FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321381453> ?p ?o ?g. }

• W4321381453 endingPage "114660" @default.
• W4321381453 startingPage "114660" @default.
• W4321381453 abstract "After intensive research on the gut-brain axis, intestinal dysbiosis is considered to be one of the important pathways of cognitive decline. Microbiota transplantation has long been thought to reverse the behavioral changes in the brain caused by colony dysregulation, but in our study, microbiota transplantation seemed to improve only behavioral brain function, and there was no reasonable explanation for the high level of hippocampal neuron apoptosis that remained. Butyric acid is one of the short-chain fatty acids of intestinal metabolites and is mainly used as an edible flavoring. It is commonly used in butter, cheese and fruit flavorings, and is a natural product of bacterial fermentation of dietary fiber and resistant starch in the colon, acting similarly to the small-molecule HDAC inhibitor TSA. The effect of butyric acid on HDAC levels in hippocampal neurons in the brain remains unclear. Therefore, this study used rats with low bacterial abundance, conditional knockout mice, microbiota transplantation, 16S rDNA amplicon sequencing, and behavioral assays to demonstrate the regulatory mechanism of short-chain fatty acids on the acetylation of hippocampal histones. The results showed that disturbance of short-chain fatty acid metabolism led to high HDAC4 expression in the hippocampus and regulated H4K8ac, H4K12ac, and H4K16ac to promote increased neuronal apoptosis. However, microbiota transplantation did not change the pattern of low butyric acid expression, resulting in maintained high HDAC4 expression in hippocampal neurons with continued neuronal apoptosis. Overall, our study shows that low levels of butyric acid in vivo can promote HDAC4 expression through the gut-brain axis pathway, leading to hippocampal neuronal apoptosis, and demonstrates that butyric acid has great potential value for neuroprotection in the brain. In this regard, we suggest that patients with chronic dysbiosis should pay attention to changes in the levels of SCFAs in their bodies, and if deficiencies occur, they should be promptly supplemented through diet and other means to avoid affecting brain health." @default.
• W4321381453 created "2023-02-21" @default.
• W4321381453 creator A5019477626 @default.
• W4321381453 creator A5025751238 @default.
• W4321381453 creator A5028706568 @default.
• W4321381453 creator A5029154538 @default.
• W4321381453 creator A5035520440 @default.
• W4321381453 creator A5047748072 @default.
• W4321381453 creator A5050875928 @default.
• W4321381453 creator A5065034761 @default.
• W4321381453 creator A5077270918 @default.
• W4321381453 creator A5082665175 @default.
• W4321381453 creator A5091282000 @default.
• W4321381453 date "2023-03-01" @default.
• W4321381453 modified "2023-10-15" @default.
• W4321381453 title "Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons" @default.
• W4321381453 cites W1995620318 @default.
• W4321381453 cites W2063666894 @default.
• W4321381453 cites W2109127169 @default.
• W4321381453 cites W2114102190 @default.
• W4321381453 cites W2115908082 @default.
• W4321381453 cites W2346063139 @default.
• W4321381453 cites W2611957242 @default.
• W4321381453 cites W2751934992 @default.
• W4321381453 cites W2800147688 @default.
• W4321381453 cites W2808778563 @default.
• W4321381453 cites W2897815582 @default.
• W4321381453 cites W2901497217 @default.
• W4321381453 cites W2902663240 @default.
• W4321381453 cites W2911396153 @default.
• W4321381453 cites W2964698358 @default.
• W4321381453 cites W2965398438 @default.
• W4321381453 cites W2988480199 @default.
• W4321381453 cites W2997561039 @default.
• W4321381453 cites W3010797436 @default.
• W4321381453 cites W3043858294 @default.
• W4321381453 cites W3048918321 @default.
• W4321381453 cites W3107445852 @default.
• W4321381453 cites W3127462604 @default.
• W4321381453 cites W3140938818 @default.
• W4321381453 cites W3148506744 @default.
• W4321381453 cites W3149061620 @default.
• W4321381453 cites W3198631777 @default.
• W4321381453 cites W4210538269 @default.
• W4321381453 cites W4280592536 @default.
• W4321381453 cites W4281747245 @default.
• W4321381453 cites W4283512018 @default.
• W4321381453 cites W4285818322 @default.
• W4321381453 cites W4296248806 @default.
• W4321381453 cites W4296524790 @default.
• W4321381453 cites W4303191854 @default.
• W4321381453 cites W4303423601 @default.
• W4321381453 cites W4312130065 @default.
• W4321381453 doi "https://doi.org/10.1016/j.ecoenv.2023.114660" @default.
• W4321381453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36812872" @default.
• W4321381453 hasPublicationYear "2023" @default.
• W4321381453 type Work @default.
• W4321381453 citedByCount "1" @default.
• W4321381453 countsByYear W43213814532023 @default.
• W4321381453 crossrefType "journal-article" @default.
• W4321381453 hasAuthorship W4321381453A5019477626 @default.
• W4321381453 hasAuthorship W4321381453A5025751238 @default.
• W4321381453 hasAuthorship W4321381453A5028706568 @default.
• W4321381453 hasAuthorship W4321381453A5029154538 @default.
• W4321381453 hasAuthorship W4321381453A5035520440 @default.
• W4321381453 hasAuthorship W4321381453A5047748072 @default.
• W4321381453 hasAuthorship W4321381453A5050875928 @default.
• W4321381453 hasAuthorship W4321381453A5065034761 @default.
• W4321381453 hasAuthorship W4321381453A5077270918 @default.
• W4321381453 hasAuthorship W4321381453A5082665175 @default.
• W4321381453 hasAuthorship W4321381453A5091282000 @default.
• W4321381453 hasBestOaLocation W43213814531 @default.
• W4321381453 hasConcept C100544194 @default.
• W4321381453 hasConcept C126322002 @default.
• W4321381453 hasConcept C134018914 @default.
• W4321381453 hasConcept C148762608 @default.
• W4321381453 hasConcept C2776229602 @default.
• W4321381453 hasConcept C2776979534 @default.
• W4321381453 hasConcept C2777165150 @default.
• W4321381453 hasConcept C2779843069 @default.
• W4321381453 hasConcept C2781161787 @default.
• W4321381453 hasConcept C2911091166 @default.
• W4321381453 hasConcept C539455810 @default.
• W4321381453 hasConcept C55493867 @default.
• W4321381453 hasConcept C71924100 @default.
• W4321381453 hasConcept C86803240 @default.
• W4321381453 hasConcept C95444343 @default.
• W4321381453 hasConceptScore W4321381453C100544194 @default.
• W4321381453 hasConceptScore W4321381453C126322002 @default.
• W4321381453 hasConceptScore W4321381453C134018914 @default.
• W4321381453 hasConceptScore W4321381453C148762608 @default.
• W4321381453 hasConceptScore W4321381453C2776229602 @default.
• W4321381453 hasConceptScore W4321381453C2776979534 @default.
• W4321381453 hasConceptScore W4321381453C2777165150 @default.
• W4321381453 hasConceptScore W4321381453C2779843069 @default.
• W4321381453 hasConceptScore W4321381453C2781161787 @default.
• W4321381453 hasConceptScore W4321381453C2911091166 @default.
• W4321381453 hasConceptScore W4321381453C539455810 @default.

• next