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- W4321376278 endingPage "1950" @default.
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- W4321376278 abstract "Muscle atrophy, also known as muscle wasting, is the thinning of muscle mass due to muscle disuse, aging, or diseases such as cancer or neurological problems. Muscle atrophy is closely related to the quality of life and has high morbidity and mortality. However, therapeutic options for muscle atrophy are limited, so studies to develop therapeutic agents for muscle loss are always required. For this study, we investigated how orally administered specific collagen peptides (CP) affect muscle atrophy and elucidated its molecular mechanism using an in vivo model. We treated mice with dexamethasone (DEX) to induce a muscular atrophy phenotype and then administered CP (0.25 and 0.5 g/kg) for four weeks. In a microcomputed tomography analysis, CP (0.5 g/kg) intake significantly increased the volume of calf muscles in mice with DEX-induced muscle atrophy. In addition, the administration of CP (0.25 and 0.5 g/kg) restored the weight of the gluteus maximus and the fiber cross-sectional area (CSA) of the pectoralis major and calf muscles, which were reduced by DEX. CP significantly inhibited the mRNA expression of myostatin and the phosphorylation of Smad2, but it did not affect TGF-β, BDNF, or FNDC5 gene expression. In addition, AKT/mTOR, a central pathway for muscle protein synthesis and related to myostatin signaling, was enhanced in the groups that were administered CP. Finally, CP decreased serum albumin levels and increased TNF-α gene expression. Collectively, our in vivo results demonstrate that CP can alleviate muscle wasting through a multitude of mechanisms. Therefore, we propose CP as a supplement or treatment to prevent muscle atrophy." @default.
- W4321376278 created "2023-02-21" @default.
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- W4321376278 date "2023-02-18" @default.
- W4321376278 modified "2023-09-26" @default.
- W4321376278 title "The Preventive Effect of Specific Collagen Peptides against Dexamethasone-Induced Muscle Atrophy in Mice" @default.
- W4321376278 cites W1572327103 @default.
- W4321376278 cites W1760390524 @default.
- W4321376278 cites W1867779249 @default.
- W4321376278 cites W1888932721 @default.
- W4321376278 cites W1925594358 @default.
- W4321376278 cites W1971857747 @default.
- W4321376278 cites W1977370866 @default.
- W4321376278 cites W1986031970 @default.
- W4321376278 cites W1988247104 @default.
- W4321376278 cites W1993497859 @default.
- W4321376278 cites W1993894887 @default.
- W4321376278 cites W2000066959 @default.
- W4321376278 cites W2006000330 @default.
- W4321376278 cites W2007917983 @default.
- W4321376278 cites W2033797333 @default.
- W4321376278 cites W2033924360 @default.
- W4321376278 cites W2039272248 @default.
- W4321376278 cites W2041787131 @default.
- W4321376278 cites W2045851871 @default.
- W4321376278 cites W2050967224 @default.
- W4321376278 cites W2051652691 @default.
- W4321376278 cites W2053079324 @default.
- W4321376278 cites W2053870372 @default.
- W4321376278 cites W2064760978 @default.
- W4321376278 cites W2065056367 @default.
- W4321376278 cites W2076975132 @default.
- W4321376278 cites W2081934744 @default.
- W4321376278 cites W2088689184 @default.
- W4321376278 cites W2109356273 @default.
- W4321376278 cites W2115523499 @default.
- W4321376278 cites W2149993139 @default.
- W4321376278 cites W2151258296 @default.
- W4321376278 cites W2159802435 @default.
- W4321376278 cites W2162063376 @default.
- W4321376278 cites W2164641915 @default.
- W4321376278 cites W2166601621 @default.
- W4321376278 cites W2166877291 @default.
- W4321376278 cites W2167339563 @default.
- W4321376278 cites W2168293740 @default.
- W4321376278 cites W2273382762 @default.
- W4321376278 cites W2343952365 @default.
- W4321376278 cites W2344822791 @default.
- W4321376278 cites W2510434214 @default.
- W4321376278 cites W2531143283 @default.
- W4321376278 cites W2538013277 @default.
- W4321376278 cites W2734293889 @default.
- W4321376278 cites W2735319535 @default.
- W4321376278 cites W2765141291 @default.
- W4321376278 cites W2769276755 @default.
- W4321376278 cites W2771366053 @default.
- W4321376278 cites W2788264780 @default.
- W4321376278 cites W2792102363 @default.
- W4321376278 cites W2807866428 @default.
- W4321376278 cites W2883614888 @default.
- W4321376278 cites W2905955359 @default.
- W4321376278 cites W2911244367 @default.
- W4321376278 cites W2937601882 @default.
- W4321376278 cites W2938839216 @default.
- W4321376278 cites W2945895936 @default.
- W4321376278 cites W2959540491 @default.
- W4321376278 cites W2963585097 @default.
- W4321376278 cites W2984841306 @default.
- W4321376278 cites W3013080227 @default.
- W4321376278 cites W3084210108 @default.
- W4321376278 cites W3090494367 @default.
- W4321376278 cites W3095022721 @default.
- W4321376278 cites W3110979931 @default.
- W4321376278 cites W3121032204 @default.
- W4321376278 cites W3134534336 @default.
- W4321376278 cites W3158509792 @default.
- W4321376278 cites W3184414788 @default.
- W4321376278 cites W3186065666 @default.
- W4321376278 cites W3198975334 @default.
- W4321376278 cites W3200254991 @default.
- W4321376278 cites W32359538 @default.
- W4321376278 cites W4212936781 @default.
- W4321376278 cites W4223623470 @default.
- W4321376278 cites W2905883881 @default.
- W4321376278 cites W3106683834 @default.