4321370143 cites W1983793066 @default.
- W4321370143 cites W1984981145 @default.
- W4321370143 cites W1985608961 @default.
- W4321370143 cites W1986623187 @default.
- W4321370143 cites W1989111541 @default.
- W4321370143 cites W1993948165 @default.
- W4321370143 cites W1995654099 @default.
- W4321370143 cites W1998024620 @default.
- W4321370143 cites W2001762931 @default.
- W4321370143 cites W2005539095 @default.
- W4321370143 cites W2009339344 @default.
- W4321370143 cites W2019972898 @default.
- W4321370143 cites W2022219238 @default.
- W4321370143 cites W2024212561 @default.
- W4321370143 cites W2026123588 @default.
- W4321370143 cites W2028212402 @default.
- W4321370143 cites W2028469883 @default.
- W4321370143 cites W2043338780 @default.
- W4321370143 cites W2055757006 @default.
- W4321370143 cites W2061214727 @default.
- W4321370143 cites W2066322182 @default.
- W4321370143 cites W2068854110 @default.
- W4321370143 cites W2068879317 @default.
- W4321370143 cites W2078828283 @default.
- W4321370143 cites W2086385875 @default.
- W4321370143 cites W2088311820 @default.
- W4321370143 cites W2090157329 @default.
- W4321370143 cites W2112914937 @default.
- W4321370143 cites W2115601182 @default.
- W4321370143 cites W2120342328 @default.
- W4321370143 cites W2124032632 @default.
- W4321370143 cites W2133075927 @default.
- W4321370143 cites W2139736838 @default.
- W4321370143 cites W2143221646 @default.
- W4321370143 cites W2253282997 @default.
- W4321370143 cites W2319173087 @default.
- W4321370143 cites W2348185624 @default.
- W4321370143 cites W2409825930 @default.
- W4321370143 cites W2469652392 @default.
- W4321370143 cites W2471351690 @default.
- W4321370143 cites W2520202539 @default.
- W4321370143 cites W2520320911 @default.
- W4321370143 cites W2757398440 @default.
- W4321370143 cites W2763150831 @default.
- W4321370143 cites W2803055284 @default.
- W4321370143 cites W2804767456 @default.
- W4321370143 cites W2886598219 @default.
- W4321370143 cites W2908861482 @default.
- W4321370143 cites W2916067921 @default.
- W4321370143 cites W2937687149 @default.
- W4321370143 cites W2940625028 @default.
- W4321370143 cites W3009853031 @default.
- W4321370143 cites W3029947261 @default.
- W4321370143 cites W3034757018 @default.
- W4321370143 cites W4200250010 @default.
- W4321370143 cites W4211256917 @default.
- W4321370143 doi "https://doi.org/10.1002/ptr.7760" @default.
- W4321370143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36806301" @default.
- W4321370143 hasPublicationYear "2023" @default.
- W4321370143 type Work @default.
- W4321370143 citedByCount "0" @default.
- W4321370143 crossrefType "journal-article" @default.
- W4321370143 hasAuthorship W4321370143A5017221256 @default.
- W4321370143 hasAuthorship W4321370143A5035325188 @default.
- W4321370143 hasAuthorship W4321370143A5049261961 @default.
- W4321370143 hasAuthorship W4321370143A5056328426 @default.
- W4321370143 hasAuthorship W4321370143A5060512635 @default.
- W4321370143 hasAuthorship W4321370143A5065819291 @default.
- W4321370143 hasAuthorship W4321370143A5075134609 @default.
- W4321370143 hasAuthorship W4321370143A5087210343 @default.
- W4321370143 hasAuthorship W4321370143A5087547468 @default.
- W4321370143 hasAuthorship W4321370143A5091595453 @default.
- W4321370143 hasConcept C107585567 @default.
- W4321370143 hasConcept C133446333 @default.
- W4321370143 hasConcept C142724271 @default.
- W4321370143 hasConcept C185592680 @default.
- W4321370143 hasConcept C18903297 @default.