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- W4321446839 abstract "Summary Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa ( Pa ) is of special concern since colonizing strains frequently acquire multiple drug resistance (MDR). Bactericidal/permeability-increasing protein (BPI) is a neutrophil-derived, endogenous protein with high bactericidal potency against Gram-negative bacteria. However, a significant range of CF patients produce anti-neutrophil cytoplasmic antibodies against BPI (BPI-ANCA) thereby neutralizing its bactericidal function. In accordance with literature, we describe that 54.3% of a total of 46 CF patients expressed BPI-ANCA. Importantly, an orthologous protein to human BPI (huBPI) derived from the scorpionfish Sebastes schlegelii (scoBPI) completely escaped recognition by these autoantibodies. Moreover, scoBPI exhibited high anti-inflammatory potency towards Pa LPS, and was bactericidal against MDR Pa derived from CF patients at nanomolar concentrations. In conclusion, our results highlight the potential of highly active orthologous proteins of huBPI in treatment of MDR Pa infections, especially in the presence of BPI-ANCA." @default.
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- W4321446839 date "2023-02-21" @default.
- W4321446839 modified "2023-10-03" @default.
- W4321446839 title "Scorpionfish BPI is highly active against multiple drug-resistant<i>Pseudomonas aeruginosa</i>isolates from cystic fibrosis patients" @default.
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- W4321446839 doi "https://doi.org/10.1101/2023.02.19.529133" @default.
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