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• W4321377013 endingPage "1925" @default.
• W4321377013 startingPage "1925" @default.
• W4321377013 abstract "New antioxidant agents are urgently required to combat oxidative stress, which is linked to the emergence of serious diseases. In an effort to discover potent antioxidant agents, a novel series of 2-thiouracil-5-sulfonamides (4–9) were designed and synthesized. In line with this approach, our target new compounds were prepared from methyl ketone derivative 3, which was used as a blocking unit for further synthesis of a novel series of chalcone derivatives 4a–d, thiosemicarbazone derivatives 5a–d, pyridine derivatives 6a–d and 7a–d, bromo acetyl derivative 8, and thiazole derivatives 9a–d. All compounds were evaluated as antioxidants against 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2), lipid peroxidation, and 15-lipoxygenase (15-LOX) inhibition activity. Compounds 5c, 6d, 7d, 9b, 9c, and 9d demonstrated significant RSA in all three techniques in comparison with ascorbic acid and 15-LOX inhibitory effectiveness using quercetin as a standard. Molecular docking of compound 9b endorsed its proper binding at the active site pocket of the human 15-LOX which explains its potent antioxidant activity in comparison with standard ascorbic acid." @default.
• W4321377013 created "2023-02-21" @default.
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• W4321377013 date "2023-02-17" @default.
• W4321377013 modified "2023-10-14" @default.
• W4321377013 title "Novel 2-Thiouracil-5-Sulfonamide Derivatives: Design, Synthesis, Molecular Docking, and Biological Evaluation as Antioxidants with 15-LOX Inhibition" @default.
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• W4321377013 doi "https://doi.org/10.3390/molecules28041925" @default.
• W4321377013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36838913" @default.
• W4321377013 hasPublicationYear "2023" @default.
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