FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321373869> ?p ?o ?g. }

• W4321373869 endingPage "4203" @default.
• W4321373869 startingPage "4203" @default.
• W4321373869 abstract "Short-chain fatty acids (SCFAs) play a pivotal role in regulating the proliferation and development of bovine rumen epithelial cells (BRECs). G protein-coupled receptor 41 (GPR41) is involved in the signal transduction in BRECs as a receptor for SCFAs. Nevertheless, the impact of GPR41 on the proliferation of BRECs has not been reported. The results of this research showed that the knockdown of GPR41 (GRP41KD) decreased BRECs proliferation compared with the wild-type BRECs (WT) (p < 0.001). The RNA sequencing (RNA-seq) analysis showed that the gene expression profiles differed between WT and GPR41KD BRECs, with the major differential genes enriched in phosphatidylinositol 3-kinase (PIK3) signaling, cell cycle, and amino acid transport pathways (p < 0.05). The transcriptome data were further validated by Western blot and qRT-PCR. It was evident that the GPR41KD BRECs downregulated the level of the PIK3-Protein kinase B (AKT)-mammalian target of the rapamycin (mTOR) signaling pathway core genes, such as PIK3, AKT, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and mTOR contrasted with the WT cells (p < 0.01). Furthermore, the GPR41KD BRECs downregulated the level of Cyclin D2 p < 0.001) and Cyclin E2 (p < 0.05) compared with the WT cells. Therefore, it was proposed that GPR41 may affect the proliferation of BRECs by mediating the PIK3-AKT-mTOR signaling pathway." @default.
• W4321373869 created "2023-02-21" @default.
• W4321373869 creator A5004019041 @default.
• W4321373869 creator A5010987050 @default.
• W4321373869 creator A5028287447 @default.
• W4321373869 creator A5030229030 @default.
• W4321373869 creator A5070528488 @default.
• W4321373869 date "2023-02-20" @default.
• W4321373869 modified "2023-10-16" @default.
• W4321373869 title "GPR41 Regulates the Proliferation of BRECs via the PIK3-AKT-mTOR Pathway" @default.
• W4321373869 cites W1573621404 @default.
• W4321373869 cites W1964173392 @default.
• W4321373869 cites W1965766554 @default.
• W4321373869 cites W1970515701 @default.
• W4321373869 cites W1973398468 @default.
• W4321373869 cites W1974842064 @default.
• W4321373869 cites W1981711832 @default.
• W4321373869 cites W1982789056 @default.
• W4321373869 cites W1984621921 @default.
• W4321373869 cites W1991199800 @default.
• W4321373869 cites W2000117132 @default.
• W4321373869 cites W2017882961 @default.
• W4321373869 cites W2057370954 @default.
• W4321373869 cites W2077478539 @default.
• W4321373869 cites W2097486000 @default.
• W4321373869 cites W2112686792 @default.
• W4321373869 cites W2122062629 @default.
• W4321373869 cites W2133446206 @default.
• W4321373869 cites W2134138119 @default.
• W4321373869 cites W2138792241 @default.
• W4321373869 cites W2157497892 @default.
• W4321373869 cites W2309809352 @default.
• W4321373869 cites W2327754435 @default.
• W4321373869 cites W2335874850 @default.
• W4321373869 cites W2508164543 @default.
• W4321373869 cites W2549613338 @default.
• W4321373869 cites W2590624416 @default.
• W4321373869 cites W2742368813 @default.
• W4321373869 cites W2753469459 @default.
• W4321373869 cites W2769860363 @default.
• W4321373869 cites W2795449839 @default.
• W4321373869 cites W2900878259 @default.
• W4321373869 cites W2903976869 @default.
• W4321373869 cites W2906491377 @default.
• W4321373869 cites W2915580372 @default.
• W4321373869 cites W2963367647 @default.
• W4321373869 cites W2963766370 @default.
• W4321373869 cites W2968979230 @default.
• W4321373869 cites W2970684207 @default.
• W4321373869 cites W2975860835 @default.
• W4321373869 cites W2982203283 @default.
• W4321373869 cites W2997591351 @default.
• W4321373869 cites W3008801636 @default.
• W4321373869 cites W3015437380 @default.
• W4321373869 cites W3094632930 @default.
• W4321373869 cites W3164718582 @default.
• W4321373869 cites W3201334441 @default.
• W4321373869 cites W3206725343 @default.
• W4321373869 cites W4220663765 @default.
• W4321373869 cites W4226050921 @default.
• W4321373869 cites W4283394180 @default.
• W4321373869 cites W4291149404 @default.
• W4321373869 doi "https://doi.org/10.3390/ijms24044203" @default.
• W4321373869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36835615" @default.
• W4321373869 hasPublicationYear "2023" @default.
• W4321373869 type Work @default.
• W4321373869 citedByCount "1" @default.
• W4321373869 countsByYear W43213738692023 @default.
• W4321373869 crossrefType "journal-article" @default.
• W4321373869 hasAuthorship W4321373869A5004019041 @default.
• W4321373869 hasAuthorship W4321373869A5010987050 @default.
• W4321373869 hasAuthorship W4321373869A5028287447 @default.
• W4321373869 hasAuthorship W4321373869A5030229030 @default.
• W4321373869 hasAuthorship W4321373869A5070528488 @default.
• W4321373869 hasBestOaLocation W43213738691 @default.
• W4321373869 hasConcept C153911025 @default.
• W4321373869 hasConcept C185592680 @default.
• W4321373869 hasConcept C55493867 @default.
• W4321373869 hasConcept C62478195 @default.
• W4321373869 hasConcept C75217442 @default.
• W4321373869 hasConcept C86554907 @default.
• W4321373869 hasConcept C86803240 @default.
• W4321373869 hasConceptScore W4321373869C153911025 @default.
• W4321373869 hasConceptScore W4321373869C185592680 @default.
• W4321373869 hasConceptScore W4321373869C55493867 @default.
• W4321373869 hasConceptScore W4321373869C62478195 @default.
• W4321373869 hasConceptScore W4321373869C75217442 @default.
• W4321373869 hasConceptScore W4321373869C86554907 @default.
• W4321373869 hasConceptScore W4321373869C86803240 @default.
• W4321373869 hasIssue "4" @default.
• W4321373869 hasLocation W43213738691 @default.
• W4321373869 hasLocation W43213738692 @default.
• W4321373869 hasLocation W43213738693 @default.
• W4321373869 hasOpenAccess W4321373869 @default.
• W4321373869 hasPrimaryLocation W43213738691 @default.
• W4321373869 hasRelatedWork W2360303253 @default.
• W4321373869 hasRelatedWork W2376211306 @default.
• W4321373869 hasRelatedWork W2376913815 @default.

• next