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• W4321460787 endingPage "104291" @default.
• W4321460787 startingPage "104291" @default.
• W4321460787 abstract "Using chitosan (CS) as a mucoadhesive as well as pH-sensitive polymer, a chemically crosslinked novel CS/PVP-co-poly (AMPS) network-based hydrogels was fabricated by utilizing a radical polymerization approach followed by successful loading of captopril by applying the diffusion-aided-swelling technique. The physicochemical properties like the conformation of chemical groups, as well as physical entrapment of captopril into hydrogel network with a slight shifting of peaks illustrated by FTIR. Porous surface morphology of hydrogel aids in the uniformed entrapment of captopril molecules within matrix was demonstrated by SEM. The diminished captopril sharp peaks at 2θ = 10.91°, 17.09°, and 18.95° in the PXRD spectra of loaded hydrogel showed that drug molecules were dispersed at the molecular level and conversion of crystalline nature drug and polymer into amorphous hydrogel system which in turned aid in the dissolution profile. TGA as well as DSC illustrated the thermally stable fabricated hydrogels deterioration at a higher temperature which ensured the compact integrity of matrix. Dissolution ensured that the developed hydrogel system was inflated more and released up to 95.74% captopril at 1.2 pH. The presence of higher chitosan concentration in formulation CPAE-3 has more mucoadhesion potential (144 min) than others which confirmed that chitosan was responsible for the mucoadhesive properties. In-vivo toxicity studies proved that designed hydrogel systems were nontoxic and biocompatible. According to the results, the novel mucoadhesive, pH-sensitive, CS/PVP-co-poly (AMPS) network-based hydrogels were successfully developed for captopril to maximize the drug absorption at the stomach to achieve better bioavailability and sustained released pattern." @default.
• W4321460787 created "2023-02-22" @default.
• W4321460787 creator A5027907363 @default.
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• W4321460787 date "2023-03-01" @default.
• W4321460787 modified "2023-10-14" @default.
• W4321460787 title "Mucoadhesive chitosan/polyvinylpyrrolidone-co-poly (2-acrylamide-2-methylpropane sulphonic acid) based hydrogels of captopril with adjustable properties as sustained release carrier: Formulation design and toxicological evaluation" @default.
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• W4321460787 doi "https://doi.org/10.1016/j.jddst.2023.104291" @default.
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