Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321443953> ?p ?o ?g. }
- W4321443953 abstract "The 1,5-benzothiazepane structure is an important heterocyclic moiety present in a variety of commercial drugs and pharmaceuticals. This privileged scaffold exhibits a diversity of biological activities, including antimicrobial, antibacterial, anti-epileptic, anti-HIV, antidepressant, antithrombotic and anticancer properties. Its important pharmacological potential renders research into the development of new and efficient synthetic methods of high relevance. In the first part of this review, an overview of different synthetic approaches toward 1,5-benzothiazepane and its derivatives is provided, ranging from established protocols to recent (enantioselective) methods that promote sustainability. In the second part, several structural characteristics influencing biological activity are briefly explored, providing a few insights into the structure-activity relationships of these compounds." @default.
- W4321443953 created "2023-02-22" @default.
- W4321443953 creator A5012063264 @default.
- W4321443953 creator A5014142708 @default.
- W4321443953 creator A5037957827 @default.
- W4321443953 creator A5039170902 @default.
- W4321443953 date "2023-02-01" @default.
- W4321443953 modified "2023-10-01" @default.
- W4321443953 title "Synthesis of the 1,5‐Benzothiazepane Scaffold – Established Methods and New Developments" @default.
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- W4321443953 doi "https://doi.org/10.1002/open.202200262" @default.
- W4321443953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36807726" @default.
- W4321443953 hasPublicationYear "2023" @default.