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• W4321445906 abstract "Abstract Non-invasive brain stimulation has been suggested as a potential treatment for improving symptomology and cognitive deficits in Attention-Deficit/Hyperactivity Disorder (ADHD), the most common childhood neurodevelopmental disorder. Here, we examined whether a novel form of stimulation, high-frequency transcranial random noise stimulation (tRNS), applied with cognitive training (CT), may impact symptoms and neural oscillations in children with ADHD. W e conducted a randomized, double-blind sham-controlled trial in 23 unmedicated children with ADHD, who received either tRNS over the right inferior frontal gyrus (rIFG) and left dorsolateral prefrontal cortex (lDLPFC) or sham stimulation for 2 weeks, combined with CT. tRNS + CT yielded significant clinical improvements (reduced ADHD rating-scale scores) following treatment, compared to the control intervention. These improvements were maintained at a 3-week follow-up. Moreover, resting state (RS)-EEG periodic beta bandwidth of the extracted peaks was reduced in the experimental compared to control group immediately following treatment, with further reduction at follow-up. A marginally lower aperiodic exponent which reflects a higher excitation/inhibition was seen in the experimental compared to control group. The experimental group further exhibited longer sleep onset latencies and more wake-up times following treatment compared to the control group. No significant group differences were seen in executive functions, nor in reported adverse events. We conclude that tRNS + CT has a lasting clinical effect on ADHD symptoms and on beta activity. These results provide a promising direction towards a novel intervention in paediatric ADHD that induces sustained effects." @default.
• W4321445906 created "2023-02-22" @default.
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• W4321445906 date "2023-02-21" @default.
• W4321445906 modified "2023-10-16" @default.
• W4321445906 title "Transcranial Random Noise Stimulation combined with Cognitive Training for Treating ADHD: A Randomized, Sham-Controlled Clinical Trial" @default.
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• W4321445906 doi "https://doi.org/10.21203/rs.3.rs-2550466/v1" @default.
• W4321445906 hasPublicationYear "2023" @default.
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