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- W4321438264 endingPage "110414" @default.
- W4321438264 startingPage "110414" @default.
- W4321438264 abstract "The anthracycline, Epirubicin (EPI), in managing breast cancer, is highly cytotoxic. Tryptophan-derived 3-indolepropionic acid (3-IPA) decreases oxidative damage, and its prospect of alleviating EPI-induced cytotoxicity was examined in rats' hypothalamus-ovary-uterus axis. Female rats: Control, EPI (2.5 mg/kg), 3-IPA alone (40 mg/kg), EPI+3-IPA (2.5 mg/kg + 20 mg/kg), EPI + 3-IPA2 (2.5 mg/kg + 40 mg/kg) were treated for 28 days. Subsequently, reproductive hormones, oxidative and inflammatory stress biomarkers, and tissue histology were examined. 3-IPA prevented EPI-induced decreases in the follicle-stimulating hormone, estradiol, progesterone and prolactin levels. EPI-mediated reduction in antioxidant enzymes, reduced glutathione and total sulfhydryl groups were partially counteracted by 3-IPA co-treatment. Increased oxidative and inflammatory stress biomarkers caused by treatment with EPI alone were lessened by 3-IPA co-treatment. Also, 3-IPA reduced histological damage in the examined tissues. Conclusively, 3-IPA ameliorated biochemical markers and tissue injury caused by EPI treatment alone via an antioxidative and anti-inflammatory mechanism while stabilising serum hormone dynamics." @default.
- W4321438264 created "2023-02-22" @default.
- W4321438264 creator A5010729706 @default.
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- W4321438264 date "2023-04-01" @default.
- W4321438264 modified "2023-09-23" @default.
- W4321438264 title "Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation" @default.
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- W4321438264 doi "https://doi.org/10.1016/j.cbi.2023.110414" @default.
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