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- W4321373797 endingPage "651" @default.
- W4321373797 startingPage "651" @default.
- W4321373797 abstract "Parkinson's disease (PD) is a neurodegenerative disorder that has been associated with mitochondrial dysfunction, oxidative stress, and defects in mitophagy as well as α-synuclein-positive inclusions, termed Lewy bodies (LBs), which are a common pathological hallmark in PD. Mitophagy is a process that maintains cellular health by eliminating dysfunctional mitochondria, and it is triggered by ubiquitination of mitochondrial-associated proteins-e.g., through the PINK1/Parkin pathway-which results in engulfment by the autophagosome and degradation in lysosomes. Deubiquitinating enzymes (DUBs) can regulate this process at several levels by deubiquitinating mitochondrial substrates and other targets in the mitophagic pathway, such as Parkin. Moreover, DUBs can affect α-synuclein aggregation through regulation of degradative pathways, deubiquitination of α-synuclein itself, and/or via co-localization with α-synuclein in inclusions. DUBs with a known association to PD are described in this paper, along with their function. Of interest, DUBs could be useful as novel therapeutic targets against PD through regulation of PD-associated defects." @default.
- W4321373797 created "2023-02-21" @default.
- W4321373797 creator A5034946522 @default.
- W4321373797 creator A5035519174 @default.
- W4321373797 creator A5080628229 @default.
- W4321373797 date "2023-02-17" @default.
- W4321373797 modified "2023-10-01" @default.
- W4321373797 title "Role of Deubiquitinases in Parkinson’s Disease—Therapeutic Perspectives" @default.
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