Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321429493> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4321429493 endingPage "1337" @default.
- W4321429493 startingPage "1328" @default.
- W4321429493 abstract "Maintaining the proper balance between excitation and inhibition is necessary to prevent cortical circuits from either falling silent or generating epileptiform activity. One mechanism through which cortical networks maintain this balance is through the activity-dependent regulation of inhibition, but whether this is achieved primarily through changes in synapse number or synaptic strength is not clear. Previously, we found that 2 d of activity deprivation increased the amplitude of miniature EPSCs (mEPSCs) onto cultured visual cortical pyramidal neurons. Here we find that this same manipulation decreases the amplitude of mIPSCs. This occurs with no change in single-channel conductance but is accompanied by a reduction in the average number of channels open during the mIPSC peak and a reduction in the intensity of staining for GABA<sub>A</sub> receptors (GABA<sub>A</sub>Rs) at postsynaptic sites. In addition, the number of synaptic sites that express detectable levels of GABA<sub>A</sub>Rs was decreased by ∼50% after activity blockade, although there was no reduction in the total number of presynaptic contacts. These data suggest that activity deprivation reduces cortical inhibition by reducing both the number of GABA<sub>A</sub>Rs clustered at synaptic sites and the number of functional inhibitory synapses. Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity." @default.
- W4321429493 created "2023-02-22" @default.
- W4321429493 creator A5063639195 @default.
- W4321429493 creator A5067229849 @default.
- W4321429493 creator A5075223907 @default.
- W4321429493 date "2002-02-15" @default.
- W4321429493 modified "2023-10-17" @default.
- W4321429493 title "Activity Deprivation Reduces Miniature IPSC Amplitude by Decreasing the Number of Postsynaptic GABA<sub>A</sub>Receptors Clustered at Neocortical Synapses" @default.
- W4321429493 doi "https://doi.org/10.1523/jneurosci.22-04-01328.2002" @default.
- W4321429493 hasPublicationYear "2002" @default.
- W4321429493 type Work @default.
- W4321429493 citedByCount "284" @default.
- W4321429493 countsByYear W43214294932012 @default.
- W4321429493 countsByYear W43214294932013 @default.
- W4321429493 countsByYear W43214294932014 @default.
- W4321429493 countsByYear W43214294932015 @default.
- W4321429493 countsByYear W43214294932016 @default.
- W4321429493 countsByYear W43214294932017 @default.
- W4321429493 countsByYear W43214294932018 @default.
- W4321429493 countsByYear W43214294932019 @default.
- W4321429493 countsByYear W43214294932020 @default.
- W4321429493 countsByYear W43214294932021 @default.
- W4321429493 countsByYear W43214294932022 @default.
- W4321429493 countsByYear W43214294932023 @default.
- W4321429493 crossrefType "journal-article" @default.
- W4321429493 hasAuthorship W4321429493A5063639195 @default.
- W4321429493 hasAuthorship W4321429493A5067229849 @default.
- W4321429493 hasAuthorship W4321429493A5075223907 @default.
- W4321429493 hasBestOaLocation W43214294931 @default.
- W4321429493 hasConcept C112592302 @default.
- W4321429493 hasConcept C12554922 @default.
- W4321429493 hasConcept C127445978 @default.
- W4321429493 hasConcept C168258287 @default.
- W4321429493 hasConcept C169760540 @default.
- W4321429493 hasConcept C170493617 @default.
- W4321429493 hasConcept C17077164 @default.
- W4321429493 hasConcept C185592680 @default.
- W4321429493 hasConcept C197341189 @default.
- W4321429493 hasConcept C200170125 @default.
- W4321429493 hasConcept C2777222312 @default.
- W4321429493 hasConcept C2910581834 @default.
- W4321429493 hasConcept C55493867 @default.
- W4321429493 hasConcept C86803240 @default.
- W4321429493 hasConceptScore W4321429493C112592302 @default.
- W4321429493 hasConceptScore W4321429493C12554922 @default.
- W4321429493 hasConceptScore W4321429493C127445978 @default.
- W4321429493 hasConceptScore W4321429493C168258287 @default.
- W4321429493 hasConceptScore W4321429493C169760540 @default.
- W4321429493 hasConceptScore W4321429493C170493617 @default.
- W4321429493 hasConceptScore W4321429493C17077164 @default.
- W4321429493 hasConceptScore W4321429493C185592680 @default.
- W4321429493 hasConceptScore W4321429493C197341189 @default.
- W4321429493 hasConceptScore W4321429493C200170125 @default.
- W4321429493 hasConceptScore W4321429493C2777222312 @default.
- W4321429493 hasConceptScore W4321429493C2910581834 @default.
- W4321429493 hasConceptScore W4321429493C55493867 @default.
- W4321429493 hasConceptScore W4321429493C86803240 @default.
- W4321429493 hasIssue "4" @default.
- W4321429493 hasLocation W43214294931 @default.
- W4321429493 hasLocation W43214294932 @default.
- W4321429493 hasLocation W43214294933 @default.
- W4321429493 hasLocation W43214294934 @default.
- W4321429493 hasOpenAccess W4321429493 @default.
- W4321429493 hasPrimaryLocation W43214294931 @default.
- W4321429493 hasRelatedWork W1546859207 @default.
- W4321429493 hasRelatedWork W1560145588 @default.
- W4321429493 hasRelatedWork W2037096045 @default.
- W4321429493 hasRelatedWork W2039958681 @default.
- W4321429493 hasRelatedWork W2069778069 @default.
- W4321429493 hasRelatedWork W2128819852 @default.
- W4321429493 hasRelatedWork W2137331977 @default.
- W4321429493 hasRelatedWork W2166043253 @default.
- W4321429493 hasRelatedWork W2513493113 @default.
- W4321429493 hasRelatedWork W4321429493 @default.
- W4321429493 hasVolume "22" @default.
- W4321429493 isParatext "false" @default.
- W4321429493 isRetracted "false" @default.
- W4321429493 workType "article" @default.