Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321457518> ?p ?o ?g. }
- W4321457518 abstract "Abstract Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor progression, recurrence and chemoresistance due to their typical stemness characteristics. CSCs are preferentially distributed in niches, and those niche sites exhibit characteristics typical of the tumor microenvironment (TME). The complex interactions between CSCs and TME illustrate these synergistic effects. The phenotypic heterogeneity within CSCs and the spatial interactions with the surrounding tumor microenvironment led to increased therapeutic challenges. CSCs interact with immune cells to protect themselves against immune clearance by exploiting the immunosuppressive function of multiple immune checkpoint molecules. CSCs also can protect themselves against immune surveillance by excreting extracellular vesicles (EVs), growth factors, metabolites and cytokines into the TME, thereby modulating the composition of the TME. Therefore, these interactions are also being considered for the therapeutic development of anti-tumor agents. We discuss here the immune molecular mechanisms of CSCs and comprehensively review the interplay between CSCs and the immune system. Thus, studies on this topic seem to provide novel ideas for reinvigorating therapeutic approaches to cancer." @default.
- W4321457518 created "2023-02-22" @default.
- W4321457518 creator A5004330694 @default.
- W4321457518 creator A5069219056 @default.
- W4321457518 creator A5084201050 @default.
- W4321457518 creator A5087805205 @default.
- W4321457518 date "2023-02-21" @default.
- W4321457518 modified "2023-10-15" @default.
- W4321457518 title "Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment" @default.
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