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- W4321481643 abstract "Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of ISG15+HLADRhi and CD48highS100A2pos monocytes, recently identified in inflamed RA synovia and blood of those with RA flares. The oral bacteria observed transiently in blood were broadly citrullinated in the mouth, and their in situ citrullinated epitopes were targeted by extensively somatically hypermutated ACPAs encoded by RA blood plasmablasts. Together, these results suggest that (i) periodontal disease results in repeated breaches of the oral mucosa that release citrullinated oral bacteria into circulation, which (ii) activate inflammatory monocyte subsets that are observed in inflamed RA synovia and blood of RA patients with flares and (iii) activate ACPA B cells, thereby promoting affinity maturation and epitope spreading to citrullinated human antigens." @default.
- W4321481643 created "2023-02-23" @default.
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- W4321481643 date "2023-02-22" @default.
- W4321481643 modified "2023-10-06" @default.
- W4321481643 title "Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis" @default.
- W4321481643 cites W135571511 @default.
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- W4321481643 cites W1977671332 @default.
- W4321481643 cites W1983444348 @default.
- W4321481643 cites W1994080141 @default.
- W4321481643 cites W1998890104 @default.
- W4321481643 cites W2014113929 @default.
- W4321481643 cites W2023621352 @default.
- W4321481643 cites W2024988150 @default.
- W4321481643 cites W2040866345 @default.
- W4321481643 cites W2054407804 @default.
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- W4321481643 cites W2092698930 @default.
- W4321481643 cites W2094532029 @default.
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- W4321481643 cites W2113552312 @default.
- W4321481643 cites W2114104545 @default.
- W4321481643 cites W2114783114 @default.
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- W4321481643 cites W2118185093 @default.
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- W4321481643 cites W2128952811 @default.
- W4321481643 cites W2129135821 @default.
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- W4321481643 cites W2152348310 @default.
- W4321481643 cites W2156070134 @default.
- W4321481643 cites W2169156878 @default.
- W4321481643 cites W2170551349 @default.
- W4321481643 cites W2194610686 @default.
- W4321481643 cites W2338733954 @default.
- W4321481643 cites W2401404581 @default.
- W4321481643 cites W2474407366 @default.
- W4321481643 cites W2474986571 @default.
- W4321481643 cites W2520478522 @default.
- W4321481643 cites W2528528379 @default.
- W4321481643 cites W2529394280 @default.
- W4321481643 cites W2562800512 @default.
- W4321481643 cites W2741797984 @default.
- W4321481643 cites W2749574427 @default.
- W4321481643 cites W2756958651 @default.
- W4321481643 cites W2759451658 @default.
- W4321481643 cites W2761635793 @default.
- W4321481643 cites W2787389701 @default.
- W4321481643 cites W2789843538 @default.
- W4321481643 cites W2796965506 @default.
- W4321481643 cites W2808487458 @default.
- W4321481643 cites W2808835989 @default.
- W4321481643 cites W2813305459 @default.
- W4321481643 cites W2892206041 @default.
- W4321481643 cites W2919734007 @default.
- W4321481643 cites W2944312460 @default.
- W4321481643 cites W2947189704 @default.
- W4321481643 cites W2950245396 @default.