FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321378656> ?p ?o ?g. }

• W4321378656 endingPage "35" @default.
• W4321378656 startingPage "26" @default.
• W4321378656 abstract "Secreted phosphoprotein 1 (SPP1) functions in several physiological processes. The role of SPP1 expression in the prognosis and tumor immunity of hepatocellular carcinoma (HCC) is unknown. The aim of this study was to investigate the expression pattern of SPP1 in HCC and its correlation with prognosis and tumor immunity. Clinical and gene expression data of The Cancer Genome Atlas-liver hepatocellular carcinoma (LIHC) cohort and 11 other HCC datasets were collected. The Kaplan–Meier method and Cox regression analysis were used to analyze the prognostic value of SPP1. The DESeq2 package in R was used to analyze SPP1-related genes. Gene Ontology analysis and gene set enrichment analysis were used to determine the biological function of SPP1 in HCC. The single sample Gene Set Enrichment Analysis (ssGSEA) method was used to analyze the immune infiltrates of HCC. Illumina human methylation 450 data and level 3 HTSeq-FPKM data from The Cancer Genome Atlas-LIHC were used to analyze the effects of DNA methylation level on SPP1 expression. SPP1 was overexpressed in HCC and correlated with T stage, histological grade, adjacent hepatic tissue inflammation, and vascular invasion in HCC. The analysis of survival rates indicated that high SPP1 levels were associated with poor overall survival in HCC. Functional analysis showed that SPP1 is related to tumor immunity, especially macrophage infiltration. Aberrant demethylation of the promoter region is one of the mechanisms underlying the increase of SPP1 in HCC. Our results indicate that SPP1 is an independent prognostic factor for HCC and is correlated with the clinical features and macrophage infiltration in HCC." @default.
• W4321378656 created "2023-02-21" @default.
• W4321378656 creator A5003591674 @default.
• W4321378656 creator A5018892767 @default.
• W4321378656 creator A5024911062 @default.
• W4321378656 creator A5055833791 @default.
• W4321378656 creator A5069854744 @default.
• W4321378656 creator A5091238159 @default.
• W4321378656 date "2023-03-01" @default.
• W4321378656 modified "2023-09-26" @default.
• W4321378656 title "A high level of secreted phosphoprotein 1 is associated with macrophage infiltration and poor prognosis in hepatocellular carcinoma" @default.
• W4321378656 cites W1522186213 @default.
• W4321378656 cites W1750523482 @default.
• W4321378656 cites W1825214797 @default.
• W4321378656 cites W1966107523 @default.
• W4321378656 cites W1970000032 @default.
• W4321378656 cites W1997697459 @default.
• W4321378656 cites W2014754886 @default.
• W4321378656 cites W2020285921 @default.
• W4321378656 cites W2021415784 @default.
• W4321378656 cites W2035618305 @default.
• W4321378656 cites W2078490888 @default.
• W4321378656 cites W2089142138 @default.
• W4321378656 cites W2109542348 @default.
• W4321378656 cites W2150989762 @default.
• W4321378656 cites W2159707944 @default.
• W4321378656 cites W2161689638 @default.
• W4321378656 cites W2162664959 @default.
• W4321378656 cites W2163039634 @default.
• W4321378656 cites W2179438025 @default.
• W4321378656 cites W2410126588 @default.
• W4321378656 cites W2418304545 @default.
• W4321378656 cites W2560499218 @default.
• W4321378656 cites W2597436923 @default.
• W4321378656 cites W2607211817 @default.
• W4321378656 cites W2613284188 @default.
• W4321378656 cites W2615399205 @default.
• W4321378656 cites W2738639820 @default.
• W4321378656 cites W2745901392 @default.
• W4321378656 cites W2888588041 @default.
• W4321378656 cites W2890247220 @default.
• W4321378656 cites W2896996016 @default.
• W4321378656 cites W2898701133 @default.
• W4321378656 cites W2965334126 @default.
• W4321378656 cites W2975405931 @default.
• W4321378656 cites W3016711957 @default.
• W4321378656 cites W3038095373 @default.
• W4321378656 cites W3081816381 @default.
• W4321378656 cites W3179575040 @default.
• W4321378656 doi "https://doi.org/10.1016/j.iliver.2023.01.004" @default.
• W4321378656 hasPublicationYear "2023" @default.
• W4321378656 type Work @default.
• W4321378656 citedByCount "0" @default.
• W4321378656 crossrefType "journal-article" @default.
• W4321378656 hasAuthorship W4321378656A5003591674 @default.
• W4321378656 hasAuthorship W4321378656A5018892767 @default.
• W4321378656 hasAuthorship W4321378656A5024911062 @default.
• W4321378656 hasAuthorship W4321378656A5055833791 @default.
• W4321378656 hasAuthorship W4321378656A5069854744 @default.
• W4321378656 hasAuthorship W4321378656A5091238159 @default.
• W4321378656 hasBestOaLocation W43213786561 @default.
• W4321378656 hasConcept C104317684 @default.
• W4321378656 hasConcept C10515644 @default.
• W4321378656 hasConcept C126322002 @default.
• W4321378656 hasConcept C143998085 @default.
• W4321378656 hasConcept C150194340 @default.
• W4321378656 hasConcept C190727270 @default.
• W4321378656 hasConcept C2776231280 @default.
• W4321378656 hasConcept C2777546739 @default.
• W4321378656 hasConcept C2778019345 @default.
• W4321378656 hasConcept C502942594 @default.
• W4321378656 hasConcept C54355233 @default.
• W4321378656 hasConcept C71924100 @default.
• W4321378656 hasConcept C86803240 @default.
• W4321378656 hasConceptScore W4321378656C104317684 @default.
• W4321378656 hasConceptScore W4321378656C10515644 @default.
• W4321378656 hasConceptScore W4321378656C126322002 @default.
• W4321378656 hasConceptScore W4321378656C143998085 @default.
• W4321378656 hasConceptScore W4321378656C150194340 @default.
• W4321378656 hasConceptScore W4321378656C190727270 @default.
• W4321378656 hasConceptScore W4321378656C2776231280 @default.
• W4321378656 hasConceptScore W4321378656C2777546739 @default.
• W4321378656 hasConceptScore W4321378656C2778019345 @default.
• W4321378656 hasConceptScore W4321378656C502942594 @default.
• W4321378656 hasConceptScore W4321378656C54355233 @default.
• W4321378656 hasConceptScore W4321378656C71924100 @default.
• W4321378656 hasConceptScore W4321378656C86803240 @default.
• W4321378656 hasIssue "1" @default.
• W4321378656 hasLocation W43213786561 @default.
• W4321378656 hasOpenAccess W4321378656 @default.
• W4321378656 hasPrimaryLocation W43213786561 @default.
• W4321378656 hasRelatedWork W1992278374 @default.
• W4321378656 hasRelatedWork W2009966535 @default.
• W4321378656 hasRelatedWork W2020483997 @default.
• W4321378656 hasRelatedWork W2171277769 @default.
• W4321378656 hasRelatedWork W2339150075 @default.
• W4321378656 hasRelatedWork W2375791075 @default.
• W4321378656 hasRelatedWork W2766588635 @default.

• next