Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321481231> ?p ?o ?g. }
- W4321481231 endingPage "e1010514" @default.
- W4321481231 startingPage "e1010514" @default.
- W4321481231 abstract "Structural variations (SVs) are a key type of cancer genomic alterations, contributing to oncogenesis and progression of many cancers, including colorectal cancer (CRC). However, SVs in CRC remain difficult to be reliably detected due to limited SV-detection capacity of the commonly used short-read sequencing. This study investigated the somatic SVs in 21 pairs of CRC samples by Nanopore whole-genome long-read sequencing. 5200 novel somatic SVs from 21 CRC patients (494 SVs / patient) were identified. A 4.9-Mbp long inversion that silences APC expression (confirmed by RNA-seq) and an 11.2-kbp inversion that structurally alters CFTR were identified. Two novel gene fusions that might functionally impact the oncogene RNF38 and the tumor-suppressor SMAD3 were detected. RNF38 fusion possesses metastasis-promoting ability confirmed by in vitro migration and invasion assay, and in vivo metastasis experiments. This work highlighted the various applications of long-read sequencing in cancer genome analysis, and shed new light on how somatic SVs structurally alter critical genes in CRC. The investigation on somatic SVs via nanopore sequencing revealed the potential of this genomic approach in facilitating precise diagnosis and personalized treatment of CRC." @default.
- W4321481231 created "2023-02-23" @default.
- W4321481231 creator A5022591242 @default.
- W4321481231 creator A5023495158 @default.
- W4321481231 creator A5029554405 @default.
- W4321481231 creator A5037976593 @default.
- W4321481231 creator A5042675351 @default.
- W4321481231 creator A5045395711 @default.
- W4321481231 creator A5053275663 @default.
- W4321481231 creator A5068712509 @default.
- W4321481231 creator A5072886386 @default.
- W4321481231 creator A5080032910 @default.
- W4321481231 date "2023-02-22" @default.
- W4321481231 modified "2023-10-10" @default.
- W4321481231 title "Long-read sequencing identifies novel structural variations in colorectal cancer" @default.
- W4321481231 cites W1973067702 @default.
- W4321481231 cites W2002438422 @default.
- W4321481231 cites W2034820020 @default.
- W4321481231 cites W2045807857 @default.
- W4321481231 cites W2053333794 @default.
- W4321481231 cites W2082534286 @default.
- W4321481231 cites W2083457841 @default.
- W4321481231 cites W2084256558 @default.
- W4321481231 cites W2104056992 @default.
- W4321481231 cites W2115520939 @default.
- W4321481231 cites W2147429782 @default.
- W4321481231 cites W2157392712 @default.
- W4321481231 cites W223909586 @default.
- W4321481231 cites W2262414037 @default.
- W4321481231 cites W2464063823 @default.
- W4321481231 cites W2480324413 @default.
- W4321481231 cites W2555392689 @default.
- W4321481231 cites W2607669908 @default.
- W4321481231 cites W2623862783 @default.
- W4321481231 cites W2626923045 @default.
- W4321481231 cites W2747774814 @default.
- W4321481231 cites W2792896484 @default.
- W4321481231 cites W2811522864 @default.
- W4321481231 cites W2887198695 @default.
- W4321481231 cites W2889646458 @default.
- W4321481231 cites W2891816579 @default.
- W4321481231 cites W2891870314 @default.
- W4321481231 cites W2908721251 @default.
- W4321481231 cites W2921927823 @default.
- W4321481231 cites W2923631155 @default.
- W4321481231 cites W2923956523 @default.
- W4321481231 cites W2950121474 @default.
- W4321481231 cites W2950214184 @default.
- W4321481231 cites W2950827710 @default.
- W4321481231 cites W2951149781 @default.
- W4321481231 cites W3000228397 @default.
- W4321481231 cites W3033870872 @default.
- W4321481231 cites W3112249938 @default.
- W4321481231 cites W3213101281 @default.
- W4321481231 doi "https://doi.org/10.1371/journal.pgen.1010514" @default.
- W4321481231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36812239" @default.
- W4321481231 hasPublicationYear "2023" @default.
- W4321481231 type Work @default.
- W4321481231 citedByCount "2" @default.
- W4321481231 countsByYear W43214812312023 @default.
- W4321481231 crossrefType "journal-article" @default.
- W4321481231 hasAuthorship W4321481231A5022591242 @default.
- W4321481231 hasAuthorship W4321481231A5023495158 @default.
- W4321481231 hasAuthorship W4321481231A5029554405 @default.
- W4321481231 hasAuthorship W4321481231A5037976593 @default.
- W4321481231 hasAuthorship W4321481231A5042675351 @default.
- W4321481231 hasAuthorship W4321481231A5045395711 @default.
- W4321481231 hasAuthorship W4321481231A5053275663 @default.
- W4321481231 hasAuthorship W4321481231A5068712509 @default.
- W4321481231 hasAuthorship W4321481231A5072886386 @default.
- W4321481231 hasAuthorship W4321481231A5080032910 @default.
- W4321481231 hasBestOaLocation W43214812311 @default.
- W4321481231 hasConcept C104317684 @default.
- W4321481231 hasConcept C121608353 @default.
- W4321481231 hasConcept C126513998 @default.
- W4321481231 hasConcept C134305767 @default.
- W4321481231 hasConcept C141231307 @default.
- W4321481231 hasConcept C205270622 @default.
- W4321481231 hasConcept C24432333 @default.
- W4321481231 hasConcept C2779013556 @default.
- W4321481231 hasConcept C502942594 @default.
- W4321481231 hasConcept C526805850 @default.
- W4321481231 hasConcept C54355233 @default.
- W4321481231 hasConcept C555283112 @default.
- W4321481231 hasConcept C70721500 @default.
- W4321481231 hasConcept C86803240 @default.
- W4321481231 hasConceptScore W4321481231C104317684 @default.
- W4321481231 hasConceptScore W4321481231C121608353 @default.
- W4321481231 hasConceptScore W4321481231C126513998 @default.
- W4321481231 hasConceptScore W4321481231C134305767 @default.
- W4321481231 hasConceptScore W4321481231C141231307 @default.
- W4321481231 hasConceptScore W4321481231C205270622 @default.
- W4321481231 hasConceptScore W4321481231C24432333 @default.
- W4321481231 hasConceptScore W4321481231C2779013556 @default.
- W4321481231 hasConceptScore W4321481231C502942594 @default.
- W4321481231 hasConceptScore W4321481231C526805850 @default.
- W4321481231 hasConceptScore W4321481231C54355233 @default.
- W4321481231 hasConceptScore W4321481231C555283112 @default.