FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4321482746> ?p ?o ?g. }

• W4321482746 endingPage "1299" @default.
• W4321482746 startingPage "1283" @default.
• W4321482746 abstract "Sepsis causes significant morbidity and mortality worldwide. Resuscitation is a cornerstone of management. This review covers five areas of evolving practice in the management of early sepsis-induced hypoperfusion: fluid resuscitation volume, timing of vasopressor initiation, resuscitation targets, route of vasopressor administration, and use of invasive blood pressure monitoring. For each topic, we review the seminal evidence, discuss the evolution of practice over time, and highlight questions for additional research. Intravenous fluids are a core component of early sepsis resuscitation. However, with growing concerns about the harms of fluid, practice is evolving toward smaller-volume resuscitation, which is often paired with earlier vasopressor initiation. Large trials of fluid-restrictive, vasopressor-early strategies are providing more information about the safety and potential benefit of these approaches. Lowering blood pressure targets is a means to prevent fluid overload and reduce exposure to vasopressors; mean arterial pressure targets of 60-65 mm Hg appear to be safe, at least in older patients. With the trend toward earlier vasopressor initiation, the need for central administration of vasopressors has been questioned, and peripheral vasopressor use is increasing, although it is not universally accepted. Similarly, although guidelines suggest the use of invasive blood pressure monitoring with arterial catheters in patients receiving vasopressors, blood pressure cuffs are less invasive and often sufficient. Overall, the management of early sepsis-induced hypoperfusion is evolving toward fluid-sparing and less-invasive strategies. However, many questions remain, and additional data are needed to further optimize our approach to resuscitation." @default.
• W4321482746 created "2023-02-23" @default.
• W4321482746 creator A5012228981 @default.
• W4321482746 creator A5013704262 @default.
• W4321482746 creator A5016346905 @default.
• W4321482746 creator A5028770634 @default.
• W4321482746 creator A5038005820 @default.
• W4321482746 creator A5062671829 @default.
• W4321482746 creator A5089353142 @default.
• W4321482746 date "2023-05-15" @default.
• W4321482746 modified "2023-10-04" @default.
• W4321482746 title "Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review" @default.
• W4321482746 cites W1839481804 @default.
• W4321482746 cites W1977495126 @default.
• W4321482746 cites W1986115587 @default.
• W4321482746 cites W2007765175 @default.
• W4321482746 cites W2031608109 @default.
• W4321482746 cites W2035705349 @default.
• W4321482746 cites W2051942363 @default.
• W4321482746 cites W2054938569 @default.
• W4321482746 cites W2057364247 @default.
• W4321482746 cites W2061149030 @default.
• W4321482746 cites W2064068821 @default.
• W4321482746 cites W2064331604 @default.
• W4321482746 cites W2074225649 @default.
• W4321482746 cites W2079775834 @default.
• W4321482746 cites W2082308875 @default.
• W4321482746 cites W2089830179 @default.
• W4321482746 cites W2092583490 @default.
• W4321482746 cites W2095421042 @default.
• W4321482746 cites W2096350581 @default.
• W4321482746 cites W2096883458 @default.
• W4321482746 cites W2097786723 @default.
• W4321482746 cites W2098019283 @default.
• W4321482746 cites W2099296845 @default.
• W4321482746 cites W2104415072 @default.
• W4321482746 cites W2106721231 @default.
• W4321482746 cites W2113961570 @default.
• W4321482746 cites W2122560363 @default.
• W4321482746 cites W2133505354 @default.
• W4321482746 cites W2136111108 @default.
• W4321482746 cites W2156125520 @default.
• W4321482746 cites W2159979844 @default.
• W4321482746 cites W2160691650 @default.
• W4321482746 cites W2165721969 @default.
• W4321482746 cites W2214145300 @default.
• W4321482746 cites W2280404143 @default.
• W4321482746 cites W2287296216 @default.
• W4321482746 cites W2295293961 @default.
• W4321482746 cites W2330688894 @default.
• W4321482746 cites W2461553457 @default.
• W4321482746 cites W2508264804 @default.
• W4321482746 cites W2511188500 @default.
• W4321482746 cites W2580396496 @default.
• W4321482746 cites W2604209262 @default.
• W4321482746 cites W2625233900 @default.
• W4321482746 cites W2707065610 @default.
• W4321482746 cites W2736983536 @default.
• W4321482746 cites W2757089737 @default.
• W4321482746 cites W2775883273 @default.
• W4321482746 cites W2801360758 @default.
• W4321482746 cites W2887867256 @default.
• W4321482746 cites W2898967013 @default.
• W4321482746 cites W2899042155 @default.
• W4321482746 cites W2899937596 @default.
• W4321482746 cites W2901165032 @default.
• W4321482746 cites W2909812503 @default.
• W4321482746 cites W2912715599 @default.
• W4321482746 cites W2912774204 @default.
• W4321482746 cites W2920955762 @default.
• W4321482746 cites W2939690307 @default.
• W4321482746 cites W2941923737 @default.
• W4321482746 cites W2945605269 @default.
• W4321482746 cites W2979776779 @default.
• W4321482746 cites W2983345337 @default.
• W4321482746 cites W2983935547 @default.
• W4321482746 cites W2985332844 @default.
• W4321482746 cites W2998853022 @default.
• W4321482746 cites W3001911146 @default.
• W4321482746 cites W300359691 @default.
• W4321482746 cites W3005570206 @default.
• W4321482746 cites W3008040894 @default.
• W4321482746 cites W3010551088 @default.
• W4321482746 cites W3016605218 @default.
• W4321482746 cites W3020551346 @default.
• W4321482746 cites W3091691625 @default.
• W4321482746 cites W3112047593 @default.
• W4321482746 cites W3121655483 @default.
• W4321482746 cites W3154792063 @default.
• W4321482746 cites W3175563387 @default.
• W4321482746 cites W3186862414 @default.
• W4321482746 cites W3194033777 @default.
• W4321482746 cites W3203103016 @default.
• W4321482746 cites W4220993476 @default.
• W4321482746 cites W4226113737 @default.
• W4321482746 cites W4281705189 @default.
• W4321482746 cites W4282923241 @default.
• W4321482746 cites W4283011822 @default.

• next