Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321374240> ?p ?o ?g. }
- W4321374240 endingPage "4133" @default.
- W4321374240 startingPage "4133" @default.
- W4321374240 abstract "The infections caused by the HSV-1 virus induce lesions on the lips, mouth, face, and eye. In this study, an ethosome gel loaded with dimethyl fumarate was investigated as a possible approach to treat HSV-1 infections. A formulative study was conducted, evaluating the effect of drug concentration on size distribution and dimensional stability of ethosomes by photon correlation spectroscopy. Ethosome morphology was investigated by cryogenic transmission electron microscopy, while the interaction between dimethyl fumarate and vesicles, and the drug entrapment capacity were respectively evaluated by FTIR and HPLC. To favor the topical application of ethosomes on mucosa and skin, different semisolid forms, based on xanthan gum or poloxamer 407, were designed and compared for spreadability and leakage. Dimethyl fumarate release and diffusion kinetics were evaluated in vitro by Franz cells. The antiviral activity against HSV-1 was tested by plaque reduction assay in Vero and HRPE monolayer cells, while skin irritation effect was evaluated by patch test on 20 healthy volunteers. The lower drug concentration was selected, resulting in smaller and longer stable vesicles, mainly characterized by a multilamellar organization. Dimethyl fumarate entrapment in ethosome was 91% w/w, suggesting an almost total recovery of the drug in the lipid phase. Xanthan gum 0.5%, selected to thicken the ethosome dispersion, allowed to control drug release and diffusion. The antiviral effect of dimethyl fumarate loaded in ethosome gel was demonstrated by a reduction in viral growth both 1 h and 4 h post-infection. Moreover, the patch test demonstrated the safety of the ethosomal gel applied on the skin." @default.
- W4321374240 created "2023-02-21" @default.
- W4321374240 creator A5004711394 @default.
- W4321374240 creator A5017653359 @default.
- W4321374240 creator A5032530413 @default.
- W4321374240 creator A5042369783 @default.
- W4321374240 creator A5049659836 @default.
- W4321374240 creator A5051955597 @default.
- W4321374240 creator A5069510824 @default.
- W4321374240 creator A5083111559 @default.
- W4321374240 creator A5089561226 @default.
- W4321374240 creator A5089645804 @default.
- W4321374240 date "2023-02-18" @default.
- W4321374240 modified "2023-10-01" @default.
- W4321374240 title "Ethosomal Gel for Topical Administration of Dimethyl Fumarate in the Treatment of HSV-1 Infections" @default.
- W4321374240 cites W17770176 @default.
- W4321374240 cites W1950566269 @default.
- W4321374240 cites W1969604041 @default.
- W4321374240 cites W1972799272 @default.
- W4321374240 cites W1974005309 @default.
- W4321374240 cites W1978308399 @default.
- W4321374240 cites W2004123015 @default.
- W4321374240 cites W2014144868 @default.
- W4321374240 cites W2018867886 @default.
- W4321374240 cites W2019274109 @default.
- W4321374240 cites W2030968061 @default.
- W4321374240 cites W2032276237 @default.
- W4321374240 cites W2048836307 @default.
- W4321374240 cites W2061112966 @default.
- W4321374240 cites W2061292693 @default.
- W4321374240 cites W2066675802 @default.
- W4321374240 cites W2082393473 @default.
- W4321374240 cites W2086483875 @default.
- W4321374240 cites W2127884387 @default.
- W4321374240 cites W2127921493 @default.
- W4321374240 cites W2164554364 @default.
- W4321374240 cites W2327732159 @default.
- W4321374240 cites W2418542665 @default.
- W4321374240 cites W2545660909 @default.
- W4321374240 cites W2606696372 @default.
- W4321374240 cites W2732001526 @default.
- W4321374240 cites W2766346344 @default.
- W4321374240 cites W2790244351 @default.
- W4321374240 cites W2806042548 @default.
- W4321374240 cites W2807808853 @default.
- W4321374240 cites W2883953396 @default.
- W4321374240 cites W2890207358 @default.
- W4321374240 cites W2890854556 @default.
- W4321374240 cites W2907787259 @default.
- W4321374240 cites W2964177104 @default.
- W4321374240 cites W2974855993 @default.
- W4321374240 cites W2976219811 @default.
- W4321374240 cites W2990802025 @default.
- W4321374240 cites W2992677274 @default.
- W4321374240 cites W2996022457 @default.
- W4321374240 cites W3010250953 @default.
- W4321374240 cites W3016534326 @default.
- W4321374240 cites W3033148019 @default.
- W4321374240 cites W3047305009 @default.
- W4321374240 cites W3091285461 @default.
- W4321374240 cites W3097756132 @default.
- W4321374240 cites W3105001903 @default.
- W4321374240 cites W3116265355 @default.
- W4321374240 cites W3126070213 @default.
- W4321374240 cites W3143841313 @default.
- W4321374240 cites W3161032182 @default.
- W4321374240 cites W3163227665 @default.
- W4321374240 cites W3184760860 @default.
- W4321374240 cites W3196241230 @default.
- W4321374240 cites W4200391398 @default.
- W4321374240 cites W4206115880 @default.
- W4321374240 cites W4232589610 @default.
- W4321374240 cites W4280632558 @default.
- W4321374240 cites W4283779681 @default.
- W4321374240 cites W4290600789 @default.
- W4321374240 cites W4311093779 @default.
- W4321374240 cites W4311717369 @default.
- W4321374240 cites W4311791616 @default.
- W4321374240 cites W4313596732 @default.
- W4321374240 cites W54782832 @default.
- W4321374240 doi "https://doi.org/10.3390/ijms24044133" @default.
- W4321374240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36835541" @default.
- W4321374240 hasPublicationYear "2023" @default.
- W4321374240 type Work @default.
- W4321374240 citedByCount "4" @default.
- W4321374240 countsByYear W43213742402023 @default.
- W4321374240 crossrefType "journal-article" @default.
- W4321374240 hasAuthorship W4321374240A5004711394 @default.
- W4321374240 hasAuthorship W4321374240A5017653359 @default.
- W4321374240 hasAuthorship W4321374240A5032530413 @default.
- W4321374240 hasAuthorship W4321374240A5042369783 @default.
- W4321374240 hasAuthorship W4321374240A5049659836 @default.
- W4321374240 hasAuthorship W4321374240A5051955597 @default.
- W4321374240 hasAuthorship W4321374240A5069510824 @default.
- W4321374240 hasAuthorship W4321374240A5083111559 @default.
- W4321374240 hasAuthorship W4321374240A5089561226 @default.
- W4321374240 hasAuthorship W4321374240A5089645804 @default.
- W4321374240 hasBestOaLocation W43213742401 @default.