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- W4321453513 abstract "Bacterial populations communicate using quorum-sensing (QS) molecules and switch on QS regulation to engage in coordinated behaviour such as biofilm formation or virulence. The marine fish pathogen Vibrio anguillarum harbours several QS systems, and our understanding of its QS regulation is still fragmentary. Here, we identify the VanT-QS regulon and explore the diversity and trajectory of traits under QS regulation in Vibrio anguillarum through comparative transcriptomics of two wildtype strains and their corresponding mutants artificially locked in QS-on (ΔvanO) or QS-off (ΔvanT) states. Intriguingly, the two wildtype populations showed different QS responses to cell density changes and operated primarily in the QS-on and QS-off spectrum, respectively. Examining 27 V. anguillarum strains revealed that ~11% were QS-negative, and GFP-reporter measurements of nine QS-positive strains revealed a highly strain-specific nature of the QS responses. We showed that QS controls a plethora of genes involved in processes such as central metabolism, biofilm formation, competence, T6SS, and virulence properties in V. anguillarum, with large strain-specific differences. Moreover, we demonstrated that the QS state is an important driver of virulence towards fish larvae in one of two V. anguillarum strains. We speculate that infections by mixed-strain communities spanning diverse QS strategies optimize the infection efficiency of the pathogen." @default.
- W4321453513 created "2023-02-22" @default.
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- W4321453513 date "2023-03-16" @default.
- W4321453513 modified "2023-10-01" @default.
- W4321453513 title "Strain‐specific quorum‐sensing responses determine virulence properties in <scp><i>Vibrio anguillarum</i></scp>" @default.
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- W4321453513 cites W1968498709 @default.
- W4321453513 cites W1972407743 @default.
- W4321453513 cites W1974199694 @default.
- W4321453513 cites W1979152503 @default.
- W4321453513 cites W1991330646 @default.
- W4321453513 cites W1992841053 @default.
- W4321453513 cites W1993381520 @default.
- W4321453513 cites W1996872292 @default.
- W4321453513 cites W1998745754 @default.
- W4321453513 cites W2000106451 @default.
- W4321453513 cites W2002350992 @default.
- W4321453513 cites W2016402044 @default.
- W4321453513 cites W2043015302 @default.
- W4321453513 cites W2051249607 @default.
- W4321453513 cites W2060095084 @default.
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- W4321453513 cites W2061911708 @default.
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- W4321453513 cites W2114104545 @default.
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- W4321453513 cites W2129254217 @default.
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- W4321453513 cites W2134440848 @default.
- W4321453513 cites W2135185121 @default.
- W4321453513 cites W2136294927 @default.
- W4321453513 cites W2136918853 @default.
- W4321453513 cites W2137526110 @default.
- W4321453513 cites W2138207763 @default.
- W4321453513 cites W2138432201 @default.
- W4321453513 cites W2144533615 @default.
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- W4321453513 cites W2153793431 @default.
- W4321453513 cites W2154598603 @default.
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- W4321453513 cites W2167970476 @default.
- W4321453513 cites W2169400224 @default.
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- W4321453513 cites W2599925393 @default.
- W4321453513 cites W2611999515 @default.
- W4321453513 cites W2799828084 @default.
- W4321453513 cites W2806983452 @default.
- W4321453513 cites W2885656168 @default.
- W4321453513 cites W2890464968 @default.
- W4321453513 cites W2911420836 @default.
- W4321453513 cites W2948257641 @default.
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- W4321453513 doi "https://doi.org/10.1111/1462-2920.16356" @default.
- W4321453513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36807464" @default.
- W4321453513 hasPublicationYear "2023" @default.
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