FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321452211> ?p ?o ?g. }

• W4321452211 abstract "Hepatocellular carcinoma (HCC) is associated with a high occurrence, mortality, and poor prognosis. MLX interacting protein like (MLXIPL) is an important regulator of glucolipid metabolism and is involved in tumor progression. We aimed to clarify the role of MLXIPL in HCC and its underlying mechanisms.The level of MLXIPL was predicted using bioinformatic analysis and verified using quantitative real-time PCR (qPCR), immunohistochemical analysis, and western blot. We assessed the effects of MLXIPL on biological behaviors using the cell counting kit-8, colony formation, and Transwell assay. Glycolysis was evaluated using the Seahorse method. The interaction between MLXIPL and mechanistic target of rapamycin kinase (mTOR) was confirmed using RNA immunoprecipitation and co-immunoprecipitation. mTOR expression was detected in HCC cells using qPCR, immunofluorescence analysis, and western blot.The results showed that MLXIPL levels were elevated in both HCC tissues and HCC cell lines. Knockdown of MLXIPL impeded HCC cell growth, invasion, migration, and glycolysis. Moreover, MLXIPL combined with mTOR to induce phosphorylation of mTOR. Activated mTOR abrogated the effects on cellular processes induced by MLXIPL.MLXIPL promoted the malignant progression of HCC by activating phosphorylation of mTOR, suggesting an important role of the combination of MLXIPL and mTOR in HCC." @default.
• W4321452211 created "2023-02-22" @default.
• W4321452211 creator A5009116182 @default.
• W4321452211 creator A5034026217 @default.
• W4321452211 creator A5046736908 @default.
• W4321452211 creator A5048885442 @default.
• W4321452211 creator A5068853170 @default.
• W4321452211 date "2023-02-21" @default.
• W4321452211 modified "2023-09-26" @default.
• W4321452211 title "MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR" @default.
• W4321452211 cites W1748636648 @default.
• W4321452211 cites W1927484032 @default.
• W4321452211 cites W1967701592 @default.
• W4321452211 cites W2118107482 @default.
• W4321452211 cites W2129824771 @default.
• W4321452211 cites W2137794530 @default.
• W4321452211 cites W2137960344 @default.
• W4321452211 cites W2331437175 @default.
• W4321452211 cites W2339236494 @default.
• W4321452211 cites W2557813572 @default.
• W4321452211 cites W2598984757 @default.
• W4321452211 cites W2625225193 @default.
• W4321452211 cites W2741150613 @default.
• W4321452211 cites W2800244877 @default.
• W4321452211 cites W2945856748 @default.
• W4321452211 cites W2954917865 @default.
• W4321452211 cites W2968179661 @default.
• W4321452211 cites W2969086321 @default.
• W4321452211 cites W2992913894 @default.
• W4321452211 cites W3009604911 @default.
• W4321452211 cites W3016248999 @default.
• W4321452211 cites W3038789517 @default.
• W4321452211 cites W3086727613 @default.
• W4321452211 cites W3097087197 @default.
• W4321452211 cites W3114011899 @default.
• W4321452211 cites W3122989566 @default.
• W4321452211 cites W3141013921 @default.
• W4321452211 cites W3198087373 @default.
• W4321452211 cites W3203200636 @default.
• W4321452211 cites W4238567307 @default.
• W4321452211 doi "https://doi.org/10.1186/s12885-023-10652-5" @default.
• W4321452211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36809979" @default.
• W4321452211 hasPublicationYear "2023" @default.
• W4321452211 type Work @default.
• W4321452211 citedByCount "0" @default.
• W4321452211 crossrefType "journal-article" @default.
• W4321452211 hasAuthorship W4321452211A5009116182 @default.
• W4321452211 hasAuthorship W4321452211A5034026217 @default.
• W4321452211 hasAuthorship W4321452211A5046736908 @default.
• W4321452211 hasAuthorship W4321452211A5048885442 @default.
• W4321452211 hasAuthorship W4321452211A5068853170 @default.
• W4321452211 hasBestOaLocation W43214522111 @default.
• W4321452211 hasConcept C104317684 @default.
• W4321452211 hasConcept C11960822 @default.
• W4321452211 hasConcept C134018914 @default.
• W4321452211 hasConcept C173396325 @default.
• W4321452211 hasConcept C20251656 @default.
• W4321452211 hasConcept C2776415932 @default.
• W4321452211 hasConcept C2778019345 @default.
• W4321452211 hasConcept C502942594 @default.
• W4321452211 hasConcept C54355233 @default.
• W4321452211 hasConcept C55493867 @default.
• W4321452211 hasConcept C62112901 @default.
• W4321452211 hasConcept C62231903 @default.
• W4321452211 hasConcept C62478195 @default.
• W4321452211 hasConcept C71829478 @default.
• W4321452211 hasConcept C81885089 @default.
• W4321452211 hasConcept C85265743 @default.
• W4321452211 hasConcept C86554907 @default.
• W4321452211 hasConcept C86803240 @default.
• W4321452211 hasConcept C95444343 @default.
• W4321452211 hasConceptScore W4321452211C104317684 @default.
• W4321452211 hasConceptScore W4321452211C11960822 @default.
• W4321452211 hasConceptScore W4321452211C134018914 @default.
• W4321452211 hasConceptScore W4321452211C173396325 @default.
• W4321452211 hasConceptScore W4321452211C20251656 @default.
• W4321452211 hasConceptScore W4321452211C2776415932 @default.
• W4321452211 hasConceptScore W4321452211C2778019345 @default.
• W4321452211 hasConceptScore W4321452211C502942594 @default.
• W4321452211 hasConceptScore W4321452211C54355233 @default.
• W4321452211 hasConceptScore W4321452211C55493867 @default.
• W4321452211 hasConceptScore W4321452211C62112901 @default.
• W4321452211 hasConceptScore W4321452211C62231903 @default.
• W4321452211 hasConceptScore W4321452211C62478195 @default.
• W4321452211 hasConceptScore W4321452211C71829478 @default.
• W4321452211 hasConceptScore W4321452211C81885089 @default.
• W4321452211 hasConceptScore W4321452211C85265743 @default.
• W4321452211 hasConceptScore W4321452211C86554907 @default.
• W4321452211 hasConceptScore W4321452211C86803240 @default.
• W4321452211 hasConceptScore W4321452211C95444343 @default.
• W4321452211 hasIssue "1" @default.
• W4321452211 hasLocation W43214522111 @default.
• W4321452211 hasLocation W43214522112 @default.
• W4321452211 hasLocation W43214522113 @default.
• W4321452211 hasOpenAccess W4321452211 @default.
• W4321452211 hasPrimaryLocation W43214522111 @default.
• W4321452211 hasRelatedWork W2185708255 @default.
• W4321452211 hasRelatedWork W2384299429 @default.
• W4321452211 hasRelatedWork W3024065858 @default.
• W4321452211 hasRelatedWork W3103486612 @default.

• next